Clinical observation of Jianpi Lishi Tongluo Decoction in treating type 2 diabetes mellitus with hyperuricemia

XING Jun-yan; MENG Yuan; LI Yi-meng; CUI Jia-lin; WANG Ying-jie; GAO Yan-bin

doi:10.16025/j.1674-1307.2022.10.007

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Clinical observation of Jianpi Lishi Tongluo Decoction in treating type 2 diabetes mellitus with hyperuricemia

更新时间：2023-06-16

- Clinical observation of Jianpi Lishi Tongluo Decoction in treating type 2 diabetes mellitus with hyperuricemia
- Beijing Journal of Traditional Chinese Medicine Vol. 41, Issue 10, Pages: 1110-1114(2022)
- 作者机构：
  
  1.首都医科大学中医药学院，北京 100069
  2.首都医科大学附属北京中医医院肾病科，北京 100010
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2022.10.007
  CLC：
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邢俊艳，孟元，李益萌，等.健脾利湿通络方治疗2型糖尿病合并高尿酸血症临床观察［J］.北京中医药，2022，41（10）：1110-1114.

XING Jun-yan,MENG Yuan,LI Yi-meng,et al.Clinical observation of Jianpi Lishi Tongluo Decoction in treating type 2 diabetes mellitus with hyperuricemia[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1110-1114.
邢俊艳，孟元，李益萌，等.健脾利湿通络方治疗2型糖尿病合并高尿酸血症临床观察［J］.北京中医药，2022，41（10）：1110-1114. DOI： 10.16025/j.1674-1307.2022.10.007.

XING Jun-yan,MENG Yuan,LI Yi-meng,et al.Clinical observation of Jianpi Lishi Tongluo Decoction in treating type 2 diabetes mellitus with hyperuricemia[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1110-1114. DOI： 10.16025/j.1674-1307.2022.10.007.

摘要

目的,2,观察健脾利湿通络方治疗2型糖尿病合并高尿酸血症的临床疗效。,方法,2,选择2020年1月—2021年7月于首都医科大学附属北京中医医院肾病科、内分泌科就诊的2型糖尿病合并高尿酸血症患者72例，根据随机数字表法分为治疗组、对照组各36例。2组均采用糖尿病规范化治疗，治疗组加服健脾利湿通络方，1剂/d，早晚分服；对照组加服苯溴马隆，50 mg/d，1次/d。2组疗程均为8周。对比2组中医证候疗效、尿酸（UA）疗效，比较2组治疗前后中医证候积分及空腹血糖（FBG）、餐后2小时血糖（2 h PBG）、糖化血红蛋白（HbA1C）、UA、一氧化氮（NO）、黄嘌呤氧化酶（XOD）、超敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）水平。,结果,2,治疗组中医证候总有效率高于对照组，差异有统计学意义（,P,<,0.05），UA总有效率2组差异无统计学意义（,P,>,0.05）。治疗组治疗后中医证候积分、FBG、2 h PBG、HbA1C、UA、XOD、hs-CRP、IL-6水平低于对照组（,P,<,0.05），NO水平高于对照组（,P,<,0.05）。,结论,2,与苯溴马隆相比，健脾利湿通络方治疗2型糖尿病合并高尿酸血症安全有效，其疗效机制可能与调控氧化应激和炎症反应有关。

Abstract

Objective,2,To observe the clinical efficacy of Jianpi Lishi Tongluo Decoction in the treatment of type 2 diabetes patients with hyperuricemia.,Methods,2,According to the random number table method，72 patients with type 2 diabetes patients complicated with hyperuricemia， who visited Outpatients and wards of Department of Nephrology and Endocrinology， Beijing Hospital of Traditional Chinese Medicine， affiliated to the Capital Medical University， were selected and divided into treatment group and control group，36 patients in each group. The two groups of patients were treated with standardized diabetes treatment， the treatment group plus Jianpi Lishi Tongluo Decoction，one pachage per day，once in the morning and once in the evening；the control group was given benzbromarone，50 mg/day，once a day. The curative effects of TCM syndromes and uric acid （UA） were compared between the two groups. Fasting blood glucose （FBG）， 2 h PBG， HbA1C， UA， NO， Xanthine oxidase （XOD）， hs-CRP， IL-6 and TCM symptom score in treatment group and control group before and after treatment were observed and compared.,Results,2,The total effective rate of TCM syndromes in the treatment group was higher than that in the control group， there was no statistically significant difference in UA total effective rate（,P,>,0.05）. After treatment，the indexes of FBG， 2 h PBG， HbA1C，UA， XOD， hs-CRP and IL-6 and the TCM syndrome scores in the treatment group were significantly lower than those in the control group （,P,<,0.05），and the content of NO was significantly higher than that in the control group （,P,<,0.05）.,Conclusion,2,Compared with benbromarone group，Jianpi Lishi Tongluo Decoction is safe and effective in the treatment of type 2 diabetes patients with hyperuricemia，and its therapeutic mechanism may be related to oxidative stress and inflammatory response.

关键词

2型糖尿病高尿酸血症健脾利湿通络方氧化应激炎症反应

Keywords

Type 2 diabeteshyperuricemiaJianpi Lishi Tongluo Decoctionoxidative stressinflammatory reaction

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