最新刊期
卷 44 ， 期 10 ， 2025
- 摘要：ObjectiveTo analyze the predisposed traditional Chinese medicine （TCM） constitution and risk factors of diabetic macrovascular complications， and to construct a clinical risk prediction model.MethodsA total of 275 hospitalized diabetic patients admitted to Wuyi Hospital of Traditional Chinese Medicine， Jiangmen City， affiliated with Jinan University， from December 2023 to June 2024 were included， of whom 173 patients with imaging-confirmed macrovascular disease were assigned to the observation group and 102 patients without macrovascular disease to the control group. TCM constitution types were assessed using a standardized questionnaire. Binary logistic regression analyses were performed to identify influencing factors and independent risk factors for diabetic macrovascular complications. Data were imported into R4.3.2 software， and a nomogram prediction model was constructed using the rms package based on the identified risk factors. Model performance was evaluated using calibration curves， receiver operating characteristic （ROC） curves and area under the curve （AUC）， goodness-of-fit test， and decision curve analysis （DCA）.ResultsUnivariate and multivariate logistic regression analyses indicated that qi deficiency constitution was the predisposition for diabetic macrovascular complications （P<0.05）. Gender， age， history of hyperuricemia， and history of hypertension were independent risk factors （P<0.05）. The prediction model based on multivariate analysis was expressed as： Logit P=age×0.093+history of hypertension×1.033+history of hyperuricemia×0.958+gender×0.989+qi deficiency constitution×0.926－6.741. Incorporating the predisposed constitution and independent risk factors into R software， a nomogram for diabetic macrovascular complications was constructed. The ROC curve analysis showed that the AUC of this prediction model for predicting the incidence of diabetic macrovascular complications was 0.82（95%CI：0.764-0.871）， indicating good discrimination. The calibration curve closely aligned with the ideal curve， suggesting good agreement between predicted and observed outcomes. The Hosmer-Lemeshow test showed χ2=8.389，P=0.396， indicating good model fit. Decision curve analysis demonstrated clinical utility， with better performance than any single risk factor.ConclusionQi deficiency constitution is closely associated with diabetic macrovascular complications. The nomogram based on qi deficiency， gender， age， history of hyperuricemia， and history of hypertension provides valuable clinical reference for predicting the risk of diabetic macrovascular complications.关键词：diabetic macrovascular complications;traditional Chinese medicine constitution;risk factors;risk prediction model2|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo observe the tongue image characteristics of phlegm-blood stasis syndrome in patients with stable angina pectoris of coronary heart disease， and to investigate factors influencing these tongue features.MethodsFrom May 2022 to January 2023， a total of 90 patients with stable angina pectoris of coronary heart disease were enrolled at Xiyuan Hospital， China Academy of Chinese Medical Sciences， including 47 patients with phlegm-blood stasis syndrome （phlegm-blood stasis group） and 43 patients without phlegm-blood stasis syndrome （non-phlegm-blood stasis group）. Tongue images were collected using a tongue diagnostic instrument and analyzed， and potential influencing factors were assessed.ResultsSignificant differences were observed between the two groups in tongue coating and sublingual collaterals （P<0.05）. The phlegm-blood stasis group predominantly had greasy coatings， while the non-phlegm-blood stasis group predominantly had thin coatings. Sublingual collaterals in the phlegm-blood stasis group were mainly moderately to severely tortuous， whereas the non-phlegm-blood stasis group showed mostly mild to moderate tortuosity. No significant differences were found in the tongue tip RGB values between the two groups （P>0.05）， but the tongue body stasis index was significantly higher in the phlegm-blood stasis group （P<0.05）. Age， alcohol consumption， triglycerides （TG）， and LDL-C had no effect on thin coating in phlegm-blood stasis patients （P>0.05）； age was an independent factor influencing greasy coating （P<0.05）； smoking history was an independent factor affecting the tongue body stasis index （P<0.05）.ConclusionPatients with stable angina pectoris of coronary heart disease and phlegm-blood stasis syndrome exhibit thicker and greasy tongue coatings， sublingual collaterals that are moderately to severely tortuous， and higher tongue body stasis index. Age influences the presence of greasy coating， and smoking history affects the tongue body stasis index.关键词：coronary heart disease;phlegm-blood stasis syndrome;tongue diagnosis;tongue image characteristics;influencing factors2|0|0更新时间：2025-12-15
