Study on preparation technology and preliminary pharmacodynamics of Furong spray film

FAN Zheng; RUI Chao-zheng; CHE Xiao-ping

doi:10.16025/j.1674-1307.2019.05.026

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Study on preparation technology and preliminary pharmacodynamics of Furong spray film

更新时间：2023-04-10

- Study on preparation technology and preliminary pharmacodynamics of Furong spray film
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 5, Pages: 508-511(2019)
- 作者机构：
  
  1. 首都医科大学附属北京中医医院临床药学科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.05.026
  CLC：
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FAN Zheng, RUI Chao-zheng, CHE Xiao-ping. Study on preparation technology and preliminary pharmacodynamics of Furong spray film. [J]. Beijing Journal of Traditional Chinese Medicine 38(5):508-511(2019)
DOI：

FAN Zheng, RUI Chao-zheng, CHE Xiao-ping. Study on preparation technology and preliminary pharmacodynamics of Furong spray film. [J]. Beijing Journal of Traditional Chinese Medicine 38(5):508-511(2019) DOI： 10.16025/j.1674-1307.2019.05.026.

摘要

目的对芙蓉喷膜剂制剂工艺和初步药效学进行探讨。方法以小檗碱、黄芩苷为考察指标,设计正交实验,得出处方最佳提取工艺;通过单因素考察设计实验,确定芙蓉喷膜剂的制剂成型工艺;观察芙蓉喷膜剂对大鼠角叉菜所致足跖肿胀的影响,初步评价芙蓉喷膜剂的药效学。结果黄连、黄柏加8倍量70%乙醇提取2次,每次提取时间为1 h;黄芩等药加8倍量70%乙醇提取2次,每次提取时间为2 h。中药浓缩药液加入到聚乙烯醇（规格1 750±50）、甘油、氮酮中,恒温加热使成膜材料溶解,取上清液,加入冰片、羟苯乙酯即得到芙蓉喷膜剂成品。芙蓉喷膜剂对角叉菜所致大鼠足跖肿胀有抑制作用,且与氢化可的松软膏、芙蓉膏比较差异无统计学意义（P>0.05）。结论芙蓉喷膜剂的提取和制剂工艺合理可行,抗炎作用明确。

Abstract

关键词

芙蓉喷膜剂提取工艺制剂工艺药效学

Keywords

芙蓉喷膜剂提取工艺制剂工艺药效学

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