Improvement of Qipo Shengmai Granules for atrial fibrosis in rats with atrial fibrillation by regulating PI3K/SGK1 signal pathway

SHI Jing-jing; MENG Hao; SHOU Xin-tian; DUAN Cheng-lin; HU Yuan-hui

doi:10.16025/j.1674-1307.2022.10.002

您当前的位置：

首页 >

文章列表页 >

Improvement of Qipo Shengmai Granules for atrial fibrosis in rats with atrial fibrillation by regulating PI3K/SGK1 signal pathway

更新时间：2023-06-16

- Improvement of Qipo Shengmai Granules for atrial fibrosis in rats with atrial fibrillation by regulating PI3K/SGK1 signal pathway
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 10, Pages: 1079-1083(2022)
- 作者机构：
  
  1.中国中医科学院广安门医院心血管科，北京 100053
  2.首都医科大学附属北京中医医院心血管科，北京 100010
  3.中国中医科学院广安门医院，北京 100053
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.10.002
  CLC：
扫描看全文
石晶晶，孟昊，寿鑫甜，等.芪珀生脉颗粒通过调节PI3K/SGK1信号通路改善心房颤动大鼠心房肌纤维化［J］.北京中医药，2022，41（10）：1079-1083.

SHI Jing-jing,MENG Hao,SHOU Xin-tian,et al.Improvement of Qipo Shengmai Granules for atrial fibrosis in rats with atrial fibrillation by regulating PI3K/SGK1 signal pathway[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1079-1083.
石晶晶，孟昊，寿鑫甜，等.芪珀生脉颗粒通过调节PI3K/SGK1信号通路改善心房颤动大鼠心房肌纤维化［J］.北京中医药，2022，41（10）：1079-1083. DOI： 10.16025/j.1674-1307.2022.10.002.

SHI Jing-jing,MENG Hao,SHOU Xin-tian,et al.Improvement of Qipo Shengmai Granules for atrial fibrosis in rats with atrial fibrillation by regulating PI3K/SGK1 signal pathway[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1079-1083. DOI： 10.16025/j.1674-1307.2022.10.002.

摘要

目的,2,验证芪珀生脉颗粒通过调节PI3K/SGK1信号通路改善心房颤动（简称“房颤”）大鼠心房肌纤维化的机制。,方法,2,采用尾静脉注射乙酰胆碱-氯化钙（Ach-CaCl,2,）建立房颤大鼠模型，随机分为正常对照组、模型组、维拉帕米组、芪珀生脉大剂量组、芪珀生脉中剂量组、芪珀生脉小剂量组，共6组。用药干预4周后，比较各组大鼠房颤持续时间、心房肌组织病理改变，运用Western Blot法检测PI3K/SGK1信号通路蛋白的表达水平。,结果,2,与模型组相比，芪珀生脉颗粒各剂量组大鼠房颤持续时间显著缩短，大鼠心房肌PI3K、CTGF蛋白表达明显下调，SGK1蛋白的磷酸化明显减轻，差异有统计学意义（,P,<, 0.05）。,结论,2,芪珀生脉颗粒可有效改善房颤过程中的心房纤维化、缩短房颤持续时间，其机制可能与其调节PI3K/SGK1信号通路，包括下调PI3K、CTGF蛋白的表达，减少SGK1蛋白的磷酸化有关。

Abstract

关键词

芪珀生脉颗粒心房颤动PI3K/SGK1信号通路心房肌纤维化大鼠

Keywords

references

ALLESSIE M, AUSMA J, SCHOTTEN U. Electrical, contractile and structural remodeling during atrial fibrillation[J]. Cardiovasc Res,2002,54:230-246.

TERADA Y, KUWANA H, KOBAYASHI T, et al. Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium[J]. J Am Soc Nephrol,2008,19(2):298-309.

MARTÍN-FERNÁNDEZ B， VALERO MUÑOZ M， DE LAS HERAS N，et al. Relevance of SGK1 in structural， functional and molecular alterations produced by aldosterone in heart［J］. Horm Mol Biol Clin Investig，2014，18（2）：53-61.

张菀桐, 胡元会, 师帅,等.迷走神经性房颤大鼠模型的建立及心房电生理学研究[J].心脏杂志,2019,31(1):8-11.

石树青, 张菀桐, 李大奇,等. 芪珀生脉颗粒调控线粒体生物合成通路改善房颤大鼠代谢应激的机制研究[J]. 北京中医药,2021,40(6):562-566.

NATTEL S . Molecular and cellular mechanisms of atrialfibrosis in atrialfibrillation[J]. JACC Clin Electrophysiol,2017,3(5):425-435.

MATSUI T, TAO J, MONTE FD, et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo[J]. Circulation,2001,104(3):330-335.

COOK SA, VARELACARVER A, MONGILLO M, et al. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction[J]. Eur Heart J,2010,31(1):100-111.

AOYAMA T, MATSUI T, NOVIKOV M, et al. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophicresponse[J]. Circulation，2005,111:1652-1659.

GAN WQ, LI TG, REN JY, et al. Serum-glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts[J]. Mol Cell Biochem,2018,445(1/2):67-78．

XU SW, LEASK A, ABRAHAM D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis[J]. Cytokine Growth Factor Rev,2008,19(2):133-144.

AHMED MS, ØIE E, VINGE LE, et al. Connective tissue growth factor：a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats[J]. J Mol Cell Cardiol,2004,36(3):393-404.

KO WC, HONG CY, HOU SM, et al. Elevated expression of connective tissue growth factor in human atrial fibrillation and angiotensin II-treated cardiomyocytes[J]. Circ J,2011,75(7):1592-1600.

VALLON V, WYATT AW, KLINGEL K, et al. SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment[J]. J Mol Med (Berl),2006,84(5):396-404.

MARTÍN-FERNÁNDEZ B, DE LAS HERAS N, MIANa M, et al. Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated Kinase-1 expression[J]. J Cardiovasc Pharmacol,2011,57(1):114-121.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Pharmacodynamics and mechanical study of Qibo Shengmai Granules on atrial fibrillation of rats

Mechanism-Syndrome-Treatment of traditional Chinese medicine in co-disease of atrial fibrillation and hyperuricemia

Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism

Effect of Tangbikang on the expression of p-JNK and Bcl-2 in sciatic nerve of diabetes rats

Traditional Chinese medicine treatment of atrial fibrillation: speculation and advantages

Related Author

No data

Related Institution

Cardiovascular Department,Guang’anmen Hospital,China Academy of Chinese Medical Sciences

首都医科大学附属北京友谊医院医务处

首都医科大学中医药学院

Department of Traditional Chinese Medicine， Beijing Friendship Hospital Affiliated to the Capital Medical University

Department of Respiratory and Critical Care Medicine， Weinan Second Hospital

⁰