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Clinical efficacy of
Huangjing Jiangya Decoction combined with amlodipine in improving hypertensive patients with anxiety- Beijing Journal of Traditional Chinese Medicine Vol. 45, Issue 1, Pages: 1-5(2026)
- 作者机构：
1.北京中医药大学东方医院经开区院区综合内科，北京 100078
2.北京市第六医院中医科，北京 100007
3.西安医学院公共卫生学院，西安 710021
- 作者简介：
- 基金信息：
DOI：10.16025/j.1674-1307.2026.01.001
CLC：Received：26 June 2024，
Published：25 January 2026
- 稿件说明：
移动端阅览
史雯，马海娟，何晋涛，等.黄精降压汤联合氨氯地平治疗高血压病患者合并焦虑状态的效果观察［J］.北京中医药，2026，45（1）：1-5.
SHI Wen,MA Haijuan,HE Jintao,et al.Clinical efficacy of Huangjing Jiangya Decoction combined with amlodipine in improving hypertensive patients with anxiety[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(01):1-5.
史雯，马海娟，何晋涛，等.黄精降压汤联合氨氯地平治疗高血压病患者合并焦虑状态的效果观察［J］.北京中医药，2026，45（1）：1-5. DOI： 10.16025/j.1674-1307.2026.01.001.
SHI Wen,MA Haijuan,HE Jintao,et al.Clinical efficacy of Huangjing Jiangya Decoction combined with amlodipine in improving hypertensive patients with anxiety[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(01):1-5. DOI： 10.16025/j.1674-1307.2026.01.001.
摘要
目的
2
观察黄精降压汤联合氨氯地平治疗高血压病患者合并焦虑状态的效果。
方法
2
选择2022年5月—2023年11月北京市第六医院中医科、心内科及神经内科门诊收治的气虚型原发性高血压合并焦虑状态患者71例，随机分为观察组、对照组。对照组给予西医常规治疗，口服苯磺酸氨氯地平片5 mg，1次/d；观察组在对照组基础上给予自拟黄精降压汤口服。2组均连续治疗8周。观察比较2组临床疗效及治疗前后诊室血压、家庭血压、动态血压、广泛性焦虑量表（GAD-7）评分、中医证候积分情况。
结果
2
治疗后观察组临床疗效总有效率、中医证候总有效率高于对照组（均
P
<
0.01）。治疗后，观察组诊室血压、家庭血压均较治疗前降低（
P
<
0.05），且均低于对照组（
P
<
0.01）；观察组24 h SBP、DBP较治疗前降低（
P
<
0.05），且均低于对照组（
P
<
0.01）；观察组GAD-7评分较治疗前降低（
P
<
0.05），且低于对照组（
P
<
0.01）；观察组中医证候积分较治疗前降低（
P
<
0.05），且低于对照组（
P
<
0.01）。2组治疗过程中均未见恶心、呕吐等不良反应，肝、肾功能指标等均未见异常。
结论
2
黄精降压汤联合氨氯地平可明显降低气虚型高血压病合并焦虑状态患者的血压，改善其焦虑状态和临床症状，整体疗效优于单纯氨氯地平治疗，且安全性高。
Abstract
Objective
2
To observe the clinical efficacy of
Huangjing Jiangya Decoction
combined with amlodipine in treating patients with hypertension complicated by anxiety.
Methods
2
A total of 71 patients with primary hypertension of
qi
-deficiency type and comorbid anxiety， treated at the Traditional Chinese Medicine， Cardiology， and Neurology Outpatient Departments of Beijing Sixth Hospital from May 2022 to November 2023， were randomly divided into an observation group and a control group. The control group received conventional Western medicine treatment with amlodipine besylate tablets 5 mg once daily. The observation group received additional oral administration of self-formulated
Huangjing Jiangya Decoction
on top of the control regimen. Both groups were treated continuously for 8 weeks. Clinical efficacy， clinic blood pressure， home blood pressure， 24-hour ambulatory blood pressure， GAD-7 score， and TCM syndrome scores before and after treatment were compared between the two groups.
