最新刊期
期 2 ， 2022
- 摘要：ObjectiveTo explore the clinical effect of Jianpi Huashi Zhixue Prescription for patients with hepatitis B cirrhosis accompanied with esophagogastric variceal bleeding (EGVB) within one year.MethodsA total of 110 patients with EGVB cirrhosis admitted to Beijing Ditan Hospital Affiliated to the Capital Medical University from May 2018 to May 2020 were selected and randomly divided into integrated traditional Chinese and western medicine treatment group and western medicine control group of 55 in each one, the course of treatment was 12 weeks with 48 weeks of following up.The re-bleeding rate,liver function and the changes of TCM syndrome score of two groups were observed.ResultsAfter 48 weeks of follow-up,the bleeding rate was 45.5% in the group of integrated traditional Chinese and western medicine and 63.6% in the control group.There was statistical difference between the two groups (P<0.05).After treatment,the liver function in 2 groups was both improved,ALT,AST and TBIL were decreased,but there was no statistical difference(P>0.05).The ALB level of patients in the integrated traditional Chinese and western medicine treatment group after treatment was significantly higher than that in the control group,with statistical difference(P<0.05).After 8 weeks of treatment,the TCM syndrome score in the integrated Chinese and western medicine group was significantly lower than that in the western medicine control group,the difference was statistically significant(P<0.05).ConclusionJianpi Huashi Zhixue Prescription can improve the liver function,promote protein synthesis and TCM symptoms in patients with hepatitis B cirrhosis,thereby reducing the risk of re-bleeding in those patients with EGVB within 1 year.关键词：Jianpi Huashi Zhixue Prescription;hepatitis B;liver cirrhosis;esophageal and gastric varices bleeding;therapeutic method of TCM
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发布时间：2023-02-15 - 摘要：ObjectiveTo observe and evaluate the clinical efficacy of traditional Chinese medicine with gastroscopy mucosa syndrome differentiation in the treatment of children with abdominal type allergic purpura (HSP).MethodsUsing prospective and randomized controlled clinical research methods,100 children with HSP (abdominal type) of the syndrome of interior accumulation of dampness and toxin were randomly divided into treatment group (TCM syndrome differentiation group)of 50 cases,and control group (TCM syndrome differentiation combined with gastroscope mucosa analysis group)of 50 cases. During treatment, 8 cases drop out, so finally there were 46 cases in each groups. Both groups were given hormone and other conventional western medicine,while apart from western medicine treatment, the control group was also given Qingzi Zhitong Decoction orally. In the treatment group,on the basis of the combination of traditional Chinese and western medicine treatment,micro syndrome differentiation was made according to the observation of mucosa under gastroscope,and then Chinese herbal medicines were adjusted. The course of treatment was 2 weeks. The symptom and sign before and after treatment were scored, the disappearance time of abdominal pain and the changes of WBC, CRP, ESR and D-dimer before and after treatment were observed in order to determine the clinical efficacy.ResultsAfter treatment, the treatment group was higher than that of the control group in the recovery rate,abdominal pain and abdominal distension scores were lower than that of the control group, abdominal pain relief time was shorter than that of the control group and D-dimer concentration was lower than that of the control group with the differences statistically significant (P<0.05).ConclusionTraditional Chinese medicine combined with gastroscope mucosa differentiation can be further optimized for the treatment of abdominal allergic purpura with interiorly accumulated dampness and toxin.关键词：Abdominal anaphylactoid purpura;interiorly accumulated dampness and toxin;mucosal image;gastroscope;microscopic syndrome differentiation
