Objective To observe the effects of Guben Zhike Recipe on pulmonary functionand SIgA in mouse model with chronic obstructive pulmonary disease（COPD）. Methods The mice were divided randomly into five groups,that is blank control group,model control group,Guben Zhike Recipe low-dose group,Guben Zhike Recipe medium-dose group,Guben Zhike Recipe high-dose group with 30 mice in each group. Except the blank control group,the other model groups were established by exposure to cigarette smoke in combination with intra-nostrils injection of lipopolysaccharide. On day 141,herbal medicine groups were given Guben Zhike Recipe of crude drugs 0.036 g/mL（low dose）,0.112 g/mL（medium dose） and 0.22 g/mL（high dose） through gastric lavage respectively and the blank control group and model control group were given 0.9% sodium chloride solution through stomach lavage. All groups were intervened for 4 weeks. The general conditions of mice were observed during modelling period,and morphology was observed by HE staining,and the lung function test of mouse was evaluated, the SIgA level in serum,bronchoalveolar lavage fluid（BALF） and intestinal lavage fluid were tested by ELISA. Results The morphological results of COPD mouse model were consistent with the pathological changes of COPD andthe lung function was decreased significantly in model control group,and the lung function of Guben Zhike Recipe treatment groups were improved significantly compared with model control group（P<0.05）,the SIgA levelin serum and intestinal lavage fluid was decreased（P<0.05）,and the SIgA content in the BALF was increased（P<0.05）. Conclusion Guben Zhike Recipe can enhance lung tissue elasticity and lung compliance in CODP mice,improve lung function,increase the SIgA level in BALF,facilitate the immune function of respiratory mucosa,reduce the SIgA secretion in serum and intestinal lavage fluid,and alleviate the degree of systemic inflammatory injury.