Experimental study of antibacterial test on Reduning combined with other drugs resistant to carbapenem-resistant acinetobacter baumannii in vitro

LIU Jia; TAO Qing-chun

doi:10.16025/j.1674-1307.2019.01.008

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Experimental study of antibacterial test on Reduning combined with other drugs resistant to carbapenem-resistant acinetobacter baumannii in vitro

更新时间：2023-04-10

- Experimental study of antibacterial test on Reduning combined with other drugs resistant to carbapenem-resistant acinetobacter baumannii in vitro
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 1, Pages: 35-37(2019)
- 作者机构：
  
  1. 北京市房山区中医医院检验科
  2. 北京中医药大学第三附属医院检验科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.01.008
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LIU Jia, TAO Qing-chun. Experimental study of antibacterial test on Reduning combined with other drugs resistant to carbapenem-resistant acinetobacter baumannii in vitro. [J]. Beijing Journal of Traditional Chinese Medicine 38(1):35-37(2019)
DOI：

LIU Jia, TAO Qing-chun. Experimental study of antibacterial test on Reduning combined with other drugs resistant to carbapenem-resistant acinetobacter baumannii in vitro. [J]. Beijing Journal of Traditional Chinese Medicine 38(1):35-37(2019) DOI： 10.16025/j.1674-1307.2019.01.008.

摘要

目的研究中药注射液热毒宁对耐碳青霉烯鲍曼不动杆菌（CRAB）体外抑菌作用。方法采用肉汤稀释法,观察热毒宁注射液、热毒宁注射液联合头孢他啶、热毒宁注射液联合亚胺培南西司他丁钠对CRAB的体外抑菌效果。结果热毒宁对CRAB的最低抑菌浓度（MIC）为400μL/mL,热毒宁分别和头孢他啶、亚胺培南西司他丁钠联合作用于CRAB,与各自单独用药相比,其抑菌所需药物的浓度明显降低。结论热毒宁对CRAB有很好的抑制作用,中西药联用有很好的协同作用,既可以减少抗生素的用量,还能帮助临床拓宽耐药菌选择药物的思路。

Abstract

Objective To study the antibacterial effect of Reduning herbal injection in vitro on carbapenem-resistant acinetobacter baumannii-resistant drugs.Methods Using the broth dilution method,Reduning injection,antimicrobial tests in vitro of Reduning injection combined with ceftazidime,Imipenem-Cilastatin sodium hydrate for the carbapenem-resistant acinetobacter baumannii were conducted.Results Reduning MIC for carbapenem-resistant acinetobacter baumannii was400 l/mL,effects of Reduning combined with,Imipenem-Cilastatin sodium hydrate on carbapenem-resistant acinetobacter baumannii greatly were reduced compared with single Reduning or ceftazidime,Imipenem-Cilastatin sodium hydrate. Conclusion Reduning for carbapenem-resistant acinetobacter baumannii has inhibitory effect,the application of traditional Chinese medicine combined with antibiotics have best coordinate effects as they can reduce the mount of antibiotic and also help solve the problem of drug resistant bacteria.

关键词

热毒宁注射液头孢他啶亚胺培南西司他丁钠耐碳青霉烯鲍曼不动杆菌抑菌作用

Keywords

Reduning injectionCeftazidimeImipenem-Cilastatin sodium hydratecarbapenem-resistant acinetobacter baumanniiantibacterial effect

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