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发布时间：2023-02-15 - 摘要：ObjectiveTo observe the clinical efficacy of Runjidan Oil in the treatment of diabetic foot ulcer.MethodsA Total of 60 cases of diabetic foot ulcer patients were selected and randomly divided into observation group and control group （30 cases each）. After basic treatment and conventional surgical debridement， the observation group was treated with Runjidan Oil gauze for dressing， while the control group was treated with Kangfuxin Liquid gauze for dressing. The two groups were treated with 7 days as one course of treatment， and a total of 4 courses were observed. The changes of TCM syndrome score， wound area， ankle-brachial index， WBC and CRP values in peripheral blood of two groups before and after treatment were compared， and the total clinical effective rate was observed.ResultsThe total clinical effective rate was 86.67% in the observation group and 73.33% in the control group， the difference was statistically significant （P<0.05）.Since the 7th day of treatment， TCM syndrome score and wound area in both groups were lowered than before treatment.The reduction in the observation group was more significant than that in the control group at all time points after treatment， and the wound area reduction rate was higher than that in the control group at 28 days after treatment， the differences were all statistically significant （P<0.05）. Since the 7th day of treatment， the levels of WBC and CRP in peripheral blood of both groups were lower than before， and the decrease was more obvious in the observation group. Since the 21st day of treatment， the difference between the two groups was statistically significant （P<0.05）.There was no significant difference in ankle-brachial index between the two groups before and after treatment （P>0.05）， the ankle-brachial index in both groups were decreased after 28 days of treatment， and the difference was statistically significant （P<0.05）.ConclusionRunjidan Oil when used in the treatment of diabetic foot ulcer can accelerate the healing of the wound and has a good clinical effect.关键词：Diabetic foot;ulcer;Runjidan Oil
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发布时间：2023-02-15 - 摘要：ObjectiveTo explore the effect of puerarin on oxidative stress and mitochondrial damage in human immortal podocytes induced by H2O2 under high glucose environment and its mechanism.MethodsHuman immortal podocytes were stimulated with different concentrations of H2O2 in a high-glucose environment, and intervened by different concentrations of puerarin for 48 hours. The groups were divided as follows: group H0 (H2O2 0 μmol/L), group H100 (H2O2 100 μmol/L), group H100+P3.3(H2O2 100 μmol/L+ puerarin 3.3 μmol/L), group H100+ P10 (H2O2 100 μmol/L+ puerarin 10 μmol/L), group H200 (H2O2 200 μmol/L), group H200+P3.3(H2O2 200 μmol/L+ puerarin 3.3 μmol/L), group H200+P10(H2O2 200 μmol/L+puerarin 10 μmol/L). CCK-8 was used to detect cell viability. Western blotting was used to detect the protein expression of TOMM22; Genomic DNA was extracted and qPCR was used to detect the expression of mtDNA; RNA was extracted and qPCR was used to detect the mRNA expression of TFAM and NRF1;the levels of ATP and ROS in each group were measured and the mitochondrial respiratory function were evaluated.ResultsCompared with H0 group, ROS level was increased in H100 and H200 groups (P<0.01), mtDNA copy number was decreased in H100 and H100+P3.3 groups (P<0.01), TFAM mRNA expression was decreased, basal respiration, proton leakage, maximum oxygen consumption and non-mitochondrial oxygen consumption were increased (P<0.05). Compared with H100 group, ROS in H100+P3.3 group was decreased (P<0.05), TFAM mRNA and NRF1 mRNA expression were increased (P<0.05, P<0.01), ATP production was increased (P<0.05), basal respiration and proton leakage were decreased (P<0.05) in group H100+P3.3. In H100+P10 group, mtDNA copy number was increased (P<0.05), NRF1 mRNA, basal respiration, proton leakage and non-mitochondrial consumption were increased (P<0.05). Compared with H100+P3.3 group, the mtDNA copy number of H100+P10 group was significantly increased (P<0.01), basal respiration, proton leakage, non-mitochondrial oxygen consumption and ATP levels were increased (P<0.05). Compared with H200 group, ROS levels in