Objective To study the effects of Huanpifang I on glucose and lipid metabolism in STZ-induced diabetic rats and the study on the mechanism.Methods 60 male SD rats were randomly divided into 6 groups of 10 rats in each group,including blank group,model group,pioglitazone group,low dose group,middle dose group and high dose of Huanpifang I group. Except the blank group,other groups were fed with high glucose and high fat diet combined with intraperitoneal injection of STC to establish diabetic rat model.Pioglitazone group was taken Pioglitazone 17.5 mg/（kg·d）,the low-dose,middle-dose and high-dose groups were respectively given Huanpifang 10.3,0.7 and 1.4 g/（kg·d）respectively, while equal volume of normal saline was given once a day in blank group and model group. After 4 weeks,blood samples were taken to detect fasting plasma glucose（FPG）,oral glucose tolerance test（OGTT）,serum free fatty acid（FFA）,total cholesterol（TC）,triglycerides（TG）,and low density lipoprotein cholesterol（LDL）.ELISA was used to detect the activity of SOD and the content of MDA in liver. Liver histopathologic evaluation was performed by hermatoxylin-eosin staining.Results Compared with the model group,the level of OGTT was decreased significantly at fasting 30 minutes,60 minutes and 120 minutes in high dose group（P<0.01,P<0.05）.The level of FFA,TC,TG and LDL was decreased significantly in high dose group and middle dose group（P<0.01,P<0.05）. The activity of SOD was increased,and the content of MDA reduced in all dose groups（P<0.01,P<0.05）. Conclusion Huanpifang I can improve the glyeolipid metabolism disorder in STZ-induced diabetic rats,which maybe due to anti-oxidative stress.