Objective,2,To prepare and optimize the animal model of Henoch-Schonlein purpura （HSP） in accordance with the characteristics of Henoch-Schonlein purpura with damp-heat accumulation syndrome of traditional Chinese medicine by comparing three different modeling methods of HSP.,Methods,2,Taking mice as the research object， the HSP animal models of damp-heat type were made by combining three kinds of diseases and syndromes. A damp-heat intrinsic model was established by intragastric administration of fat emulsion +50% alcohol+ traditional Chinese medicine decoction with hot nature （dried ginger/Zanthoxylum bungeanum/Cinnamomum cassia）.Model 1 was intervened by damp-heat syndrome model + HSP skin modeling agent 1 （egg protein+Freund's complete adjuvant）； model 2 was intervened by damp-heat syndrome model +HSP skin modeling agent 2 （egg protein+lipopolysaccharide+aluminum hydroxide gel+Evans blue saline mixture； model 3 was intervened by damp-heat syndrome model+Indian ink+ergot protein solution. The general condition，body mass and skin damage score were recorded， the mouse model was optimized，and the rat was used for verification， and the stability and repeatability of the model among animals with different body types were investigated.,Results,2,Compared with the normal group， there were significant differences in body mass and skin lesion score in model 2（,P,<,0.05）， and the skin lesion score was the highest （7.13±1.46）. The general situation accorded with the model expectation.The results of verification in rat showed that the symptoms of cutaneous purpura were obvious， the score of skin lesions was （7.5±1.51）， the results of skin pathology were typical， and the model was stable and repeatable.,Conclusion,2,Through the construction and evaluation of different modeling methods， the most suitable animal model of HSP damp-heat syndrome was optimized.