- 摘要：The Wuzang organs pulse and the four-seasons pulse are important components of pulse diagnosis in Huangdi Neijing， with the heart vessel pulse being a key part. According to the Pulse Classic （Maijing）， it is located at the "left inch" position， that is， within one inch between the radial tuberosity of the left wrist and the thenar eminence along the radial artery. Later physicians largely based their pulse-taking methods on this position. In terms of pulse characteristics， a "hooked" heart vessel pulse is considered normal， whereas excess or deficiency indicates pathology， reflecting the state of exuberance and decline of yin and yang in the heart and its pathomechanisms， and carrying important significance for clinical diagnosis and treatment. This article collects and explores content related to the heart vessel pulse from the Huangdi Neijing， Classic of Difficulties （Nanjing）， Pulse Classic， Treatise on Cold Damage （Shanghanlun）， and Important Formulas Worth a Thousand Gold Pieces （Qianjinfang）， aiming to provide a reference for future scholars.关键词：Pulse Classic;pulse of Wuzang organs;four-seasons pulse2|0|0更新时间：2025-12-15
- 摘要：The essence of "Yingwei tilting" lies in the imbalance of nutrient and defense， representing a dynamic pathological change in their circulation and distribution across time and space. "Yingwei tilting" encompasses Yingwei disharmony， Yingwei obstruction， and Yingwei insufficiency， which are the core mechanisms in the pathogenesis of coronary microvascular diseases. This paper focuses on these three aspects to guide intervention and regulation， and constructs a basic diagnostic and treatment approach for coronary microvascular disease based on harmonizing nutrient and defense， resolving blood stasis， promoting qi and diuresis， and dredging and tonifying collaterals and vessels.关键词：Yingwei tilting;coronary microvascular diseases;syndrome differentiation and treatment2|0|0更新时间：2025-12-15
- 摘要：In traditional Chinese medicine （TCM）， the etiology and pathogenesis of hypertrophic cardiomyopathy can be explained from the perspectives of endowment and stasis-toxin. This article divides the disease course into three stages. In the early stage， poor endowment， a tendency toward deficiency and stasis， and latent stasis and toxin form the basis of pathogenesis. In the progressive stage， the key pathological mechanisms include the entanglement of stasis and toxin， obstruction of the collaterals by stasis， and toxin-induced damage to the heart. In the late stage， the combination of stasis and toxin， blockage of blood and qi， and exhaustion of yang and yin result in critical consequences. The diagnostic and therapeutic approach is as follows： in the early stage， identify endowment predispositions and regulate body constitution to achieve prevention； in the progressive stage， focus on activating blood circulation to resolve stasis， reinforcing healthy qi， and removing toxin， with modifications based on syndrome differentiation； in the late stage， promote detoxification and dredge obstructions while preserving primordial qi to manage critical and variable conditions.关键词：hypertrophic cardiomyopathy;endowment;stasis and toxin;etiology and pathogenesis;treatment principles and therapeutic methods2|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo evaluate the clinical efficacy and safety of Guiling Decoction combined with fire needle therapy in the treatment of neurodermatitis （ND）.MethodsA total of 120 ND patients who visited the Department of Dermatology and Venereology of Beijing University of Chinese Medicine Third Affiliated Hospital from October 2023 to May 2024 were enrolled and randomly assigned into an observation group and a control group （60 patients each） using a random number table. Both groups received topical application of Vaseline twice daily. The control group received oral Guiling Decoction， while the observation group was treated with oral Guiling Decoction combined with fire needle therapy for 4 weeks. Clinical efficacy， skin lesion scores， Visual Analog Scale （VAS） for pruritus， Athens Insomnia Scale （AIS） scores， VAS for accompanying symptoms， safety， and recurrence rates were compared between the two groups before and after treatment.ResultsThe total effective rate in the observation group was higher than that in the control group （P<0.05）. After 4 weeks of treatment， VAS scores for pruritus， AIS scores， and VAS scores for accompanying symptoms decreased in both groups compared with baseline （P<0.05）， with the observation group showing greater improvement in VAS scores for pruritus and AIS scores than the control group （P<0.05）. Skin lesion scores at weeks 2 and 4 were lower than baseline in both groups （P<0.05）， and the observation group had lower scores than the control group （P<0.05）. No drug-related adverse events occurred in either group， and scabbing was observed after fire needle therapy， which resolved within 3–10 days. At 3-month follow-up， 1 patient in the observation group relapsed （1.79%）， and 4 patients in the control group relapsed （9.09%）， with no statistically significant difference in recurrence rate between the two groups （P>0.05）.ConclusionGuiling Decoction combined with fire needle therapy can improve the clinical efficacy in treating ND and is safe.