Correlation between yin and yang deficiency syndrome and left heart remodeling in elderly hypertensive patients with left ventricular hypertrophy

DU Bai; SONG Qing-qiao; CHU Yu-guang; WU Hua-qin; WEI Yi; HU Yuan-hui

doi:10.16025/j.1674-1307.2021.02.006

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Correlation between yin and yang deficiency syndrome and left heart remodeling in elderly hypertensive patients with left ventricular hypertrophy

更新时间：2023-04-10

- Correlation between yin and yang deficiency syndrome and left heart remodeling in elderly hypertensive patients with left ventricular hypertrophy
- Beijing Journal of Traditional Chinese Medicine Vol. 40, Issue 2, Pages: 128-131(2021)
- 作者机构：
  
  1. 中国中医科学院广安门医院心内科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2021.02.006
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[1]杜柏,宋庆桥,褚瑜光,吴华芹,魏艺,胡元会.老年高血压左室肥厚患者阴阳亏虚证型与左心重构相关性研究[J].北京中医药,2021,40(02):128-131.

DU Bai, SONG Qing-qiao, CHU Yu-guang, et al. Correlation between yin and yang deficiency syndrome and left heart remodeling in elderly hypertensive patients with left ventricular hypertrophy. [J]. Beijing Journal of Traditional Chinese Medicine 40(2):128-131(2021)
[1]杜柏,宋庆桥,褚瑜光,吴华芹,魏艺,胡元会.老年高血压左室肥厚患者阴阳亏虚证型与左心重构相关性研究[J].北京中医药,2021,40(02):128-131. DOI： 10.16025/j.1674-1307.2021.02.006.

DU Bai, SONG Qing-qiao, CHU Yu-guang, et al. Correlation between yin and yang deficiency syndrome and left heart remodeling in elderly hypertensive patients with left ventricular hypertrophy. [J]. Beijing Journal of Traditional Chinese Medicine 40(2):128-131(2021) DOI： 10.16025/j.1674-1307.2021.02.006.

摘要

目的探讨老年高血压左室肥厚（LVH）患者虚证中医分型与心脏结构、功能及NT-proBNP之间的相关性。方法将118例老年高血压LVH患者按中医辨证分为阴虚组、阳虚组、阴阳两虚组,比较各组心脏超声结构指标（LAD、LVEDD、LVMI）和心功能指标（EF、FS、E/A）以及血NT-proBNP水平。结果心脏超声结构指标:与阴虚组比较,阴阳两虚组和阳虚组LVEDD、LVMI均有上升趋势,差异有统计学意义（P<0.05）;与阴虚组比较,阴阳两虚组LAD有上升趋势,与阳虚组比较,阴阳两虚组LVMI有上升趋势,差异有统计学意义（P<0.05）。心功能指标:与阴虚组比较,阴阳两虚组和阳虚组E/A有下降趋势、NT-proBNP有上升趋势,差异有统计学意义（P<0.05）;与阴虚组比较,阴阳两虚组EF、FS有下降趋势,与阳虚组比较,阴阳两虚组NT-proBNP有上升趋势,差异有统计学意义（P<0.05）。结论对于老年虚证高血压LVH患者,阳虚较单纯阴虚左心室扩张及左室肥厚更显著;左房扩大可能是老年高血压LVH患者心阳受损的心脏结构表现,左室重量指数大小可能提示心阳虚病程的长短;NT-proBNP能够反映心功能的恶化程度,同时间接提示高血压LVH中医病机心阳虚的演变及受损程度。

Abstract

Objective To explore the correlation between TCM classification of deficiency syndrome and cardiac structure, function and blood NT-proBNP in elderly patients with hypertension and left ventricular hypertrophy（LVH）.Methods 118 cases of elderly patients with hypertension LVH were divided into Yin deficiency group, Yang deficiency group and Yin and Yang deficiency group according to TCM syndrome differentiation.The indexes of Cardiac Ultrasonic structure（LAD,LVEDD,LVMI）,cardiac function（EF,FS,E/a）and blood NT proBNP levels in each group were compared.Results Ultrasonic structural index of heart: compared with Yin deficiency group, LVEDD and LVMI of yin and yang deficiency group and yang deficiency group increased, and the difference was statistically significant（P<0.05）; compared with Yin deficiency group, LAD of yin yang deficiency group had upward tendency.Compared with Yang deficiency group, LVMI in the Yin and Yang deficiency group showed an upward trend, and the difference was statistically significant（P<0.05）.Heart function index: compared with Yin deficiency group, E/A of yin and and yang deficiency group and Yang deficiency group decreased, NT proBNP increased, the difference was statistically significant（P<0.05）; compared with Yin deficiency group, and EF/FS of the Yin and Yang deficiency group decreased; compared with Yang deficiency group, NT proBNP of Yin Yang deficiency group increased, and the difference was statistically significant（P<0.05）.Conclusion Left ventricular dilatation and left ventricular hypertrophy are more significant in elderly hypertensive LVH patients with deficiency syndrome than those with Yin deficiency syndrome; left atrial enlargement may suggest an cardiac structural manifestation of heart Yang damage in elderly hypertensive LVH patients, and left ventricular mass index may indicate the duration of heart yang deficiency; NT proBNP can reflect the deterioration of heart function, and indirectly indicate the evolution and damage degree of heart Yang deficiency in TCM pathogenesis of hypertension LVH.

关键词

老年高血压左室肥厚中医证型

Keywords

Senile hypertensionleft ventricular hypertrophyTCM syndrome type

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