Thrombocytopenia is a common complication of chronic liver disease， the patients can have the coagulation mechanism damaged，causing bleeding in the skin， mucous membranes and even organs，which may affect the prognosis and become life-threatening in severe cases. Ying （nutrient blood） and Wei （defensive qi） are originated from water and food. Ying takes Qi as the nature， and Wei takes blood as the nature. When Ying and Wei is in harmony， the body will be in a constant state of balance. The pathogenesis of thrombocytopenia in liver cirrhosis is caused by the disharmony between Yin and Wei. On the one hand，the lack of harmony between Yin and Wei is due to stagnation of Wei qi and hesitant flow of Ying blood ， making blood difficult to flow along the meridians and then out of the vessles. Secondly， deficiency of Qi in the middle jiao and insufficient production of qi and blood may lead to the defect of blood quality. The syndrome differentiation and treatment should focus on grasping the key points of pathogenesis， clarifying the impassability or insufficiency， and harmonizing the middle jiao as the basic therapeutic principle.,Clinically， Guizhi Decoction and other decoctions in same category can be used and modified according to the changes of the disease in order to regulate Ying Qi and Wei blood， tonify the middle jiao， and the clinical and experimental evidence should also be considered to ensure the efficacy.It has guiding significance for the treatment of liver cirrhosis and thrombocytopenia.