Objective

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To explore the distribution characteristics of disease onset across solar terms in three syndrome types of infantile cytomegalovirus hepatitis， and to provide a theoretical basis for disease prevention and management from the perspectives of chronomedicine and the theory of correspondence between humans and nature.

Methods

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A total of 360 infants with cytomegalovirus hepatitis who visited the Department of Traditional Chinese Medicine at Beijing Children’s Hospital， Capital Medical University， from January 2019 to February 2024 were enrolled. According to traditional Chinese medicine （TCM） syndrome differentiation， the patients were divided into three groups： dampness-heat internal accumulation syndrome， spleen deficiency with dampness retention syndrome， and

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stagnation with blood stasis syndrome， with 120 cases in each group. Based on the dates of disease onset， frequency analysis and line charts were used to statistically analyze the seasonal and solar-term distributions of onset among different syndrome types.

Results

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The onset of infantile cytomegalovirus hepatitis was mainly concentrated in winter and spring， with solar terms predominantly occurring during Chunfen （Spring Equinox）， Qingming （Pure Brightness）， Guyu （Grain Rain）， Xiaohan （Slight Cold）， and Dahan （Great Cold）. In the dampness-heat internal accumulation syndrome group， onset was mainly concentrated in spring and summer， with Qingming， Guyu， Xiazhi （Summer Solstice）， Xiaoshu （Slight Heat）， and Dashu （Great Heat） being the most common solar terms. In the spleen deficiency with dampness retention syndrome group， onset occurred mainly in spring and winter， with Qingming， Guyu， Xiaohan， and Dahan being predominant. In the

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stagnation with blood stasis syndrome group， onset was also mainly concentrated in spring and winter， with Lichun （Beginning of Spring）， Jingzhe （Waking of Insects）， Chunfen， Xiaohan， and Dahan being the most common solar terms.

Conclusion

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The onset of infantile cytomegalovirus hepatitis in the three syndrome types shows distinct seasonal and solar-term distribution characteristics.