关键词：Guiling Decoction;fire needle therapy;neurodermatitis2|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo observe the clinical efficacy of traditional Chinese medicine （TCM） therapy combined with the POLICE principle （Protection with brace， Optimal Loading， Ice， Compression， Elevation） in treating acute lateral ankle ligament injury.MethodsSixty patients with acute lateral ankle ligament injury treated at Wangjing Hospital of China Academy of Chinese Medical Sciences from June 2024 to February 2025 were enrolled and randomly divided into an observation group and a control group， with 30 patients in each group， using a random number table. Both groups received POLICE principle-based management. The control group was treated with topical diclofenac diethylamine emulgel， while the observation group received comprehensive TCM therapy. The treatment course was 3 weeks. Patients were instructed to undergo ankle rehabilitation training 4–6 weeks post-injury. The American Orthopaedic Foot & Ankle Society （AOFAS） score and Karlsson score were assessed before treatment， at 3 weeks post-injury， and at 6 weeks post-injury. MRI scores of the affected ankle and the signal-to-noise ratio （SNR） in the anterior talofibular ligament region were measured before treatment and at 3 months post-injury.ResultsAt 3 weeks post-injury， the observation group had significantly higher AOFAS and Karlsson scores than the control group （P<0.05）. At 3 months post-injury， SNR in the observation group was lower than that in the control group （P<0.05）. No acupuncture-related adverse reactions such as dizziness or needle retention were observed during the treatment period. No local reactions such as redness， swelling， or itching of the affected ankle were observed during the treatment or within 1 week after treatment completion.ConclusionTCM therapy combined with the POLICE principle facilitates ligament repair and functional recovery of the ankle in patients with acute lateral ankle ligament injury and demonstrates a favorable safety profile.关键词：POLICE principle;integrated traditional Chinese and western medicine;lateral ankle ligament injury;joint function;signal-to-noise ratio2|0|0更新时间：2025-12-15
- 摘要：ObjectiveBased on resting-state functional magnetic resonance imaging （rs-fMRI）， this study observed the effects of plum-blossom needling on myopia in children and adolescents and explored the neural mechanism in the visual cortex using functional connectivity （FC） analysis.MethodsA total of 80 children aged 6–12 years with low-to-moderate myopia （160 eyes） who visited the Optometry Center and Ophthalmology Department of Eye Hospital of China Academy of Chinese Medical Sciences between February 2023 and April 2024 were enrolled. Using a randomized controlled， single-blind design， participants were randomly assigned to Group 1 （n=40） or Group 2 （n=40） by random number table. Group 1 received plum-blossom needle tapping at Dazhui （GV 14）， Baihui （GV 20）， bilateral Cuanzhu （BL 2）， Yuyao （EX-HN 4）， Taiyang （EX-HN 5）， Muchuang （GB 16）， Fengchi （GB 20）， Hegu （LI 4）， and Neiguan （PC 6）. Group 2 received tapping at bilateral Cuanzhu （BL 2）， Yuyao （EX-HN 4）， Sizhukong （TE 23）， Taiyang （EX-HN 5）， Sibai （ST 2）， Zhengguang 1， Zhengguang 2， and Yangbai （GB 14）. Treatments were administered twice weekly for 10 min each session over a total course of 12 weeks. Changes in uncorrected visual acuity （UCVA）， diopter， corneal curvature， and axial length （AL） were compared between the two groups before and after treatment. Children in Group 1 who consented underwent cranial rs-fMRI scans before treatment and 1 month after treatment.ResultsAfter treatment， UCVA in Group 1 was superior to Group 2 （P<0.05）. There were no significant differences in diopter or mean corneal curvature between the two groups （P>0.05）. AL increased in both groups compared with baseline （P<0.01）， and the overall effective rate was higher in Group 1 than in Group 2 （P<0.05）. In Group 1， brain regions with enhanced FC included left V1 with left lingual gyrus and left calcarine fissure surrounding cortex， right V2 with superior frontal gyrus， left V3 with right superior occipital gyrus and right cuneus， right V3 with left superior occipital gyrus and left middle occipital gyrus （P<0.01， FWE corrected）. Brain regions with decreased FC included right V1 with left middle temporal gyrus， left angular gyrus， and left middle occipital gyrus （P<0.01， FWE corrected）. Positive correlations between left V2 FC and visual acuity were observed in the left superior parietal gyrus， right paracentral lobule， left paracentral lobule， left precuneus， left superior occipital gyrus， and left cuneus.ConclusionPlum-blossom needle therapy can improve uncorrected visual acuity and is effective in treating myopia in children and adolescents. Its mechanism may involve modulation of FC in the occipital visual cortex and adjacent brain regions， with left V2 FC showing a positive correlation with visual acuity.