Correlation between bone marrow edema of sacroiliac joint and TCM syndromes in male patients with ankylosing spondylitis

Juan WU; Yue YANG; Yue LI; Shi-qing QU; Zhen-guo HUANG; Ze-ran YAN; Qing-wen TAO; Xiao-ping YAN; Wei-ping KONG

doi:10.16025/j.1674-1307.2022.08.002

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Correlation between bone marrow edema of sacroiliac joint and TCM syndromes in male patients with ankylosing spondylitis

更新时间：2023-02-15

- Correlation between bone marrow edema of sacroiliac joint and TCM syndromes in male patients with ankylosing spondylitis
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 8, Pages: 833-837(2022)
- 作者机构：
  
  1.北京中医药大学研究生院，北京100029
  2.中日友好医院中医风湿病科免疫炎性疾病北京市重点实验室，北京100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.08.002
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吴娟，杨悦，李月，等.男性强直性脊柱炎患者骶髂关节骨髓水肿与中医证候的相关性研究［J］.北京中医药，2022，41（8）：833-837.

WU Juan,YANG Yue,LI Yue,et al.Correlation between bone marrow edema of sacroiliac joint and TCM syndromes in male patients with ankylosing spondylitis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(08):833-837.
吴娟，杨悦，李月，等.男性强直性脊柱炎患者骶髂关节骨髓水肿与中医证候的相关性研究［J］.北京中医药，2022，41（8）：833-837. DOI： 10.16025/j.1674-1307.2022.08.002.

WU Juan,YANG Yue,LI Yue,et al.Correlation between bone marrow edema of sacroiliac joint and TCM syndromes in male patients with ankylosing spondylitis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(08):833-837. DOI： 10.16025/j.1674-1307.2022.08.002.

摘要

目的,2,探讨男性强直性脊柱炎（AS）患者骶髂关节骨髓水肿与中医证候的关系，并分析骶髂关节骨髓水肿的危险因素。,方法,2,收集2017年8月―2021年12月中日友好医院中医风湿病科门诊及住院男性AS患者143例，根据骶髂关节核磁共振成像加拿大脊柱关节病研究协会（SPARCC）评分将患者分为骶髂关节骨髓水肿组（SPARCC评分≥2，骨髓水肿组）和骶髂关节无骨髓水肿组（SPARCC评分<2，无骨髓水肿组），分析2组患者的疾病特征差异，采用logistic回归分析患者骶髂关节骨髓水肿的危险因素。,结果,2,骨髓水肿组男性AS患者肾虚湿热证多见，无骨髓水肿组男性AS患者肾虚督寒证多见；与无骨髓水肿组比较，骨髓水肿组HLA-B27阳性率、ESR及CRP水平升高（,P,<,0.05）。多因素logistic回归分析显示，肾虚湿热证、HLA-B27阳性及ESR是男性AS患者骶髂关节骨髓水肿的危险因素（,P,<,0.05）。,结论,2,骶髂关节骨髓水肿程度较高的男性AS患者更多见肾虚湿热证，肾虚湿热证、HLA-B27阳性和ESR水平是男性AS患者骶髂关节炎症的危险因素。

Abstract

Objective,2,To investigate the relationship between bone marrow edema（BME） on sacroiliac joints（SIJ）and TCM syndromes in male patients with ankylosing spondylitis （AS） and risk factors for BME on SIJ.,Methods,2,143 male AS patients treated in outpatient and inpatient departments of TCM Rheumatology in China-Japan Friendship Hospital from August 2017 to December 2021 were selected and according to the MRI of Sacroiliac Joint Canadian Association for the Study of Spinal Arthritis （SPARCC）， the patients were divided into sacroiliac joint bone marrow edema group （SPARCC score ≥2， bone marrow edema group） and none sacroiliac joint bone marrow edema group （SPARCC score < 2， none bone marrow edema group） to analyze the differences in disease characteristics of two groups of patients with or without BME on SIJ MRI， and the risk factors for BME on SIJ MRI by logistic regression.,Results,2,Kidney deficiency and dampness heat syndrome was more common in male AS patients in bone marrow edema group，and kidney deficiency and cold syndrome in Du meridian in male AS patients in none bone marrow edema group； compared with none bone marrow edema group， the HLA-B27 positivity rate，ESR and CRP levels were significantly higher in bone marrow edema group （,P,<,0.05）. Multivariate logistic regression analysis showed that kidney deficiency and dampness heat syndrome， HLA-B27 positivity and ESR were risk factors for BME on SIJ MRI （SPARCC score ≥2） in male AS patients （,P,<, 0.05）.,Conclusion,2,Severe BME on SIJ in male AS patients is more likely to be associated with kidney deficiency and dampness heat syndrome. Kidney deficiency and dampness heat syndrome，HLA-B27 positivity and ESR level are risk factors for inflammation on SIJ with male AS.

关键词

男性强直性脊柱炎中医证型磁共振成像骨髓水肿

Keywords

Maleankylosing spondylitisTCM syndromemagnetic resonance imagingbone marrow edema

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