Objective To observe the effect of Qingfei Jiangzhuo Prescription on inflammatory response and organ protection in patients with severe pneumonia of obstruction of phlegm heat in the lung.Methods A total of 68 cases of severe pneumonia with phlegm heat obstructing lung syndrome treated in Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine from September 2017 to September 2019 were randomly divided into combined Chinese and western medicine treatment group and western medicine treatment group with 34 cases in each group.The western medicine group was treated by routine western medicine.On the basis of the routine treatment, the Chinese and western medicine group was also given Qingfei Jiangzhuo Prescription, one bag each day and for 7 days as one course.The clinical efficacy, pneumonia severity index（PSI）,acute physiology and chronic health evaluation Ⅱ（APACHE Ⅱ）,C-reactive protein（CRP）,procalcitonin（PCT）,interleukin-6（IL-6）,oxygenation index（PaO,2,/FiO,2,）,carbon dioxide（PaCO,2,）,systolic blood pressure（SBP）,lactic acid（Lac）,fibrinogen（FBG） and D-Dimer（D-D） were compared between the two groups before and after the treatment.Results The effective rate of the Chinese and western medicine group was higher than that of the western medicine group, but the difference was not statistically significant（P,>,0.05）.The scores of PSI and APACHE Ⅱ in both two groups were significantly lowered than those before the treatment（P,<,0.05）,and the decline in the Chinese and western medicine group was more pronounced than the western medicine（P,<,0.05）.The same change happened with the levels of CRP,PCT,IL-6,Lac in the two groups.After treatment the oxygenation indexes（PaO,2,/FiO,2,） in the two groups were higher than those before treatment; And the change was more obliviously in the Chinese and western medicine group（P,<,0.05）.The levels of SBP and PaCO,2, were normal before and after the treatment.Conclusion Qingfei Jiangzhuo Prescription combined with western medicine can reduce the severity of the disease, and that may be the Results of its reducing inflammatory reaction, improving respiratory and circulatory function capability.