The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study

LI Xiao-jiao; Mostafizi Narjes; XU Ke; WANG Yan-ping; HAN Ming; CHEN Yuan-yuan; FANG Ji-liang

doi:10.16025/j.1674-1307.2019.05.003

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The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study

更新时间：2023-04-10

- The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 5, Pages: 413-417(2019)
- 作者机构：
  
  1. 中国中医科学院广安门医院放射科
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.05.003
  CLC：
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LI Xiao-jiao, Mostafizi Narjes, XU Ke, et al. The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study. [J]. Beijing Journal of Traditional Chinese Medicine 38(5):413-417(2019)
DOI：

LI Xiao-jiao, Mostafizi Narjes, XU Ke, et al. The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study. [J]. Beijing Journal of Traditional Chinese Medicine 38(5):413-417(2019) DOI： 10.16025/j.1674-1307.2019.05.003.

摘要

目的运用静息态功能磁共振（rsfMRI）技术,观察针刺风池穴即刻后脑效应,探索其调制视觉中枢的脑功能机制。方法招募11名健康志愿者,均先后接受左侧风池穴手法针刺及表皮触觉对照刺激,以随机数字表法决定受试者接受2种剌激的先后顺序。每次刺激时间为30 s,频率60次/min。刺激前、即刻后均行6 min脑rsfMRI扫描。采用DPABI4.3软件对rsfMRI数据进行统计学分析,包括比率低频振幅（fALFF）、局部一致性（ReHo）、度中心（DC）分析局部脑活动变化;种子点双侧后扣带皮质（PCC）、腹内侧前额叶（VMPFC）分析全脑功能连接,观察针刺风池穴后的即刻脑功能及全脑功能连接的变化。结果与表皮触觉刺激比较,针刺左侧风池穴视觉相关脑区右侧楔叶、楔前叶局部活动增强（体素水平P<0.01,簇水平P<0.05）,双侧种子点PCC与左侧顶下小叶脑功能连接增强,种子点VMPFC与右侧楔前叶脑功能连接降低（体素水平P<0.01,簇水平P<0.05）。结论风池穴可以调节视觉中枢及邻近脑区功能活动,调制默认网络脑功能连接,可能是其治疗眼部疾病等临床适应证的重要脑功能基础。

Abstract

Objective To observe the immediate brain sustained effects of acupuncture at Fēngchí（GB 20）by using resting-state functional magnetic resonance imaging（rsfMRI）technique and explore the brain functional basis of acupuncture at GB20 for regulating visual cortex.Methods 11 healthy subjects randomly received acupuncture or Von Frey filaments（control）at left GB20.The stimulation time was 30 s and the frequency was 60 times/min.fMRI scan was conducted before and immediately after stimulation for 6 min.MATLAB-based DPABI4.3 software was used to analyze rsfMRI data,including fALFF,ReHo,DC for local brain activity changes,as well as the seed point bilateral posterior cingulate cortex（PCC）and the ventral medial prefrontal（VMPFC）for whole brain functional connectivity and observe the immediate brain sustained effect and whole brain functional connectivity after acupuncture at GB20.Results Compared with the tactile stimulation of Von Frey filaments,acupuncture at left GB20 could clearly modulate the right cuneus and right precuneus which involved to the visual function（voxel P value<0.01, cluster P value <0.05）.The FC between PCC and inferior parietal lobule（BA7, 39, 40）were enhanced, and the FC of the VMPFC and the right precuneus（BA7）were decreased（voxel P value<0.01, cluster P value<0.05）.Conclusion Acupuncture at GB20 could modulate the visual center and adjacent brain regions,as well as the default network,which may be an important brain function basis for the treatment of eye diseases.

关键词

针刺表皮触觉剌激风池穴即刻后效应视皮层静息态功能磁共振

Keywords

acupunctureVon Frey filamentsFēngchí（GB 20）immediate sustained effectvisual cortexresting-state functional magnetic resonance imaging（rsfMRI）

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