Objective To explore the effect of electroacupuncture stimulation combined with percutaneous penetration therapy on chemotherapy-induced nausea and vomiting and its effect on functional living index-emesis after chemotherapy in patients with malignant tumor.Methods Seventy-two patients with malignant tumor received chemotherapy with DDP were randomly divided into experimental group（n=36）and control group（n=36）.The control group were given routine prophylactic antiemetic drugs.The experimental group was treated with electroacupuncture stimulation on Qūchí（曲池LI11）,Nèiguān（内关PC6）,and Zúsānlǐ（足三里ST36）bilaterally and percutaneous penetration therapy（point application）on the basis of control group.The R-INVR scores on the 1 st,2 nd,3 rd day after chemotherapy and FLIE scores on the 1 st and 6 th day after chemotherapy were evaluated.Results 2 cases in the experimental group withdrew their informed consent and 4 cases of shedding cases in control group.Finally,there were 34 cases in the experimental group and 32 cases in the control group,totally 66 cases.There was no significant difference in the general demographic characteristics and clinical baseline data between the two groups（P>0.05）.Comparing the frequency of nausea between the two groups,there was significant difference between the two groups（P<0.05）at day 2（P=0.005）and day 3（P=0.000）.Comparing the duration of nausea between the two groups,there was significant difference between the two groups（P<0.05）at day 3（P =0.000）.Comparing the severity of nausea between the two groups,there was significant difference between the two groups（P<0.05）at day 1（P=0.047）and day 2（P=0.000）and day 3（P= 0.000）.Comparing the frequency of retching,the volume of vomiting and the severity of vomiting between the two groups,there was significant difference between the two groups（P<0.05）at day 3（P=0.000）.Comparing the frequency and severity of retching between the two groups,there was significant difference between the two groups（P<0.05）at day 2（P = 0.002）and day 3（P=0.000）.Comparing the living function index-emesis between the two groups at day 1 an day 6,there was no significant difference at day 1（P=0.618）（P>0.05）and but is significant at day 6（P=0.000）（P<0.05）.Conclusion Electroacupuncture stimulation combined with percutaneous penetration therapy can effectively relieve nausea,vomiting,retching reaction and improve the living function of patients with malignant tumor at the delayed stage after chemotherapy.However,it had no obvious effect on relieving acute nausea,vomiting and retching after chemotherapy,and could not also completely eliminate the negative effects of CINV on the patients.