关键词：plum-blossom needling;myopia;children and adolescents;resting-state functional magnetic resonance imaging;functional connectivity2|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo observe the effects of rotational-traction manipulation combined with acupuncture on symptom improvement in patients with cervicogenic headache （CGH）.MethodsA total of 84 patients with CGH， diagnosed at the Department Ⅱ of Spine， Wangjing Hospital， China Academy of Chinese Medical Sciences from January 2022 to August 2024， were enrolled and randomly divided into the acupuncture group and the combination group， with 42 patients in each. The acupuncture group received acupuncture alone， while the combination group received rotational-traction manipulation combined with acupuncture. Interventions were performed twice weekly for 4 weeks. Headache frequency， Visual Analog Scale （VAS） scores for neck， occipital， and/or head pain， and cervical range of motion （ROM） scores were evaluated before and after treatment.ResultsAt 2 and 4 weeks post-treatment， headache frequency in both groups decreased significantly compared with baseline （P<0.05）， and the combination group had lower headache frequency than the acupuncture group （P<0.05）. VAS scores at immediate post-treatment， 2 weeks， and 4 weeks were significantly reduced in both groups compared with baseline （P<0.05）， with the combination group showing lower scores than the acupuncture group （P<0.05）. ROM scores at immediate post-treatment， 2 weeks， and 4 weeks differed significantly between the two groups （P<0.05）， with the combination group showing lower ROM scores than the acupuncture group （P<0.05）.ConclusionRotational-traction manipulation combined with acupuncture can effectively reduce headache frequency and pain severity and improve cervical ROM in patients with CGH， demonstrating superior efficacy compared with acupuncture alone.关键词：rotational-traction manipulation;acupuncture;cervicogenic headache2|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo investigate the effects of Lidan Xiaoshi Mixture on the intestinal microbiota of guinea pigs with cholelithiasis using 16S rDNA sequencing technology.MethodsGuinea pigs were randomly assigned by random number table method into six groups： control group （CG，n=10）， model group （MG，n=15）， Danning Tablets group （DN，n=15）， low-dose Lidan Xiaoshi Mixture group （ZD，n=15）， medium-dose Lidan Xiaoshi Mixture group （ZZ，n=15）， and high-dose Lidan Xiaoshi Mixture group （ZG，n=15）. Except for CG， the other groups were subjected to biliary tract intubation and injection of biliary bacterial culture solution from patients with recurrent common bile duct stones to establish a recurrent biliary calculi model. On the day following model establishment， the DN group received Danning Tablets at 0.05 g/（100 g·d） by gavage， while the ZD， ZZ， and ZG groups received Lidan Xiaoshi Mixture at 0.16， 0.32， and 0.64 g/（100 g·d）， respectively. CG and MG received equal volumes of distilled water. All treatments were administered for 7 days. The intestinal microbiota composition of each group was analyzed using 16S rDNA sequencing， and changes in microbial composition and abundance were evaluated.ResultsThe modeling procedure significantly altered the intestinal microbiota composition， with the MG group showing statistically significant differences in species composition compared with other groups （P<0.05）. Intervention with Lidan Xiaoshi Mixture restored the species composition disrupted by modeling. At the genus level， 12 bacterial genera showed significant differences in community abundance among the six groups （P<0.05）.ConclusionLidan Xiaoshi Mixture may modulate the structural composition of the intestinal microbiota， influencing the balance of the "bile acid-intestinal microbiota" axis and the enterohepatic circulation of bile acids， thereby affecting the recurrence of common bile duct stones.关键词：common bile duct stones;Lidan Xiaoshi Mixture;16S rDNA sequencing;Intestinal microbiota;Guinea pig model0|0|0更新时间：2025-12-15
- 摘要：ObjectiveTo investigate the inhibitory effects and underlying mechanisms of the Chinese medicinal material Veronica linariifolia （Lemahui， LMH） on methicillin-resistant Staphylococcus aureus （MRSA） drug-resistant biofilms.MethodsMRSA was cultured to form mature drug-resistant biofilms， which were then treated with LMH injection. The ultrastructure of the biofilms was observed using scanning electron microscopy （SEM）. Based on literature review and database retrieval， the main active components of LMH and genes associated with biofilm drug resistance were identified. The 3D structures of the active compounds and the corresponding biofilm drug-resistance targets were obtained from the SwissTargetPrediction and UniProt databases. Cytoscape software was used to construct the component-target interaction network of LMH. A protein-protein interaction （PPI） network was established using the STRING database. Molecular docking between key active compounds and core targets was performed using AutoDock Vina， followed by 100 ns molecular dynamics （MD） simulations with Gromacs 2022 to screen effective components and genes. Finally， reverse transcription quantitative polymerase chain reaction （RT-qPCR） was used to validate the effects of LMH and its major active components on the expression of core genes related to biofilm formation and drug resistance.ResultsLMH inhibited MRSA biofilm formation. Its main constituents， protocatechuic acid （PCA） and salicylic acid （SA）， bound tightly to the core targets of MRSA drug-resistant biofilms SarA， SarX， Rot， and SigB， with binding energies below -4.5 kcal/mol. Molecular dynamics simulations indicated overall structural stability of these complexes. RT-qPCR showed that LMH significantly downregulated the expression of these core regulatory genes.ConclusionLMH inhibits the formation of MRSA drug-resistant biofilms. Its mechanisms may involve multi-target synergistic modulation by PCA and SA， which interfere with biofilm-associated regulatory networks and downregulate the expression of key regulatory genes.关键词：Veronica linariifolia;methicillin-resistant Staphylococcus aureus;drug-resistant biofilm;network pharmacology;molecular dynamics1|0|0更新时间：2025-12-15