H200+P3.3 and H200+P10 groups were significantly decreased (P<0.01), NRF1 mRNA expression was increased (P<0.01) and non-mitochondrial oxygen consumption was increased (P<0.05) in H200+P10 group. Compared with H200+P3.3 group, ROS level in H200+P10 group increased (P<0.01), TFAM mRNA expression increased (P<0.05), NRF1 mRNA expression increased (P<0.01). There were no statistically significant differences in TOMM22 protein expression, reserve respiratory capacity, coupling efficiency and reserve respiratory rate among all groups (P>0.05).ConclusionPuerarin can partially relieve podocyte oxidative stress and mitochondrial damage induced by high glucose and H2O2.关键词：Puerarin;diabetic kidney disease;oxidative stress;mitochondrial damage
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发布时间：2023-02-15 - 摘要：ObjectiveTo observe the effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury （MIRI） in rats .MethodsSD rats were randomly divided into sham，model, Compound Danshen Tablet 1.26 g/kg (control group) and Shenyuan Yiqi Huoxue Capsule groups of low dosage 1.08 g/kg， medium dosage 2.16 g/kg，and large dosage 4.31 g/kg. The MIRI model was established by the ligation of the left anterior descending coronary artery 30 min and the release 120 min in rats. Serum AST, LDH,CK-MB, CK, Na+-K+-ATPase, Ca2+-Mg2+-ATPase, PGI2, TX-A2, SOD, MDA were measured.ResultsCompared with the model group， Shenyuan Yiqi Huoxue Capsule group of high dosage can significantly inhibit serum AST, CK, LDH, TX-A2 and MDA content， improve Na+-K+-ATPase, Ca2+-Mg2+-ATPase, PGI2 and SOD activity（P<0.01，P<0.05）；medium group can inhibit serum CK and LDH content， improve SOD activity （P<0.01，P<0.05).ConclusionShenyuan Yiqi Huoxue Capsule has a protective effect on MIRI myocardium in rats.关键词：Shenyuan Yiqi Huoxue Capsule;myocardial ischemia–reperfusion injury;myocardial enzymes;rat
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发布时间：2023-02-15 - 摘要：ObjectiveTo investigate the effect and the related mechanism of electroacupuncture in mouse model with Alzheimer's disease （AD）.Methods60 SPF C57BL/6 mice were randomly divided into control group （n=20）， AD model group （n=20） and electroacupuncture group （n=20）. AD model group and electroacupuncture group were established by utilizing D-galactose subcutaneously injection and joint intraperitoneal injection of sodium nitrite. From the 2nd day after modeling，the electroacupuncture group received electroacupuncture treatment once a day with 6 days as 1 course and 2 treatment courses given in total. The other group of rats were only captured without electroacupuncture. On the second day after the electroacupuncture treatment，the Morris water maze test was used to evaluate the cognitive ability in different groups. After Morris water maze test，the mice were deprived food and water for 12 h before sampling， and the content of NLRP3， TNF-α and IL-1 in hippocampal tissues of three groups were detected by ELISA，and the expression levels of NLRP3 mRNA were measured by RT-PCR .ResultsThe escape incubation period were increased，and the number of times crossing the platform，the duration of stay in the target quadrant and the percentage of stay in the platform quadrant in the total distance were significantly reduced in the AD model group than those in the normal control group （P<0.05）； compared with the AD model group， the escape incubation period were reduced，and the number of times crossing the platform，the duration of stay in the target quadrant and the percentage of stay in the platform quadrant in the total distance were increased in the electroacupuncture groups （P<0.05）； the contents of the NLRP3，TNF-α and IL-1β in the hippocampus were decreased significantly（P<0.05）.ConclusionElectroacupuncture could significantly reduce the expression levels of NLRP3 AD mice，which can inhibit the neuroinflammatory response in the brain by down-regulating NLRP3，so as to significantly relieve the symptoms of learning and memory impairment in AD mice.关键词：Alzheimer's disease;electroacupuncture;NLRP3;inflammasome;mouse
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发布时间：2023-02-15 -
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