Objective To analyze TCM syndrome characteristics of 61 patients with acute exacerbation of diffuse parenchymal lung diseases（AE-DPLD）.Methods From January 2013 to May 2017,the characteristics of TCM syndromes and the correlation between TCM syndromes and the clinical features of western medicine in 61 hospitalized patients with AE-DPLD in our hospital were analyzed. Results The first five types of TCM syndromes with higher proportion were: spleen-lung qi deficiency syndrome,interior obstruction of phlegm-damp syndrome,Qi-Yin deficiency syndrome,interior obstruction of dampness-heat syndrome,middle Qi collapse syndrome,cold syndrome and deficiency syndrome occupied the highest proportion,the disease location in lung and spleen were higher. 60 cases were treated with internally taking Chinese herbal medicine with a total of 38 prescriptions involved. Tonifying Qi and nourishing Yin,warming yang and drying dampness were mostly used. Among those with fever,deficiency of qi and yin were seen most. Heat syndrome and exterior syndrome were most found in OP patient in image more than that in UIP an NSIP patient. Among the patients with hypoxemia,spleen-lung qi deficiency syndrome were most found. Kidney was most involved among the patients with use of mechanical ventilation more than without use of mechanical ventilation. Prognosis was poorer in deficiency syndrome. Conclusion Qi deficiency and phlegm-damp syndrome are dominant pathogenic manifestation among 61 cases of AE-DPLD.Lung and spleen are major disease locations.The mainly therapeutic methods are tonifying Qi nourishing Yin,and warming yang and dry dampness.