Clinical observation of <italic style="font-style: italic">Guiling Decoction</italic> combined with fire needle therapy in treatment of neurodermatitis

ZHANG Xuan; SUN Zhanxue; ZHANG Lili; MA Shengnan

doi:10.16025/j.1674-1307.2025.10.006

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Clinical observation of Guiling Decoction combined with fire needle therapy in treatment of neurodermatitis

更新时间：2025-12-15

- Clinical observation of Guiling Decoction combined with fire needle therapy in treatment of neurodermatitis
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 10, Pages: 1255-1258(2025)
- 作者机构：
  
  北京中医药大学第三附属医院皮肤性病科，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.10.006
  CLC：
- Received：08 October 2024，
  
  Published：25 October 2025
- 稿件说明：
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张萱，孙占学，张莉莉，等.归苓汤联合火针治疗神经性皮炎临床疗效观察［J］.北京中医药，2025，44（10）：1255-1258.

ZHANG Xuan,SUN Zhanxue,ZHANG Lili,et al.Clinical observation of Guiling Decoction combined with fire needle therapy in treatment of neurodermatitis[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(10):1255-1258.
张萱，孙占学，张莉莉，等.归苓汤联合火针治疗神经性皮炎临床疗效观察［J］.北京中医药，2025，44（10）：1255-1258. DOI： 10.16025/j.1674-1307.2025.10.006.

ZHANG Xuan,SUN Zhanxue,ZHANG Lili,et al.Clinical observation of Guiling Decoction combined with fire needle therapy in treatment of neurodermatitis[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(10):1255-1258. DOI： 10.16025/j.1674-1307.2025.10.006.

摘要

目的

观察归苓汤联合火针治疗神经性皮炎（ND）的临床疗效和安全性。

方法

选择2023年10月—2024年5月就诊于北京中医药大学第三附属医院皮肤性病科门诊的ND患者120例，采用随机数字表法将患者分为观察组和对照组2组，各60例。2组均给予凡士林外涂，2 次/d。对照组口服归苓汤治疗，观察组在口服归苓汤基础上联合火针治疗，疗程4周。对比2组疗效、治疗前后皮损评分、瘙痒程度视觉模拟量表（VAS）评分、阿森斯失眠量表（AIS）评分、伴随症状VAS评分及安全性、复发率。

结果

观察组总有效率高于对照组（

0.05）。治疗4周后，2组瘙痒程度VAS评分、AIS评分、伴随症状VAS评分均低于治疗前（

0.05），且观察组瘙痒程度VAS评分、AIS评分均低于对照组（

0.05）。治疗第2、4周，2组各项皮损评分均较治疗前降低（

0.05），且观察组低于对照组（

0.05）。2组患者均无药物相关不良事件发生；火针治疗后可见创伤结痂，3~10 d可消退。3个月后随访，观察组复发1例，复发率为1.79%；对照组复发4例，复发率为9.09%。2组复发率比较，差异无统计学意义（

0.05）。

结论

归苓汤联合火针治疗神经性皮炎可提高临床疗效，安全性高。

Abstract

Objective

To evaluate the clinical efficacy and safety of

Guiling Decoction

combined with fire needle therapy in the treatment of neurodermatitis （ND）.

Methods

A total of 120 ND patients who visited the Department of Dermatology and Venereology of Beijing University of Chinese Medicine Third Affiliated Hospital from October 2023 to May 2024 were enrolled and randomly assigned into an observation group and a control group （60 patients each） using a random number table. Both groups received topical application of Vaseline twice daily. The control group received oral

Guiling Decoction

， while the observation group was treated with oral

Guiling Decoction

combined with fire needle therapy for 4 weeks. Clinical efficacy， skin lesion scores， Visual Analog

Scale （VAS） for pruritus， Athens Insomnia Scale （AIS） scores， VAS for accompanying symptoms， safety， and recurrence rates were compared between the two groups before and after treatment.

Results

The total effective rate in the observation group was higher than that in the control group （

0.05）. After 4 weeks of treatment， VAS scores for pruritus， AIS scores， and VAS scores for accompanying symptoms decreased in both groups compared with baseline （

0.05）， with the observation group showing greater improvement in VAS scores for pruritus and AIS scores than the control group （

0.05）. Skin lesion scores at weeks 2 and 4 were lower than baseline in both groups （

0.05）， and the observation group had lower scores than the control group （

0.05）. No drug-related adverse events occurred in either group， and scabbing was observed after fire needle therapy， which resolved within 3–10 days. At 3-month follow-up， 1 patient in the observation group relapsed （1.79%）， and 4 patients in the control group relapsed （9.09%）， with no statistically significant difference in recurrence rate between the two groups （

0.05）.

Conclusion

Guiling Decoction

combined with fire needle therapy can improve the clinical efficacy in treating ND and is safe.

关键词

Keywords

references

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Clinical observation of Guiling Decoction combined with fire needle therapy in treatment of neurodermatitis

DOI：10.16025/j.1674-1307.2025.10.006

摘要

Abstract

关键词

Keywords

references