Objective,2,To study the effect of Jianpi Liqi Decoction on the improvement of micro-inflammation in duodenum of rats with functional dyspepsia（FD）.,Methods,2,24 SD male rats were randomly divided into normal group（6 rats）and model group（18 rats）.The FD rat model was established by tail-clamping stress.Then the model group was randomly divided into FD model group，Chinese herbal medicine treatment group and CRH antagonist group.The normal and model group were given pure water by intragastric administration，while the Chinese herbal medicine treatment group was given Jianpi Liqi Decoction by intragastric administration，for 7 days and the CRH antagonist was injected intraperitoneally to the antagonist group before tail-clamping stress was used at 8 o'clock every day from the 1st day of modeling till the end of modeling.After the intervention finished，the deudenum，hypothalamus，and serum of the rats in each group were taken，and HE staining was used to observe the basic structure of duedenum，and Western blotting and ELISA to measure the content of Corticotropin-Releasing Hormone（CRH）in the hypothalamus，duedenum and serum，and Western blotting to measure the content of substance P（SP），eosinophilic major basic protein（MBP），and the expression of tryptase protein in mast cells in the duodenal tissues.,Results,2,There was no obvious abnormality in the structure and morphology of duodenum，ulcer，intestinal villi destruction and obvious inflammation in each group were not seen.There was no significant difference in the CRH content in the hypothalamus of rats in each group（,P,>,0.05）.The content of CRH in duodenum and serum of model group was higher than that of normal group（,P,<,0.05）.The content of CRH in duodenum and serum in the treatment group was lower than that in the model group（,P,<,0.05）.Serum CRH content in antagonist group was lower than that in model group （,P,<,0.05），but there was no significant difference in duodenal CRH content between antagonist group and model group（,P,>,0.05）.SP content，MBP and Tryptase protein expression in duodenum of model group were higher than those of normal group（,P,<,0.05）.The SP content，MBP and Tryptase protein expression in duodenum of the treatment group were lower than those of the model group（,P,<,0.05）.The expression of Tryptase protein in duodenum of antagonist group was lower than that of model group（,P,<,0.05），and SP content and MBP protein expression were lower than those of model group，but the difference was not statistically significant（,P,>,0.05）.,Conclusion,2,Jianpi Liqi Decoction may improve local duodenal micro-inflammation in duodenum，such as eosinophils and mast cell infiltration，and have a therapeutic effect on FD by inhibiting SP-mediated activation of the brain gut axis under stress.