Effect of TCM strengthening antipathogenic qi in assistance of Irinotecan chemotherapy on serum CA19-9 and MMP-7 level in advanced stage of colorectal cancer

REN Ming-zhi; JIANG Yuan

doi:10.16025/j.1674-1307.2019.03.024

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Effect of TCM strengthening antipathogenic qi in assistance of Irinotecan chemotherapy on serum CA19-9 and MMP-7 level in advanced stage of colorectal cancer

更新时间：2023-04-10

- Effect of TCM strengthening antipathogenic qi in assistance of Irinotecan chemotherapy on serum CA19-9 and MMP-7 level in advanced stage of colorectal cancer
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 3, Pages: 277-280(2019)
- 作者机构：
  
  1. 大连大学附属新华医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.03.024
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REN Ming-zhi, JIANG Yuan. Effect of TCM strengthening antipathogenic qi in assistance of Irinotecan chemotherapy on serum CA19-9 and MMP-7 level in advanced stage of colorectal cancer. [J]. Beijing Journal of Traditional Chinese Medicine 38(3):277-280(2019)
DOI：

REN Ming-zhi, JIANG Yuan. Effect of TCM strengthening antipathogenic qi in assistance of Irinotecan chemotherapy on serum CA19-9 and MMP-7 level in advanced stage of colorectal cancer. [J]. Beijing Journal of Traditional Chinese Medicine 38(3):277-280(2019) DOI： 10.16025/j.1674-1307.2019.03.024.

摘要

目的观察中医扶正培本辅助伊立替康化疗对晚期结直肠癌患者血清CA19-9及MMP-7水平的影响。方法选取晚期结直肠癌患者80例,随机分为观察组及对照组各40例。对照组采用伊立替康化疗,观察组采用中医扶正培本辅助伊立替康化疗。观察短期疗效,并随访18个月评估远期疗效;比较治疗前后2组患者血清中CA19-9及MMP-7水平变化。结果治疗后观察组短期疗效为75.00%,显著高于对照组的42.50%（χ,2,=21.792,P,<,0.05）;治疗后观察组CA19-9为（11.47±4.39）kU/L,对照组为（22.84±4.39）kU/L,2组比较差异有统计学意义（t=10.313,P,<,0.05）;观察组MMP-7水平为（19.38±4.29）μg/L,对照组为（25.83±5.01）μg/L,2组比较差异有统计学意义（t=5.639,P,<,0.05）;随访18个月,观察组患者生存率显著高于对照组（P,<,0.05）;观察组不良反应总发生率为25.00%,显著低于对照组的70.00%（χ,2,=40.602,P,<,0.05）。结论采用中医扶正培本法辅助伊立替康化疗治疗晚期结直肠癌患者,可有效提高其临床疗效,并降低血清中CA19-9及MMP-7水平。

Abstract

关键词

结直肠癌扶正培本伊立替康化疗CA19-9MMP-7

Keywords

结直肠癌扶正培本伊立替康化疗CA19-9MMP-7

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