Clinical effect of Jiawei Hegan Decoction on functional constipation of liver depression and spleen deficiency pattern and its influence on serum intestinal neurotransmitters

Jin-su ZHENG; Hong-xun ZHU; Hong QUAN

doi:10.16025/j.1674-1307.2022.03.021

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Clinical effect of Jiawei Hegan Decoction on functional constipation of liver depression and spleen deficiency pattern and its influence on serum intestinal neurotransmitters

更新时间：2023-02-15

- Clinical effect of Jiawei Hegan Decoction on functional constipation of liver depression and spleen deficiency pattern and its influence on serum intestinal neurotransmitters
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 3, Pages: 309-312(2022)
- 作者机构：
  
  1.首都医科大学附属北京朝阳医院中医科，北京 100020
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.03.021
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郑金粟，朱宏勋，权红.加味和肝汤治疗肝郁脾虚型功能性便秘的临床疗效及对血清肠神经递质的影响［J］.北京中医药，2022，41（3）：309-312.

ZHENG Jin-su,ZHU Hong-xun,QUAN Hong.Clinical effect of Jiawei Hegan Decoction on functional constipation of liver depression and spleen deficiency pattern and its influence on serum intestinal neurotransmitters[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(03):309-312.
郑金粟，朱宏勋，权红.加味和肝汤治疗肝郁脾虚型功能性便秘的临床疗效及对血清肠神经递质的影响［J］.北京中医药，2022，41（3）：309-312. DOI： 10.16025/j.1674-1307.2022.03.021.

ZHENG Jin-su,ZHU Hong-xun,QUAN Hong.Clinical effect of Jiawei Hegan Decoction on functional constipation of liver depression and spleen deficiency pattern and its influence on serum intestinal neurotransmitters[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(03):309-312. DOI： 10.16025/j.1674-1307.2022.03.021.

摘要

目的,2,观察加味和肝汤治疗肝郁脾虚型功能性便秘（FC）的临床疗效及对血清肠神经递质的影响。,方法,2,选取2016年10月—2018年10月首都医科大学附属北京朝阳医院中医科门诊及病房收治的肝郁脾虚型FC患者，采用随机数字表法分为2组。观察组38例，给予加味和肝汤颗粒剂治疗；对照组36例，给予枸橼酸莫沙比利分散片治疗，2组疗程均为4周。对比2组临床疗效，治疗前后血清肠神经递质P物质（SP）、一氧化氮（NO）水平及不良反应发生情况。,结果,2,治疗4周，观察组总有效率高于对照组（,χ,2,=4.252，,P,<,0.05）；2组中医证候评分均较治疗前降低（,P,<,0.05），且观察组中医证候评分低于对照组（,P,<,0.05）；治疗4周2组血清NO、SP水平较治疗前改善（,P,<,0.05），且观察组血清SP水平高于对照组（,P,<,0.05）。2组均未发生不良反应。,结论,2,加味和肝汤治疗肝郁脾虚型FC有效，能明显改善患者便秘临床症状及肝郁脾虚中医证候，调控血清肠神经递质水平，安全性高。

Abstract

关键词

功能性便秘加味和肝汤肝郁脾虚肠神经递质

Keywords

references

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