Research on mechanism of Radix Puerariae in treating Parkinson’s Disease based on visual network

QIAO Tian-ci; WU Hong-yun; PENG Wei

doi:10.16025/j.1674-1307.2019.07.003

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Research on mechanism of Radix Puerariae in treating Parkinson’s Disease based on visual network

更新时间：2023-05-12

- Research on mechanism of Radix Puerariae in treating Parkinson’s Disease based on visual network
- Beijing Journal of Traditional Chinese Medicine Vol. 38, Issue 7, Pages: 635-639(2019)
- 作者机构：
  
  1.   山东中医药大学
  2.   山东中医药大学附属医院脑病三科
  3.   山东中医药大学附属医院科技处
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2019.07.003
  CLC：
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QIAO Tian-ci, WU Hong-yun, PENG Wei. Research on mechanism of Radix Puerariae in treating Parkinson’s Disease based on visual network. [J]. Beijing Journal of Traditional Chinese Medicine 38(7):635-639(2019)
DOI：

QIAO Tian-ci, WU Hong-yun, PENG Wei. Research on mechanism of Radix Puerariae in treating Parkinson’s Disease based on visual network. [J]. Beijing Journal of Traditional Chinese Medicine 38(7):635-639(2019) DOI： 10.16025/j.1674-1307.2019.07.003.

摘要

目的采用网络药理学的方法获得并分析葛根治疗帕金森病（PD）有效的分子机制和通路。方法应用TCMSP、TCMID等数据库总结整理葛根的主要成分和有效作用靶点,DisGeNET数据库提取PD疾病的相关靶点基因,应用String数据库和cytoscape软件建立成分-靶点-疾病网络,采用DAVID对核心靶点进行GO富集分析和KEGG通路分析。结果葛根的63种化学成分中,与PD治疗相关的有13种,相关作用靶点有2,4-二烯酰辅酶A还原酶1（DECR1）、B淋巴细胞瘤-2（BCL2）、雌激素受体1（ESR1）等36个;通路主要与磷脂酰肌醇三激酶-丝氨醇/苏氨酸激酶（PI3K-AKT）、细胞凋亡途径、低氧诱导因子-1（HIF-1）和雌激素信号通路等相关。结论葛根中的葛根素、葛根黄酮、芒柄花黄素、滨蒿内酯等有效成分作用于PI3K-AKT途径、细胞凋亡、雌激素信号通路等过程,可能是葛根治疗PD的分子机制和相关通路。

Abstract

Objective To obtain and analyze the molecular mechanism and pathway of Radix Puerariae in the treatment of Parkinson’s Disease（ PD） by network pharmacology. Methods The main components and effective targets of Radix Puerariae（ RP） were summarized by TCMSP,TCMID,and target genes of PD were extracted from DisGeNET. The component-target-disease network was established by using String database and cytoscape software and GO enrichment and KEGG pathway analysis used to explore the possible targets and pathways. Results Of 63 chemical constituents of RP,13 of them were active ingredients related to PD,and 36 targets such as DECR1, BCL2, ESR1 et al. There were PI3 K-Akt signaling pathway, apoptotic pathway, HIF-1 and estrogen signaling pathway, and so on. Conclusion According to network pharmacology, the components（ formononetin, puerarin,scoparone. et al） of Pueraria lobata mainly acts on PI3 K-AKT pathway,apoptosis and estrogen signal pathways to intervene in the process of PD.

关键词

帕金森病葛根网络药理学分子机制细胞通路

Keywords

Parkinson’s diseaseRadix Puerariaenetwork pharmacologymolecular mechanismcell pathway

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