- 摘要：Allergic rhinitis is a common clinical disease that frequently occurs during the spring and autumn allergy seasons. Sphenopalatine ganglion acupuncture is an effective treatment for allergic rhinitis. However， it is technically difficult， carries high risk， and some practitioners use non-standardized techniques， further increasing the risk. The Otolaryngology Professional Committee of the Beijing Association of Chinese Medicine organized relevant experts in China to develop this consensus， based on literature and clinical experience in China and abroad. The consensus aims to standardize the diagnosis and treatment process of sphenopalatine ganglion acupuncture for allergic rhinitis， provide clinicians with scientific and practical guidance， improve therapeutic outcomes， reduce risks， and promote the broader adoption of this technique.关键词：sphenopalatine ganglion;acupuncture technique;Allergic rhinitis;expert consensus2|0|0更新时间：2025-12-15
- 摘要：Psoriasis is a common immune-mediated systemic skin disease that is prone to frequent relapse and has a lingering course， causing great distress to patients' physical and mental health. Professor BAI Yanping， a scholar of traditional Chinese medicine （TCM）， approaches psoriasis from the perspective of integrated TCM and Western medicine， combining internal and external therapies and applying classic formulas in a systematic manner， achieving notable clinical effectiveness. This provides a new direction for the treatment of psoriasis.关键词：Psoriasis;integrated traditional Chinese and western medicine;external treatment;classic formulas;BAI Yanping;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：Prurigo nodularis is a psychogenic disease characterized by itching and nodules as its main clinical manifestations. Professor XU Xian explores its etiology， pathogenesis， and diagnostic and therapeutic approaches from the perspective of the theory of Yinyang stagnation. He holds that when itching is more severe， the disorder lies in yang. Specifically， qi stagnation arises first， and stagnation leads to knotting， generating dampness and blood stasis， which constitutes yin stagnation within yang. When nodules are more prominent， the disorder lies in yin. Specifically， dampness and blood stasis congeal and bind， and knotting gives rise to stagnation， which further leads to qi disorder， representing yang stagnation within yin. "Yinyang stagnation， stagnation causing knotting， and knotting causing further stagnation" is the key to the lingering， recurrent nature of the disease. On this basis， the therapeutic principle of "promoting qi to relieve stagnation and regulating the blood to disperse nodules" is proposed， with the goals of alleviating itching and eliminating nodules. At the initial stage of nodule formation， promoting qi to relieve stagnation prevents the progression toward phlegm and blood stasis. When nodules become stubborn and indurated， regulating the blood to disperse nodules prevents qi disorder， allowing stagnation to be relieved and knots to be dispersed， thereby achieving harmony between qi and blood and mutual integration of yin and yang.关键词：Yinyang;dissipate depression;disperse nodules;prurigo nodularis;XU Xian;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：Professor WEI Zixiao believes that endocrine psychosomatic diseases are closely related to the heart， liver， spleen， and kidney. The basic pathogenesis includes liver depression and qi stagnation， leading to dysfunction of the vital spirit； internal generation of phlegm-heat， which disturbs the vital spirit； and disconnection between the heart and kidney， resulting in a restless mind that fails to settle. In clinical practice， he is skilled in using methods to tranquilize and stabilize the mind， often applying classical formulas such as Xiaoyao Powder， Huanglian Wendan Decoction， and Huanglian Ejiao Decoction， while also preparing his own medicinal formulas for tranquilizing and stabilizing the mind. He emphasizes intervening in the underlying disease mechanisms and， combined with psychological guidance to harmonize the mind and body and improve emotional states， achieves favorable clinical outcomes in the treatment of endocrine metabolic diseases.关键词：endocrine psychosomatic diseases;emotional disorder;tranquilizing and stabilizing mind;WEI Zixiao;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：Professor LIU Qingquan believes that nodular diseases are primarily characterized by "static accumulation"， and are further compounded by qi stagnation and phlegm coagulation. Their key pathogenesis lies in prolonged illness transforming into heat and subsequently generating blood stasis. Qianjin Weijing Decoction is effective in clearing heat， resolving stasis， and dispersing nodules for the treatment of Shangjiao stasis-heat syndrome. Through appropriate modifications， it can be used to treat pulmonary nodules， breast nodules， thyroid nodules， and other related conditions. In clinical practice， Professor LIU accurately determines the stage of the disease and employs Qianjin Weijing Decoction in combination with Chaihu Shugan Powder， Erchen Pingwei Powder， Dachaihu Decoction， Liujunzi Decoction， or Yanghe Decoction， with further modifications as needed. He also carefully selects the dosage and proportional compatibility of Coicis Semen and Persicae Semen within the formula.