Clinical observation on asthenospermia due to kidney and essence deficiency with Yishen Zhongzi Prescription

HAN Qiang; WANG Ren-yuan; WANG He-tian; JIA Lian-cheng; LI Wei-guang; ZENG Yin

doi:10.16025/j.1674-1307.2022.09.026

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Clinical observation on asthenospermia due to kidney and essence deficiency with Yishen Zhongzi Prescription

更新时间：2023-06-16

- Clinical observation on asthenospermia due to kidney and essence deficiency with Yishen Zhongzi Prescription
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 9, Pages: 1049-1052(2022)
- 作者机构：
  
  1.首都医科大学附属北京中医医院男科，北京 100010
  2.首都医科大学附属北京中医医院泌尿外科，北京 100010
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.09.026
  CLC：
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韩强，王任远，王和天，等.益肾种子方治疗肾虚精亏型弱精子症疗效观察［J］.北京中医药，2022，41（9）：1049-1052.

HAN Qiang,WANG Ren-yuan,WANG He-tian,et al.Clinical observation on asthenospermia due to kidney and essence deficiency with Yishen Zhongzi Prescription[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(09):1049-1052.
韩强，王任远，王和天，等.益肾种子方治疗肾虚精亏型弱精子症疗效观察［J］.北京中医药，2022，41（9）：1049-1052. DOI： 10.16025/j.1674-1307.2022.09.026.

HAN Qiang,WANG Ren-yuan,WANG He-tian,et al.Clinical observation on asthenospermia due to kidney and essence deficiency with Yishen Zhongzi Prescription[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(09):1049-1052. DOI： 10.16025/j.1674-1307.2022.09.026.

摘要

目的,2,观察益肾种子方治疗肾虚精亏型弱精子症的临床效果。,方法,2,将140例弱精子症患者按照随机数字表法分为2组，试验组70例，对照组70例。试验组服用益肾种子方，对照组服用维参锌胶囊，4周为1个疗程，3个疗程后观察2组临床疗效、治疗前后精子活力、精子DNA碎片率（DFI）、中医症状积分等变化。,结果,2,治疗后，试验组总有效率80.60%，高于对照组的55.38%（,P,<,0.05）；2组精子活力均较治疗前升高（,P,<,0.05），且试验组优于对照组（,P,<,0.05）；试验组治疗后DFI下降（,P,<,0.05），且低于对照组（,P,<,0.05）。治疗期间试验组2例空腹服药后出现胃胀，后改为饭后1 h服用，胃胀消失，未见其他不适；对照组3例服药后出现胃胀，患者自行停药，因此脱落。2组血、尿常规，肝、肾功能等检查均未见异常。,结论,2,益肾种子方能改善肾虚精亏型弱精子症患者精子活力、降低精子DFI，具有良好的临床疗效，且安全性较高。

Abstract

Objective,2,To investigate the effect of Yishen Zhongzi Presription on asthenospermia patients with kidney and essence deficiency.,Methods,2,140 patients with asthenospermia were randomly divided into two groups according to the random number table method，70 cases in treatment group and 70 cases in control group.The treatment group was treated with Yishen Zhongzi Prescription，and the control group was treated with Weishen Zinc Capsule.Four weeks was one course of treatment. After three courses，the clinical efficacy，sperm motility，sperm DFI，TCM symptom score and other main parameters of the two groups before and after the treatment were observed.,Results,2,After the treatment， the effective rate was 80.60% in the treatment group and 55.38% in the control group， the difference was statistically significant（,P,<,0.05）.The sperm motility of two groups after the treatment was higher than that before the treatment（,P,<,0.05），and the treatment group was better than the control group（,P,<,0.05）.After the treatment，the DFI of the treatment group was decreased（,P,<,0.05），which was lower than that of the control group.During the treatment period，2 cases in the experimental group had gastric distension after taking the medicine on an empty stomach，and then changed to take the medicine 1h after meal，and gastric distension disappeared without any other discomfort；in the control group，3 cases had gastric distension after taking the medicine，and the patients stopped taking the medicine by themselves，so they fell off the research.There was no abnormality in blood and urine routine，liver and kidney function in both groups.,Conclusion,2,Yishen Zhongzi Prescription can improve sperm motility and reduce DFI in patients with asthenospermia with kidney and essence deficiency with good clinical effect and safety.

关键词

益肾种子方弱精子证肾虚精亏精子活力DNA碎片率

Keywords

Yishen Zhongzi Prescriptionasthenospermiakidney and essence deficiencysperm motilityDNA fragmentation rate

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