Objective To investigate the clinical efficacy of blood heat syndrome of psoriasis vulgaris under the same treatment scheme, and explore the related factors affecting the efficacy.Methods The clinical data of 221 patients with blood heat syndrome of psoriasis vulgaris were retrospectively analyzed.PASI25 was used as the cut-off value of clinical efficacy and inefficacy, of which inefficacy was seen in 52 cases and effectiveness in 169 cases.Statistical analysis of patients with general personal data and differences in the results of the first laboratory examination, the indicators with statistical significance were included in the multivariate logistic regression analysis, and the independent related factors affecting the prognosis were obtained.Results 221 patients received TCM treatment, and the core recipe was Liangxue Jiedu Decoction.The total effective rate was 76.9%.NLR,PLR,CRP,hypoproteinemia, abnormal liver function, previous complex treatment and metabolic diseases were independent risk factors for prognosis.Conclusion The comprehensive treatment of TCM with Liangxue Jiedu Decoction as the core recipe has definite clinical effect.The patients′ previous treatment, whether they are complicated with metabolic diseases, NLR,PLR,CRP,liver function and albumin levels are all helpful to evaluate the prognosis.