Objective To observe the clinical curative effect of modified Guilu Erxian Glue in the treatment of liver cirrhotic hypoproteinemia through the analysis of changes in 60 patients with liver cirrhotic hypoproteinemia before and after taking medicine.Methods 60 patients with confirmed hypoproteinemia of liver cirrhosis from March 2013 to April 2014 without any treatment within one month in outpatient were randomly divided into two groups.The changes,such as ALB,of patients 3 months before and after the treatment were observed.Results The symptoms were improved in both groups,and the experimental group was better than the control group,abdominal distension,loss of appetite and ascites were mainly improved in the control group;while,costal pain,edema and ascites mostly improved in the experimental group.Jaundice and lassitude were not improved in both two groups.There were significant differences before and after ALB treatment,and the treatment group was superior to the control group（P<0.05）.Conclusion Modified Guilu Erxian Glue may have better effects in improving the comprehensive clinical curative effect and the symptoms of cirrhotic hypoproteinemia. Modified Guilu Erxian Glue can not only elevate ALB level but also improve the blood routine examination of patients.