Objective To study the anti-tumor effects of different dosage ratio between Astragali Radix and Curcumae and difference in mechanism of antitumor angiogenesis. Methods C57BL/6 mice with Lewis lung cancer were established by injecting tumor cells subcutaneously and then randomly divided into model group,cisplatin （DDP） group,and four proportion groups with Astragali Radix and Curcumae Rhizoma in ratio of 0∶1,1∶1,2∶1,and 3∶1 respectively. All groups were given intragastric administration with different drugs or normal saline （NS） for 15 days and then intraperitoneally injected with cisplatin or NS at day 1,3,5,7,9,11,13 and 15. At day 16,after the mice were put to death,the tumor tissue was dissected,tumor weight index and tumor inhibition rate were measured. H-E staining was used to analyze histopathological changes of tumor tissues,Western blot to confirm the protein expression of TGF-β1 and HIF-1α. Results Compared with the model group,tumor weight,tumor weight index and the number of lung surface metastases of different groups of Curcumae Rhizoma and with different proportion of Astragali Radix were much lowered （P < 0. 05）. The groups of tumor inhibition rates with different proportion of Astragali Radix and Curcumae Rhizoma at 0∶1,1∶1,2∶1 and 3∶1 were 21. 91%,23. 89%,37. 70% and 43. 22% respectively. The tumor weight of herbal medicine groups was heavier than that of cisplatin group （P < 0. 05）,but the difference of tumor weight had no statistical significance between 3∶1,2∶1 proportion groups and cisplatin group （P > 0. 05）,and the inhibitory effect of 3∶1 group on tumor weight was better than that of other proportion groups （P < 0. 05）. Compared with the model group,TGF-β1 protein expression of 3∶1 and 2∶1 groups were significantly decreased （P < 0. 01）,and the difference was not statistically significant （P > 0. 05）; compared with the model group,HIF-1α protein expressions in all proportion groups were significantly decreased （P < 0. 01）,3∶1 proportion group was the most similarly decreased with cisplatin group,and lower than that of other proportion groups （P < 0. 01）. Conclusion The high proportion of Astragali Radix has more significantly effects on anti-tumor and anti-metastasis of Curcumae Rhizoma. The mechanism may be related to Astragali Radix’s action of enhancing the inhibition of protein expression of TGF-β1 and HIF-1α of Curcumae Rhizoma.