Discussion on the mechanism of Zuojin Pills in treating reflux esophagitis based on network pharmacology

CAO Yun; CHEN Jian-xin; FU Xin; HUANG Jia-qin; LIN Jia-ying; LI Zhi-hong

doi:10.16025/j.1674-1307.2020.09.021

您当前的位置：

首页 >

文章列表页 >

Discussion on the mechanism of Zuojin Pills in treating reflux esophagitis based on network pharmacology

更新时间：2023-04-11

- Discussion on the mechanism of Zuojin Pills in treating reflux esophagitis based on network pharmacology
- Beijing Journal of Traditional Chinese Medicine Vol. 39, Issue 9, Pages: 975-979(2020)
- 作者机构：
  
  1. 北京中医药大学东直门医院消化科
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2020.09.021
  CLC：
扫描看全文
[1]曹云,陈建新,符欣,黄佳钦,林稼樱,李志红.基于网络药理学探讨左金丸治疗反流性食管炎的作用机制[J].北京中医药,2020,39(09):975-979+1009.

CAO Yun, CHEN Jian-xin, FU Xin, et al. Discussion on the mechanism of Zuojin Pills in treating reflux esophagitis based on network pharmacology. [J]. Beijing Journal of Traditional Chinese Medicine 39(9):975-979(2020)
[1]曹云,陈建新,符欣,黄佳钦,林稼樱,李志红.基于网络药理学探讨左金丸治疗反流性食管炎的作用机制[J].北京中医药,2020,39(09):975-979+1009. DOI： 10.16025/j.1674-1307.2020.09.021.

CAO Yun, CHEN Jian-xin, FU Xin, et al. Discussion on the mechanism of Zuojin Pills in treating reflux esophagitis based on network pharmacology. [J]. Beijing Journal of Traditional Chinese Medicine 39(9):975-979(2020) DOI： 10.16025/j.1674-1307.2020.09.021.

摘要

目的基于网络药理学探讨左金丸治疗反流性食管炎（reflux esophagitis,RE）多成分、多靶点、多通路的作用机制。方法以药物口服生物利用度（OB）和类药性（DL）为标准,借助中药系统药理学平台（TCMSP）、GeneCards和OMIM数据筛选并预测左金丸活性成分及治疗RE的作用靶标。基于Cytoscape 3.7.1软件构建"活性成分-靶标-疾病"复杂网络及拓扑学分析。借助STRING数据库构建靶蛋白相互作用（protein-protein interaction networks,PPI）网络;通过Uniprot数据库获取靶标蛋白的基因名称,利用DAVID在线工具进行潜在基因的基因本体（gene ontology,GO）分析及基因组百科全书（kyoto encyclopedia of genes and gnomes,KEGG）通路富集分析。结果从TCMSP数据库筛选出左金丸的41种活性成分;C-T-D网络中包含30个化合物,102个靶点。PPI网络中包含102个蛋白,涉及JUN、AKT1、IL6、MAPK1、RELA等关键蛋白。GO富集分析得到GO条目143个,以分子功能为主。KEGG通路富集分析得到132条信号通路,涉及PI3K-Akt信号通路、NF-κB信号通路、JAK-STAT信号通路等。结论左金丸主要通过参与调控炎症反应、细胞增殖和凋亡等途径发挥治疗RE的作用。

Abstract

关键词

反流性食管炎网络药理学左金丸作用机制

Keywords

反流性食管炎网络药理学左金丸作用机制

references

Views

203

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on mechanism of drug pair of Rheum Officinale-Peach Kernel in treatment of deep venous thrombosis based on network pharmacology

Study on the mechanism of Hedyotis diffusa-Scutellaria barbata in treating gastric precancerous lesions based on network pharmacology

Study on the molecular mechanism of Zuojin Pill in the treatment of gastroesophageal reflux disease based on network pharmacology

Mechanism of Weisu Granules in the treatment of chronic gastritis based on network pharmacology

Mechanism of Salvia miltiorrhiza in treating liver fibrosis based on network pharmacology

Related Author

No data

Related Institution

山东中医药大学附属医院周围血管病科

山东中医药大学附属医院运动损伤骨科

山东中医药大学

中国中医科学院望京医院脾胃科

北京中医药大学东直门医院脾胃科

⁰