Objective To observe the effect of Qizhu Granules on the expression of vWF and Caveolin-1 in sinusoidal endothelial cells of rats with hepatic fibrosis.Methods 24 Wister rats were randomly divided into normal group,model group,Qizhu Granules group and Compound Biejia Ruangan Tablets group with 6 in each group.Hepatic fibrosis model was established by intraperitoneal injection of 40% carbon tetrachloride（CCl4） dissolved in olive oil in model group,Qizhu Granules group and Compound Biejia Ruangan Tablets group,at the same time,Qizhu Granules was also given at a dosage of 1.25 g/（k·d） in the Qizhu Granules group,and Compound Biejia Ruangan Tablets given at a dosage of 0.625 g/（k·d） though lavage;the model group was given equal volume of intragastric aseptic water.The drugs were given continuously for 4 weeks.The normal group was raised under the same condition without modeling.vWF and Caveolin-1 in the hepatic tissues were tested with immunohistochemical method and Western blot.Results The expressions of vWF and Caveolin-1 in the hepatic sinusoidal endothelial cells were more strongly expressed in the model group compared with the normal group,but they were significantly weaker in the Qizhu Granules group and the Compound Biejia Ruangan Tablets group（P< 0.05）.Conclusion Qizhu Granules can reduce vWF and Caveolin-1 expression.