关键词：pulmonary nodules;breast nodules;thyroid nodules;Qianjin Weijing Decoction;LIU Qingquan;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：The harmonizing method is one of the important therapeutic principles in traditional Chinese medicine （TCM）. It refers to the use of principles such as harmony or reconciliation to achieve the neutralization of yin and yang. The spleen and stomach， located in the middle energizer， are the sources of qi and blood transformation and the key hub for the movement of qi in the body. Professor WANG Shouchuan believes that the clinical incidence of spleen and stomach diseases in children is high， with diverse pathogenesis， commonly involving disharmony among the Zangfu organs， mixed deficiency and excess， a combination of cold and heat， or imbalances between nutrient and defense aspects. The harmonizing method plays a significant role in the treatment of spleen and stomach diseases in children. In clinical practice， it is essential to apply methods such as harmonizing the spleen and stomach， regulating cold and heat， inhibiting the liver and strengthening the spleen， and harmonizing nutrient and defense aspects， along with their variations.关键词：harmonizing therapy;spleen and stomach diseases in children;WANG Shouchuan;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：Professor LIANG Zhiqi differentiates and treats advanced menstruation by focusing on the connections between the Zangfu organs and the extraordinary meridians， classifying the condition into excess and deficiency syndromes. The excess syndromes are mostly caused by the invasion of external heat pathogens， which disturb the thoroughfare vessels and conception vessels and force the blood to flow downward prematurely. The deficiency syndromes are further divided into yin deficiency with internal heat disturbing the blood collaterals， and spleen-kidney deficiency with instability of the belt vessels. In response to the different etiologies and pathogeneses of advanced menstruation， Professor LIANG advocates treating both the root and the symptoms， proposing clearing heat to calm thoroughfare vessels， nourishing yin and blood， tonifying the spleen and kidney， and strengthening the extraordinary meridians as the main therapeutic principles. For cases of long-standing advanced menstruation or those accompanied by heavy bleeding， different charcoal-processed drugs are selected as needed to achieve hemostasis and delay the menstrual period. In Professor LIANG's approach， "nourishing blood" runs through the treatment of all syndromes， with Siwu Decoction as the primary formula. The selective use of various charcoal-processed drugs reflects the principle of treating both the root cause and the symptoms.关键词：advanced menstruation;syndrome differentiation based on Zangfu organs;syndrome differentiation of extraordinary meridians;treating both root cause and symptoms;LIANG Zhiqi;experience of famous doctors2|0|0更新时间：2025-12-15
- 摘要：Abdominal pain， categorized as "pain in the abdomen " in traditional Chinese medicine （TCM）， is one of the common symptoms of pancreatic cancer and severely reduces patients' quality of life， with conventional analgesics often showing limited efficacy. TCM has significant advantages in alleviating cancer-related abdominal pain in pancreatic cancer. Spleen stagnation leading to an inverse disruption of qi is the pathological basis of pancreatic cancer-related abdominal pain. Drawing on exuberance and decline of Wuyun in Huangdi Neijing and its concept of seeking balance through qi transformation， spleen qi stagnation is recognized as the core pathogenesis. The advocated treatment strategy is "adjusting qi and regulating movement"， which involves invigorating qi， restoring vitality， regulating qi and relieving depression， unblocking qi， resolving accumulation， and eliminating residual toxins. This approach provides new diagnostic and therapeutic insights for TCM interventions in pancreatic cancer-related abdominal pain.关键词：Huangdi Neijing;exuberance and decline of Wuyun;pancreatic cancer;abdominal pain;qi regulation2|0|0更新时间：2025-12-15
- 摘要：Aplastic anemia （AA） is a bone marrow hematopoietic failure disease with a complex pathogenesis， mainly involving hematopoietic stem cells， the bone marrow hematopoietic microenvironment， and immune factors. Traditional Chinese medicine （TCM） shows significant advantages in treating this disease. Most practitioners consider kidney essence deficiency as the fundamental pathological basis throughout the disease course， with treatment primarily focused on tonifying the kidney and nourishing marrow. Professor XU Ruirong believes the key pathogenesis lies in marrow depletion with toxin accumulation， as internal accumulation of pathogenic toxins can also damage the bone marrow. Treatment should be based on tonifying the kidney as the root， clearing toxins as the secondary approach， and supplemented by resolving stasis. Guided by the principle of nourishing marrow and removing toxin， TCM decoctions are often combined with herbal ointments. Decoctions act quickly and allow flexible modification， while ointments focus on tonifying deficiency and regulating the body. The combination of both therapies is complementary and enhances overall therapeutic efficacy.关键词：Aplastic anemia;syndrome differentiation and treatment;marrow depletion with toxin accumulation;tonifying the kidney and nourishing marrow;clearing heat and removing toxin2|0|0更新时间：2025-12-15