Results
2
After treatment， the total clinical efficacy and total TCM syndrome efficacy in the observation group were higher than those in the control group （both
P
<
0.01）. Clinic and home blood pressure in the observation group were significantly reduced compared to baseline （both
P
<
0.05） and were lower than those in the control group （both
P
<
0.01）. The 24-hour systolic and diastolic blood pressure in the observation group decreased significantly compared to baseline （both
P
<
0.05） and were lower than those in the control group （both
P
<
0.01）. The GAD-7 score and TCM syndrome scores in the observation group were significantly lower than before treatment （both
P
<
0.05） and lower than in the control group （both
P
<
0.01）. No adverse reactions such as nausea or vomiting were observed during treatment， and liver and kidney function indicators remained normal in both groups.
Conclusion
2
Huangjing Jiangya Decoction
combined with amlodipine can significantly reduce blood pressure， improve anxiety symptoms and clinical manifestations in patients with
qi
-deficiency hypertension and anxiety， with overall efficacy superior to amlodipine alone， and demonstrates high safety.
关键词
Keywords
references
中国高血压防治指南(2018年修订版) [J ] . 中国心血管杂志 ， 2019 ， 24 ( 1 )： 24 - 56 ．
PAN Y , CAI W , CHENG Q , et al . Association between anxiety and hypertension: a systematic review and meta-analysis of epidemiological studies [J ] . Neuropsychiatr Dis Treat , 2015 , 11 : 1121 - 1130 .
BHATTACHARYA R , SHEN C , SAMBAMOORTHI U . Excess risk of chronic physical conditions associated with depression and anxiety [J ] . BMC Psychiatry , 2014 , 14 : 10 .
HO AK , THORPE CT , PANDHI N , et al . Association of anxiety and depression withhypertension control:a US multidisciplinary group practice observational study [J ] . J Hypertens , 2015 , 33 ( 11 ): 2215 - 2222 .
汪紫妍 , 诸国华 , 华琦 . 高血压患者抑郁焦虑共病的研究进展 [J ] . 中华保健医学杂志 , 2021 , 23 ( 3 ): 307 - 310 .
王谨敏 , 周小炫 , 吴成翰 , 等 . 中医治未病·高血压伴发焦虑专家共识 [J ] . 中华中医药学刊 , 2020 , 38 ( 3 ): 29 - 32 .
孙毅 , 田国祥 , 石克威 , 等 . 舒肝解郁胶囊与草酸艾司西酞普兰治疗高血压合并焦虑、抑郁的对照研究 [J ] . 中国循证心血管医学杂志 , 2018 , 10 ( 12 ): 1478 - 1479,1487 .
姜瑜 , 刘珊 , 袁天翊 , 等 . 复方利血平氨苯蝶啶片调节大鼠肠道菌群抗高血压实验研 [J ] . 中国新药杂志 , 2022 , 31 ( 11 ): 1057 - 1065 ．
黄汉菊 , 卢建雄 , 杨月嫦 . 缬沙坦联合氨氯地平治疗社区原发性高血压的临床疗效及安全性 [J ] . 中国老年学杂志 , 33 ( 9 )： 2154 - 2155 .
马小丽 . 孔嗣伯辨证治疗高血压病经验 [J ] . 北京中医药 , 2022 , 41 ( 12 ): 1381 - 1383 .
林萍 , 崔伟锋 , 雷斯媛 , 等 . 中医药治疗高血压与焦虑症共病的临床疗效研究 [J ] . 世界中医药 , 2023 , 18 ( 17 ): 2488 - 2491,2497 .
PLUMMER F , MANEA L , TREPEL D , et al . Screening for an-xiety disorders with the GAD-7 and GAD-2:a systematic review and diagnostic metaanalysis [J ] . Gen Hosp Psychiatry , 2016 , 39 : 24 - 31 .
中国高血压防治指南修订委员会 , 高血压联盟(中国 , 中国医疗保健国际交流促进会高血压病学分会 , 等 . 中国高血压防治指南(2024年修订版) [J ] . 中华高血压杂志 , 2024 , 32 ( 7 ): 603 - 700 .
