Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome
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Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome
Beijing Journal of Traditional Chinese MedicineVol. 41, Issue 10, Pages: 1115-1118(2022)
SHI Jie,SHANG Xiu-yang,WANG Li-yun.Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1115-1118.
SHI Jie,SHANG Xiu-yang,WANG Li-yun.Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(10):1115-1118. DOI: 10.16025/j.1674-1307.2022.10.008.
Clinical observation on Qinggan Jiangya Capsules combined with Carvedilol Capsules for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome
Objective,2,To explore the clinical effect and safety of Qinggan Jiangya Capsules combined with Carvedilol Tablets for hypertensive patients with chronic increased heart rate of stagnated heat of liver meridian syndrome.,Methods,2,122 patients with grade 1 and 2 hypertension with resting heart rate >80 beats /min of stagnated heat of liver meridian syndrome admitted to the Cardiovascular Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences from October 2018 to July 2020 were selected and randomly divided into single-drug group and combined-therapy group according to the random number table method. Single-drug group was prescribed Carvedilol 10mg Bid and combined-therapy group was prescribed Carvedilol 10 mg Bid and Qinggan Jiangya Capsules 0.9 g three times a day. Those whose blood pressure didn't reach target control were prescribed Carvedilol 20 mg Bid after two weeks and the whole course was four weeks. The blood pressure, heart rate, TCM syndrome score, curative effect and safety were compared between the two groups before and after treatment.,Results,2,After two and four weeks, not only SBP and DBP, but also rest heart rate in two groups were decreased significantly(,P,<,0.05). After 4 weeks of treatment, SBP in the combined group was lower than that in the single drug group (,P,<,0.05), the blood pressure compliance rate of combined group was higher than that of single drug group (,P,<,0.05). There was no significant difference between the two groups in heart rate compliance rate and the ratio of Carvedilol to 20 mg twice a day (,P,>,0.05).TCM syndrome scores of both groups were significantly decreased after treatment (,P,<,0.05).The TCM syndrome scores of combined-therapy group patients were significantly lower than those of single-drug group patients(,P,<,0.05).The total effective rate of TCM syndrome in combined-therapy group was significantly higher than that in single-drug group and the difference was of statistical significant(,P,<,0.05).There were no adverse reactions in both groups after treatment.,Conclusion,2,Qinggan Jiangya Capsules combined with Carvedilol can improve the blood pressure standard rate of patients with grade 1 and grade 2 hypertension accompanied with chronic heart rate increase, and improve the clinical symptoms of patients. The curative effect is better than that of Carvedilol alone.
关键词
高血压慢性心率增快清肝降压胶囊卡维地洛肝经郁热证
Keywords
Hypertensionchronic increased heart rateQinggan Jiangya CapsulesCarvedilolstagnated heat of liver meridian syndrome