- 摘要：Chuangzhen is the collective term for infectious exanthematous skin diseases. QIAN Yi believed that the etiology of Chuangzhen lies in the internal accumulation of toxins and external exposure to wind and cold. Before the eruption of Chuangzhen， signs corresponding to the Wuzang organs can be observed； after eruption， each zang organ manifests a distinct symptom， specifically， blisters for the liver， pustules for the lung， spots for the heart， rashes for the spleen， and darkening for the kidney. Based on this， he proposed differentiating and treating Chuangzhen according to Wuzang organs. QIAN Yi advocated differentiating Chuangzhen and typhoid fever from the perspective of the five elements' generation， restraint， and transformation， emphasizing assessment of severity and order of progression. In treatment， both warm- and cool-natured drugs were used. He established three therapeutic methods： dispersion to promote eruption of Chuangzhen， "relief" to clear heat and remove toxin， and "purgation" to promote urination. He emphasized careful application， avoiding indiscriminate dispersion or purgation， while also paying attention to prognosis， preventing complications， and protecting the spleen and kidneys. QIAN Yi's academic thought on differentiation and treatment of Chuangzhen based on Wuzang organs had a significant impact on later generations of physicians and continues to provide a valuable reference for the diagnosis and treatment of infectious skin diseases today.关键词：Chuangzhen;infectious skin diseases;differentiation and treatment from Wuzang organs;QIAN Yi;Key to Medicines and Patterns of Children's Diseases0|0|0更新时间：2025-12-15
- 摘要：Gastroesophageal reflux disease （GERD） is a digestive disorder in which the contents of the stomach and duodenum reflux into the esophagus， causing acid reflux and heartburn as the main clinical manifestations. In traditional Chinese medicine （TCM）， the occurrence and development of GERD are closely related to dysfunction of the Shaoyang pivot. The Shaoyang meridian， located between the half-exterior and half-interior， serves as the pivotal point for the rise and fall of qi in the human body. Dysfunction of the Shaoyang pivot can lead to qi imbalance， generation of internal dampness and turbidity， and hyperactivity of the ministerial fire， resulting in reflux and related symptoms. Based on the theory of "Shaoyang as the pivot"， this study proposes the treatment strategy of regulating the Shaoyang pivot， applying principles of regulating qi， eliminating dampness and turbidity， and clearing and descending ministerial fire. Representative formulas such as Xiaochaihu Decoction， Haoqin Qingdan Decoction， and Dachaihu Decoction are modified according to symptoms， achieving significant therapeutic effects.关键词：Gastroesophageal reflux disease;Shaoyang as the pivot;harmonizing Shaoyang;traditional Chinese medicine treatment2|0|0更新时间：2025-12-15
- 摘要：Immunoglobulin A （IgA） nephropathy is a primary glomerular disease characterized by predominant IgA or IgA deposition in the mesangial region of the glomerulus. The currently widely recognized "multiple-hits" theory of pathogenesis corresponds with the traditional Chinese medicine （TCM） concept of "latent pathogen in the pleurodiaphragmatic interspace". Patients often have congenital deficiency and mucosal immune defects of the Sanjiao. Latent pathogenic factors of wind， dampness， and heat reside in the pleurodiaphragmatic interspace of the Sanjiao and kidney， resulting in impaired permeability of the interspace， disrupted qi transformation of the Zangfu organs， and disharmony of the Sanjiao， ultimately driving the onset of IgA nephropathy. Treatment should follow the principles of eliminating latent pathogens， regulating the Sanjiao， and restoring permeability of the interspace. During the acute stage， therapy focuses on dispersing the latent pathogens causing stagnation in the Sanjiao. In the chronic persistent stage， the approach emphasizes strengthening healthy qi while also addressing residual pathogens， with attention to the effects of proteinuria on syndromes. In the stage of renal function decline， treatment centers on reinforcing healthy qi， tonifying the kidney， combined with removing blood stasis and eliminating turbidity. Therapy should be guided by disease stage and syndrome differentiation， with the goals of dispersing latent pathogens， restoring interspace permeability， harmonizing the Sanjiao， recovering kidney qi transformation， and slowing disease progression.关键词：IgA nephropathy;latent pathogens;pleurodiaphragmatic interspace;Sanjiao;syndrome differentiation and treatment2|0|0更新时间：2025-12-15
