Differentiation and treatment of aplastic anemia based on the pathogenesis theory of marrow depletion with toxin accumulation

LIU Di; WANG Yan; XU Jie; CUI Siyuan; LIU Kui; XU Ruirong

doi:10.16025/j.1674-1307.2025.10.020

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Differentiation and treatment of aplastic anemia based on the pathogenesis theory of marrow depletion with toxin accumulation

更新时间：2025-12-15

- Differentiation and treatment of aplastic anemia based on the pathogenesis theory of marrow depletion with toxin accumulation
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 10, Pages: 1328-1332(2025)
- 作者机构：
  
  1.山东中医药大学第一临床医学院，济南 250011
  2.山东中医药大学附属医院血液科，济南 250014
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.10.020
  CLC：
- Received：09 January 2025，
  
  Published：25 October 2025
- 稿件说明：
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刘迪，王琰，徐杰，等.基于“髓枯毒蕴”辨治再生障碍性贫血的经验［J］.北京中医药，2025，44（10）：1328-1332.

LIU Di,WANG Yan,XU Jie,et al.Differentiation and treatment of aplastic anemia based on the pathogenesis theory of marrow depletion with toxin accumulation[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(10):1328-1332.
刘迪，王琰，徐杰，等.基于“髓枯毒蕴”辨治再生障碍性贫血的经验［J］.北京中医药，2025，44（10）：1328-1332. DOI： 10.16025/j.1674-1307.2025.10.020.

LIU Di,WANG Yan,XU Jie,et al.Differentiation and treatment of aplastic anemia based on the pathogenesis theory of marrow depletion with toxin accumulation[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(10):1328-1332. DOI： 10.16025/j.1674-1307.2025.10.020.

摘要

再生障碍性贫血属于骨髓造血衰竭性疾病，此病发病机制复杂，主要与造血干细胞、骨髓造血微环境以及免疫等因素有关。中医治疗该病有明显优势，多数医家认为肾精亏虚贯穿疾病全程，治疗以补肾益髓为主要方法。徐瑞荣教授认为其病机关键在于“髓枯毒蕴”，邪毒在体内蕴积也会损害骨髓，治疗应当以补肾为根本，解毒为次要，再辅以化瘀。治疗时以益髓解毒为准则，常联合应用中药汤剂和膏方。中药汤剂起效较快，且能够灵活增减药物；膏方以补虚为主，侧重于调理。二者联合使用，相互补充，增强治疗效果。

Abstract

Aplastic anemia （AA） is a bone marrow hematopoietic failure disease with a complex pathogenesis， mainly involving hematopoietic stem cells， the bone marrow hematopoietic microenvironment， and immune factors. Traditional Chinese medicine （TCM） shows significant advantages in treating this disease. Most practitioners consider kidney essence deficiency as the fundamental pathological basis throughout the disease course， with treatment primarily focused on tonifying the kidney and nourishing marrow. Professor XU Ruirong believes the key pathogenesis lies in marrow depletion with toxin accumulation， as internal accumulation of pathogenic toxins can also damage the bone marrow. Treatment should be based on tonifying the kidney as the root， clearing toxins as the secondary approach， and supplemented by resolving stasis. Guided by the principle of nourishing marrow and removing toxin， TCM decoctions are often combined with herbal ointments. Decoctions act quickly and allow flexible modification， while ointments focus on tonifying deficiency and regulating the body. The combination of both therapies is complementary and enhances overall therapeutic efficacy.

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references

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Pathogenesis and treatment of aplastic anemia based on the theory of "essence and blood homology"

Practice and prospect of treating aplastic anemia with integration of traditional Chinese and western medicine mainly with Chinese herbal medicines for tonifying kidney

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