ZHENG Ying-ying, TAO Lin. Bayesian network meta-analysis of TCM famous classical formulas for the treatment of gastroesophageal reflux disease. [J]. Beijing Journal of Traditional Chinese Medicine 40(11):1285-1289(2021)
DOI:
ZHENG Ying-ying, TAO Lin. Bayesian network meta-analysis of TCM famous classical formulas for the treatment of gastroesophageal reflux disease. [J]. Beijing Journal of Traditional Chinese Medicine 40(11):1285-1289(2021) DOI: 10.16025/j.1674-1307.2021.11.032.
Bayesian network meta-analysis of TCM famous classical formulas for the treatment of gastroesophageal reflux disease
摘要
目的系统评价6种经典中药方剂单用或联合质子泵抑制剂(PPI)治疗胃食管反流病(GERD)的疗效。方法检索中国知网、万方、维普、中国生物医学数据库、PubMed、Cochrane图书馆、Web of Science、Clinical Trails,收集6种方剂治疗GERD的随机或半随机对照试验。以NoteExpress筛选文献,提取资料后用偏倚风险评估工具RoB-2评价文献质量,并用Stata 15.1和ADDIS 1.16.8进行网状Meta分析。结果纳入49项文献,4786例患者,13种干预措施。网状Meta分析示仅四逆散疗效低于PPI,半夏厚朴汤联合PPI、半夏泻心汤联合PPI疗效最佳;单用旋覆代赭汤、小柴胡汤、柴胡疏肝散疗效较好;半夏泻心汤联合PPI疗效优于半夏泻心汤具统计学意义。结论推荐半夏厚朴汤联合PPI及半夏泻心汤联合PPI治疗GERD。
Abstract
目的系统评价6种经典中药方剂单用或联合质子泵抑制剂(PPI)治疗胃食管反流病(GERD)的疗效。方法检索中国知网、万方、维普、中国生物医学数据库、PubMed、Cochrane图书馆、Web of Science、Clinical Trails,收集6种方剂治疗GERD的随机或半随机对照试验。以NoteExpress筛选文献,提取资料后用偏倚风险评估工具RoB-2评价文献质量,并用Stata 15.1和ADDIS 1.16.8进行网状Meta分析。结果纳入49项文献,4786例患者,13种干预措施。网状Meta分析示仅四逆散疗效低于PPI,半夏厚朴汤联合PPI、半夏泻心汤联合PPI疗效最佳;单用旋覆代赭汤、小柴胡汤、柴胡疏肝散疗效较好;半夏泻心汤联合PPI疗效优于半夏泻心汤具统计学意义。结论推荐半夏厚朴汤联合PPI及半夏泻心汤联合PPI治疗GERD。
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