Objective,2,To explore the clinical effect of modified Taohong Siwu Decoction and Wuling Powder combined with hydrochlorothiazide on chronic renal failure（CRF）with blood stasis and water damp syndrome.,Methods,2,60 CRF patients with blood stasis and water dampness syndrome received by Department of Nephrology of Beijing Hospital of Traditional Chinese Medicine Affiliated to the Capital Medical University and Beijing Pinggu District Hospital of Traditional Chinese Medicine from April 2018 to May 2020 were selected and divided into observation group （,n,=30） and control group （,n,=30） . All patients were given the same routine treatment plus orally taking hydrochlorothiazide，and on the basis of treatment in observation group， the control group also combined modified Taohong Siwu Tang plus Wuling Powder treatment， with the treatment course of 2 months. Before and after treatment，TCM syndrome score， 36 Health Survey Synopsis （SF-36）， acute physiological and chronic health condition score II （Apache II） ， renal function index including serum creatinine （CR） ， urea nitrogen （Bun） level and 24h-UTP ， inflammatory index including serum interleukin-6（IL-6），tumor necrosis factor factor （TNF-α）， c-reactive protein （CRP） concentration were measured.,Results,2,The total effective rate of the observation group was 90.00% （27/30） ， which was significantly higher than that of the control group （60.00%，18/30）（,P,<,0.01） . Compared with that before treatment， TCM syndrome scores of both two groups were decreased after treatment （,P,<,0.01）， and the observation group was lower than the control group （,P,<,0.01）. The levels of CR， Bun， IL-6， TNF-α， CRP and 24h-UTP in the two groups after treatment were significantly lower than those before treatment （,P,<,0.05） ， but the levels of above index in the observation group were significantly lower than those in the control Group （,P,<,0.01）. Compared with that of the control group，SF-36 scores were significantly increased （,P,<,0.01） and Apache II scores were significantly decreased （,P,<,0.01） in both groups after treatment， and SF-36 scores were significantly higher （,P,<,0.01） and Apache II scores were significantly lower （,P,<,0.01） in the observation group than in the control group. The side effects were few and mild in both groups.,Conclusion,2,Modified Taohong Siwu Decoction and Wuling Powder combined with hydrochlorothiazide can effectively and safely decrease the expression of serum inflammatory factors in CRF patients with blood stasis and dampness syndrome，and improve their renal function.