Clinical effect of Bushen Tongluo Recipe on rheumatoid arthritis of liver and kidney yin deficiency type and its influence on related cytokines

SHU Bi-ying; CAI Feng

doi:10.16025/j.1674-1307.2021.02.009

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Clinical effect of Bushen Tongluo Recipe on rheumatoid arthritis of liver and kidney yin deficiency type and its influence on related cytokines

更新时间：2023-04-10

- Clinical effect of Bushen Tongluo Recipe on rheumatoid arthritis of liver and kidney yin deficiency type and its influence on related cytokines
- Beijing Journal of Traditional Chinese Medicine Vol. 40, Issue 2, Pages: 140-143(2021)
- 作者机构：
  
  1. 上海中医药大学附属市中医医院检验科
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2021.02.009
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[1]舒碧莹,蔡枫.补肾通络方治疗肝肾阴虚型类风湿关节炎的临床疗效及其对相关细胞因子含量的影响[J].北京中医药,2021,40(02):140-143.

SHU Bi-ying, CAI Feng. Clinical effect of Bushen Tongluo Recipe on rheumatoid arthritis of liver and kidney yin deficiency type and its influence on related cytokines. [J]. Beijing Journal of Traditional Chinese Medicine 40(2):140-143(2021)
[1]舒碧莹,蔡枫.补肾通络方治疗肝肾阴虚型类风湿关节炎的临床疗效及其对相关细胞因子含量的影响[J].北京中医药,2021,40(02):140-143. DOI： 10.16025/j.1674-1307.2021.02.009.

SHU Bi-ying, CAI Feng. Clinical effect of Bushen Tongluo Recipe on rheumatoid arthritis of liver and kidney yin deficiency type and its influence on related cytokines. [J]. Beijing Journal of Traditional Chinese Medicine 40(2):140-143(2021) DOI： 10.16025/j.1674-1307.2021.02.009.

摘要

目的观察补肾通络方联合甲氨蝶呤治疗肝肾阴虚型类风湿关节炎（RA）临床疗效及对血清细胞因子的影响。方法 64例肝肾阴虚型RA患者,随机分为观察组和对照组,各32例;实际完成61例,观察组31例,对照组30例。2组均给予甲氨蝶呤基础治疗,观察组加用补肾通络方,2次/d, 1袋/次,疗程均为12周。疗程结束后观察2组患者临床疗效,血清细胞因子IL-1β、IL-2R、IL-6、IL-8、IL-10、TNF-α变化情况。结果观察组临床疗效总有效率为83.87%（26/31）,优于对照组的50.00%（15/30）,差异有统计学意义（P<0.05）;与治疗前比较,治疗后观察组IL-6、TNF-α水平下降（P<0.05）,且优于对照组同期（P<0.05）。结论补肾通络方联合甲氨蝶呤治疗肝肾阴虚型RA临床疗效确切,且能降低细胞因子IL-6、TNF-α水平。

Abstract

Objective To observe the clinical effect of Bushen Tongluo Recipe combined with methotrexate in the treatment of liver-kidney Yin deficiency type of rheumatoid arthritis and the effect on serum cytokines.Methods 64 patients with liver-kidney Yin deficiency type of rheumatoid arthritis were randomly divided into treatment group and control group, each group was 32 cases, but 61 cases actually completed with 31 cases in the treatment group and 30 cases in the control group.Both two groups were given the basic treatment with methotrexate, and the treatment group was added with Bushen Tongluo Recipe, 2 times a day, 1 bag each time.The course of treatment was 12 weeks.After the course of treatment finished, the changes of serum cytokines IL-1β,IL-2 R,IL-6,IL-8,IL-10 and TNF-α in 2 groups were observed.Results The total effective rate was 83.87%（26/31）in the treatment group, better than that in the control group which was 50.00%（15/30）,indicating statistically significant difference（P<0.05）.Compared the same group before and after the treatment, the levels of IL-6 and TNF-α in the treatment group was decreased（P<0.05）,but better than those in the control group in same period（P<0.05）.Conclusion Bushen Tongluo Recipe combined with methotrexate is effective in the treatment of liver-kidney Yin deficiency type of rheumatoid arthritis, and can reduce the levels of cytokines IL-6 and TNF-α.

关键词

类风湿关节炎补肾通络方肝肾阴虚型临床疗效细胞因子

Keywords

rheumatoid arthritisBushen Tongluo Recipeliver-kidney Yin deficiencyclinical efficacycytokines

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