Effect of added Qishen Taohong Granules on treatment of chronic heart failure

LI Xing-xing; LIN Quan; LU Jin-jin; CUI Xiao-yun; LI Dong; FAN Zong-jing; CUI Jie; WU Yang; LIN Qian; LI Yan

doi:10.16025/j.1674-1307.2022.04.007

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Effect of added Qishen Taohong Granules on treatment of chronic heart failure

更新时间：2023-06-16

- Effect of added Qishen Taohong Granules on treatment of chronic heart failure
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 4, Pages: 374-378(2022)
- 作者机构：
  
  1.北京中医药大学,北京 100029
  2.北京中医药大学东方医院,北京 100078
  3.北京中医药大学东直门医院,北京 100700
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.04.007
  CLC：
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李星星，林泉，逯金金，等.加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察［J］.北京中医药，2022，41（4）：374-378.

LI Xing-xing,LIN Quan,LU Jin-jin,et al.Effect of added Qishen Taohong Granules on treatment of chronic heart failure[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(04):374-378.
李星星，林泉，逯金金，等.加用芪参桃红颗粒对慢性心力衰竭疗效的影响观察［J］.北京中医药，2022，41（4）：374-378. DOI： 10.16025/j.1674-1307.2022.04.007.

LI Xing-xing,LIN Quan,LU Jin-jin,et al.Effect of added Qishen Taohong Granules on treatment of chronic heart failure[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(04):374-378. DOI： 10.16025/j.1674-1307.2022.04.007.

摘要

目的,2,观察加用芪参桃红颗粒对慢性心力衰竭（CHF）患者利尿剂停减率和再住院率的影响。,方法,2,采用前瞻性、随机、对照临床试验方法，将103例CHF患者随机分为观察组和对照组。2组均予西医常规治疗，观察组在此基础上加用芪参桃红颗粒，对照组加用盐酸曲美他嗪，疗程均为4周。评价2组患者治疗前后心功能（NYHA分级）、利尿剂停减率和再住院率的变化，并对芪参桃红颗粒治疗CHF进行安全性评价。,结果,2,治疗4周后，观察组NYHA心功能分级总有效率76.2%、对照组为58.8%，2组间差异有统计学意义（,P<,0.05）；观察组患者的利尿剂停减率为80.00%、对照组52.94%，2组间差异有统计学意义（,P,<,0.05）。入组24周后，观察组和对照组患者再住院率分别为33.33%和46.34%。2组患者在治疗期间均未发生明显不良反应。,结论,2,芪参桃红颗粒可改善CHF患者的心功能，提高利尿剂停减率，降低再住院率。

Abstract

Objective,2,To observe the effect of added Qishen Taohong Granules on treatment of patients with chronic heart failure （CHF）.,Methods,2,Using prospective，randomized，controlled clinical trial methods，103 CHF patients were randomly divided into treatment group and control group. Both groups were treated with conventional western medicine. On this basis，the treatment group was treated with Qishen Taohong Granules and the control group was treated with trimetazidine hydrochloride for 4 weeks. The changes in cardiac function （NYHA classification），diuretic discontinuation rate and rehospitalization rate of the two groups of patients before and after treatment were evaluated，and the safety of Qishen Taohong Granules in the treatment of chronic heart failure was evaluated.,Results,2,After 4 weeks of treatment，the total effective rate of NYHA cardiac function classification in the treatment group was 76.2%，and that of the control group was 58.8%，and the difference of two groups were statistically significant（,P,<,0.05）；the diuretic discontinuation rate of patients in the treatment group was 80.00% and the control group was 52.94 %，there was a statistical difference between the two groups （,P,<,0.05）. After 24 weeks of enrollment，the rehospitalization rate of patients in the treatment group and the control group were 33.33% and 46.34% respectively. There were no obvious adverse events in the two groups during the treatment.,Conclusion,2,Qishen Taohong Granules can improve the cardiac function，increase the diuretic discontinuation rate and reduce the rehospitalization rate of patients with chronic heart failure.

关键词

芪参桃红颗粒慢性心力衰竭利尿剂停减率再住院率

Keywords

Qishen Taohong Granuleschronic heart failurediuretic discontinuation raterehospitalization rate

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