Qishen Yiqi Dropping Pills for intervening microcirculation disorder in diabetic rats

LIU Hai-dan; WANG Jun; JIN Ming

doi:10.16025/j.1674-1307.2019.03.010

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Qishen Yiqi Dropping Pills for intervening microcirculation disorder in diabetic rats

更新时间：2023-04-10

- Qishen Yiqi Dropping Pills for intervening microcirculation disorder in diabetic rats
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 3, Pages: 234-236(2019)
- 作者机构：
  
  1. 中日友好医院体检中心
  2. 中日友好医院眼科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.03.010
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LIU Hai-dan, WANG Jun, JIN Ming. Qishen Yiqi Dropping Pills for intervening microcirculation disorder in diabetic rats. [J]. Beijing Journal of Traditional Chinese Medicine 38(3):234-236(2019)
DOI：

LIU Hai-dan, WANG Jun, JIN Ming. Qishen Yiqi Dropping Pills for intervening microcirculation disorder in diabetic rats. [J]. Beijing Journal of Traditional Chinese Medicine 38(3):234-236(2019) DOI： 10.16025/j.1674-1307.2019.03.010.

摘要

目的探讨参芪益气滴丸改善糖尿病大鼠微循环障碍的作用机制。方法 STZ腹腔注射建立1型糖尿病大鼠模型,随机分为模型组、治疗组、阳性对照组,并设正常组。治疗组灌服芪参益气药液,对照组灌服羟苯磺酸钙溶液1 g/（kg·d）,实验周期10个月。利用激光多普勒血流灌注成像仪观察糖尿病大鼠耳廓、四肢及虹膜微循环状态。结果模型组耳廓、四肢皮肤及虹膜血管单位面积血流量较正常组和治疗组均明显减低,差异均有统计学意义（P<0.01,P<0.05）,但与阳性对照组差异无统计学意义（P<0.05）。结论芪参益气滴丸可以增加糖尿病大鼠耳廓、四肢及虹膜单位面积血流量,改善末梢循环缺血状态。

Abstract

Objective To examine the action mechanism of Qishen Yiqi Dropping Pills（QYDP） on microcirculation disorder in diabetic rats with laser Doppler blood perfusion imaging techniques.Methods Streptozocin（STZ） intraperitoneal injection was used to establish a model of diabetic rats,then they were randomly divided into model group,treatment group and control group.At the same time,a normal control group was set up.The treatment group was medicated with QYDP（prepared into liquid）,while the control group with calcium dobesilate liquor（1 g/kg per day） both for 10 months.The blood flow of iris vessels,auricle and limb skin was monitored by laser Doppler blood perfusion image after drug intervention.Results The blood circulation in iris vessels,auricle and limb skin in model group were reduced,and compared with the treatment group and control group,the difference was statistically significant（P<0.05,P<0.01）.Conclusion QYDP can facilitate the peripheral microcirculation and promote the amount of blood perfusion per unit area so as to improve the ischemia of peripheral circulation.

关键词

糖尿病芪参益气滴丸激光多普勒血流灌注成像微循环大鼠

Keywords

diabetesQishen Yiqi Dropping Pillslaser doppler blood perfusion imagingmicrocirculationrat

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