美国精神医学学会 . 精神障碍诊断与统计手册 [M ] . 5版 . 北京 ： 北京大学出版社 , 2014 : 38 .
国家中医药管理局 . 中医病症诊断疗效标准 [M ] . 南京 : 南京大学出版社 , 1999 : 19 , 23 .
SOUSA TV , VIVEIROS V , CHAI MV , et al . Reliability and validity of the portuguese version of the generalized anxiety disorder (GAD-7) scale [J ] . Health Qual Life Outcomes , 2015 , 13 : 50 .
郑筱萸 . 中药新药临床研究指导原则:试行 [M ] . 北京 : 中国医药科技出版社 , 2002 : 75 .
POLANCZYK GV , SALUM GA , SUGAYA LS , et al . Annual research review:a meta analysis of the worldwide prevalence of mental disorders in children and adolescents [J ] . J Child Psychol Psychiatry , 2015 , 56 ( 3 ): 345 - 365 .
SANTOS-VELOSO M , MELO M , CAVALCANTI R , et al . Prevalence of depression and anxiety and their association with cardiovascular risk factors in northeast brasil primary care patients [J ] . Rev Assoc Med Bras , 2019 , 65 ( 6 ): 801 - 809 .
刘思源 , 黎红华 , 骆文静 , 等 . 高血压患者失眠与焦虑抑郁的共病临床分析 [J ] . 神经损伤与功能重建 , 2021 , 16 ( 2 ): 114 - 115,120 .
王静 , 陈洁 . 高血压合并焦虑、抑郁患者血清炎症因子和单胺类递质水平的变化 [J ] . 中华高血压杂志 , 2023 , 31 ( 8 ): 769 - 772 .
张海娟 , 田国祥 , 翟玉翠 , 等 . 焦虑抑郁情绪对高血压病患者血压变异性及血管内皮细胞功能的影响 [J ] . 中国医药 , 2023 , 18 ( 8 ): 1140 - 1144 .
查玉玲 , 李军 . 高血压靶器官损害的中医临床研究进展 [J ] . 北京中医药 , 2021 , 40 ( 4 ): 436 - 439 .
丛晓荣 , 秦景梅 , 高莉 . 心可舒片联合降压治疗对原发性高血压合并焦虑抑郁患者血压和血压变异性及焦虑抑郁程度的影响 [J ] . 中国医药 , 2022 , 17 ( 6 ): 814 - 817 .
屈晨 , 冯辉 . 医药治中疗原发性高血压伴焦虑的研究进展 [J ] . 天津中医药 , 2016 , 33 ( 3 ): 185 - 188 .
罗山河 , 黄凯琳 , 王茜 , 等 . 逍遥散加减辅助治疗高血压病合并焦虑抑郁有效性与安全性的Meta分析 [J ] . 中国医药 , 2023 , 18 ( 12 ): 1863 - 1868 .
胡启芬 , 魏科 , 马彪 , 等 . 吴荣中医论治原发性高血压病经验 [J ] . 中医临床研究 , 2023 , 15 ( 17 ): 66 - 69 .
黄莺 , 徐维平 , 张许来 , 等 . 黄精结合米氮平治疗老年脑梗死后抑郁症的临床研究 [J ] . 安徽医药 , 2017 , 21 ( 9 ): 1702 - 1705 ．
刘松林 . 钩藤总生物碱的抗抑郁作用及其血清药物化学初步研究 [D ] . 广州 : 广东药科大学 , 2018 .
刘海艳 , 冯斌 , 王济 , 等 . 天麻素对抑郁症模型小鼠抑郁行为及其相关细胞因子表达的影响 [J ] . 中南药学 , 2018 , 16 ( 2 ): 166 - 170 ．
孙润珠 , 周翠红 , 薛姗姗 , 等 . 天麻素对CUS大鼠抑郁样行为及IL-1β和IL-6水平的影响 [J ] . 神经解剖学杂志 , 2017 , 33 ( 2 ): 221 - 224 .
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