- 摘要：Lung nodules are a common clinical condition with a complex pathogenesis and may develop into cancer over time. In the clinical diagnosis and treatment of lung nodules， the "three-in-one" model of differentiating constitution-disease-syndrome can be applied. Constitution differentiation addresses the root cause and prevents disease before its onset： for qi deficiency constitution， treatment focuses on tonifying the lung and boosting qi to prevent retention； for yang deficiency constitution， treatment aims to warm yang and supplement qi to prevent cold-induced coagulation； for qi depression constitution， treatment emphasizes regulating qi and relieving depression to prevent stagnation. Disease and syndrome differentiation guide treatment according to stage and symptoms to prevent disease progression： in the nodule formation stage with phlegm and blood stasis intermingling， treatment focuses on dissolving phlegm and removing blood stasis to eliminate masses； in the nodule canceration stage with emerging cancer toxins， therapy targets toxins and disperses nodules to eliminate cysts； in the post-operative stage with weakened vital qi， treatment emphasizes harmonizing yin and yang and supporting vital qi. The integration of these three differentiations embodies the traditional Chinese medicine （TCM） concept of "preventive treatment of disease"， clarifies the pathogenesis underlying the dynamic changes of lung nodules， and guides stage- and symptom-specific interventions， providing a reference for the prevention and management of lung nodules with TCM in clinical practice.关键词：lung nodule;constitution differentiation;disease differentiation;syndrome differentiation2|0|0更新时间：2025-12-15
- 摘要：The concept of "caused by additions" refers to the combined effect of pre-existing pathogenic factors and new infections that lead to disease. Subsequent generations of physicians expanded this idea to include theories such as combined pathogenic factors， latent pathogenic factors， and multiple causes of disease， emphasizing a holistic and dynamic view of the onset of illness. The pathogenesis of idiopathic membranous nephropathy （IMN） remains incompletely understood， but it is closely related to factors such as genetic predisposition and environmental influences. External infections often worsen or trigger relapses of the condition， which aligns with the essence of "caused by additions"， emphasizing the accumulation of multiple factors leading to disease. Based on the "caused by additions" theory， the pathogenesis of IMN involves two main aspects： deficiency of healthy qi and excess of pathogenic factors， often resulting from a combination of multiple pathogenic factors. Treatment focuses on dispersing external wind and relieving internal wind， strengthening the spleen and tonifying the kidneys to support healthy qi and reinforce vitality， activating blood circulation and resolving stasis， eliminating dampness and removing toxins， and clearing heat and soothing the throat.关键词：idiopathic membranous nephropathy;caused by additions;syndrome differentiation and treatment in TCM0|0|0更新时间：2025-12-15
- 摘要：Knee osteoarthritis （KOA） is classified as a "yin disease". Massage along the large intestine meridian of hand Yangming can "nourish yang" and effectively treat KOA. Its therapeutic mechanisms include strengthening the spleen to generate qi， blood， and body fluids and to fortify muscles； regulating liver qi to promote the circulation of qi， blood， and body fluids and nourish tendons and sinews； and unblocking the brain and regulating the mind to benefit the limbs. For KOA with cold-dampness obstruction syndrome， Erjian （LI 2） and Sanjian （LI 3） are selected； for qi stagnation and blood stasis syndrome， Shousanli （LI 10） and Hegu （LI 4） are chosen； for qi and blood deficiency syndrome，Quchi （LI 11） and Shousanli （LI 10） are applied； and for liver and kidney deficiency syndrome， Hegu （LI 4） and Shousanli （LI 10） are used.关键词：treating yang for yin diseases;massage;large intestine meridian of hand Yangming;knee osteoarthritis2|0|0更新时间：2025-12-15
- 摘要：Traditional therapies in China are recommended for osteoarthritis in guidelines in both China and abroad， yet their clinical application remains limited. This paper analyzes the current clinical status of TCM treatment for osteoarthritis and the treatment selection behaviors of physicians and patients， and reviews the existing research limitations， appropriate guiding theories， and their application in the field of TCM. Future studies， guided by behavioral theory， can explore the choices and influencing factors of TCM treatment among both physicians and patients， with particular emphasis on physicians. This is intended to promote the application of TCM therapies in osteoarthritis， providing practical guidance for the formulation of future TCM health policies and clinical practice.关键词：osteoarthritis;treatment choices;behavioral theory;traditional Chinese medicine;clinical practice2|0|0更新时间：2025-12-15
- 摘要：Corydalis yanhusuo is warm in nature， with a pungent and bitter taste， and enters the hand and foot Taiyin and Jueyin meridians. It is commonly used clinically to regulate qi， activate blood circulation， and relieve pain. Modern pharmacological studies have confirmed that the total alkaloids and organic acids in C. yanhusuo exert significant anti-atherosclerotic effects through anti-inflammatory， analgesic， and lipid-lowering pathways， and these effects are enhanced after processing.关键词：Corydalis yanhusuo;Xuanhu;total alkaloids of Corydalis yanhusuo;atherosclerosis2|0|0更新时间：2025-12-15
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