Objective To investigate the clinical effect of modified Zishui Qinggan Decoction combined with Estradiol Tablets/Estradiol and Dydrogesterone Tablets for patients with menopausal syndrome of kidney deficiency and liver stagnation.Methods 80 cases of postmenopausal syndrome with kidney deficiency and liver stagnation were randomly divided into two groups.The control group was treated with Estradiol Tablets/Estradiol Didroxyprogesterone Tablets composite packaging（Femoston）.The observation group was treated with Zishui Qinggan Decoction on the basis of the control group.The treatment lasted for 3 months.The clinical effect, Kupperman score, Menqol score, serum follicle stimulating hormone（FSH）,estrogen（E,2,） levels and adverse reactions were observed before and after the treatment in both two groups.Results After 3 months, the total effective rate of the observation group was significantly higher than that of the control group（P,<,0.05）.The TCM symptom score, Kupperman score, Menqol score, serum FSH and E,2, levels of the observation group were better than those of the control group（P,<,0.05）; the incidence of adverse reactions in the observation group was lower than that in the control group, but the difference was not statistically significant（P,>,0.05）.Conclusion Modified Zishui Qinggan Decoction combined with Fenmatong is more effective than single use of western medicine in the treatment of menopausal syndrome with kidney deficiency and liver stagnation because it can effectively regulate the level of endocrine hormones and improve the quality of life with safety.