Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach

ZHENG Wei-wei; CHEN Bing-bing; HE Fan

doi:10.16025/j.1674-1307.2023.01.028

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Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach

更新时间：2023-06-16

- Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 1, Pages: 111-115(2023)
- 作者机构：
  
  1.温州市中医院消化内科，温州 325000
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.01.028
  CLC：
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郑伟伟，陈冰冰，何璠.针药并用治疗胃食管反流病肝胃郁热证的疗效及作用机制［J］.北京中医药，2023，42（1）：111-115.

ZHENG Wei-wei,CHEN Bing-bing,HE Fan.Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(01):111-115.
郑伟伟，陈冰冰，何璠.针药并用治疗胃食管反流病肝胃郁热证的疗效及作用机制［J］.北京中医药，2023，42（1）：111-115. DOI： 10.16025/j.1674-1307.2023.01.028.

ZHENG Wei-wei,CHEN Bing-bing,HE Fan.Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(01):111-115. DOI： 10.16025/j.1674-1307.2023.01.028.

摘要

目的,2,观察针药并用治疗胃食管反流病（GERD）肝胃郁热证患者的临床疗效及作用机制。,方法,2,将82例GERD肝胃郁热证患者随机分为观察组、对照组各41例。对照组予常规临床治疗方案，观察组加予丹栀逍遥散联合针刺治疗，2组疗程均为8周。比较2组临床疗效、上消化道内镜疗效；比较2组治疗前后中医证候积分，反流性疾病问卷（RDQ）评分，血清胃肠激素［胃泌素（GAS）、胃动素（MTL）、血管活性肠肽（VIP）］、蛋白酶激活受体2（PAR2）以及辣椒素瞬时受体电位阳离子通道亚家族V成员1（TRPV1）水平。,结果,2,与对照组比较，治疗后观察组上消化道内镜炎症总有效率、临床总有效率均高于对照组，RDQ评分、中医证候积分降低，血清GAS、MTL水平升高，血清VIP、PAR2、TRPV1水平降低，差异均有统计学意义（,P,<,0.05）。,结论,2,针药并用辅助西医治疗GERD肝胃郁热证临床疗效较好，其作用机制与调节胃肠激素水平和降低食管高敏感性有关。

Abstract

Objective,2,To observe the therapeutic efficacy of combination of Chinese herbal medicine and acupuncture on gastroesophageal reflux disease （GERD） with syndrome of heat stagnation in liver and stomach.,Methods,2,82 patients were randomly divided into observation group （,n,=41） and control group （,n,=41）. The control group was given routine clinical treatment，and the observation group was given Danzhi Xiaoyao Powder combined with acupuncture on the basis of the control group. The course of treatment of two groups was 8 weeks. The clinical efficacy， upper gastrointestinal endoscopy efficacy， TCM syndrome score， reflux disease questionnaire （RDQ） score， serum gastrointestinal hormone［gastrin （GAS）， motilin （MTL）， vasoactive intestinal peptide （VIP）］， PAR2 and TRPV1 were compared between the two groups.,Results,2,Compared with the control group， the total effective rate of upper gastrointestinal endoscopy and the total clinical effective rate in the observation group were significantly increased， TCM score， RDQ score and serum VIP， PAR2， TRPV1 expression levels in the observation group were significantly decreased and all the differences were statistically significant（,P,<,0.05）.,Conclusion,2,The clinical effect of acupuncture combined with western medicine on GERD with stagnation of heat in liver and stomach is related to the regulation of gastrointestinal hormone level and the reduction of esophageal hypersensitivity.

关键词

胃食管反流病丹栀逍遥散针刺肝胃郁热证

Keywords

Gastroesophageal reflux diseaseDanzhi Xiaoyao Powderacupuncturesyndrome of stagnation of heat in liver and stomach

references

中华医学会消化病学分会.2020年中国胃食管反流病专家共识[J].中华消化杂志,2020,40(10):649-663.

屈坤鹏,成晓舟.我国部分地区胃食管反流病患病率的Meta分析[J].中华胃食管反流病电子杂志,2015,2(1):34-44.

税典奎,罗诗雨,陈峭,等.丹栀逍遥散加减治疗胃食管反流病肝胃郁热证的临床疗效及对患者血清炎性因子的影响[J].河南中医,2019,39(7):1045-1048.

朱淑云,瞿兵,谭远忠.丹栀逍遥散合左金丸加减治疗肝胃郁热型胃食管反流病的疗效以及对胃肠激素水平的影响[J].辽宁中医杂志,2021,48(4):92-95.

吴旭晗,李光耀,邱子殷,等.针灸治疗胃食管反流病有效性的系统评价与Meta分析[J].辽宁中医杂志,2019,46(2):241-247.

刘晓红,孟宪梅,闫伦春.炎症和免疫反应在胃食管反流发病过程中的机制[J].世界最新医学信息文摘,2019,19(55):40-41.

许智超,年媛媛,孟宪梅.TRPV1在胃食管反流病患者发病中的作用机制[J].现代消化及介入诊疗,2021,26(6):697-701.

ARMSTRONG D, BENNETT JR, BLUM AL, et al. The endoscopic assessment of esophagitis: a progress report on observer agreement[J]. Gastroenterology,1996,111(1):85-92.

中华医学会,中华医学会杂志社,中华医学会消化病学分会,等.胃食管反流病基层诊疗指南(2019年)[J].中华全科医师杂志,2019,18(7):635-641.

中华中医药学会脾胃病分会.胃食管反流病中医诊疗专家共识意见(2017)[J].中国中西医结合消化杂志,2017,25(5):321-326.

赵迎盼,廖宇,钟家珮,等.胃食管反流病问卷(GerdQ)与反流性疾病问卷(RDQ)的比较研究[J].胃肠病学和肝病学杂志,2015,24(5):572-574.

郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:364.

LUNDELL LR, DENT J, BENNETT JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification[J]. Gut,1999,45(2):172-180.

郑艺君,史中斐,吕咪,等.基于“三焦气化”论治胃食管反流病经验[J].北京中医药,2022,41(5):524-527.

苏冬梅,刘新平,郑丽,等.培中降逆法治疗反流性食管炎效果观察及机制分析[J].北京中医药,2021,40(12):1381-1384.

郑瑛瑛,陶琳.中医经典方剂治疗胃食管反流病的贝叶斯网状Meta分析[J].北京中医药,2021,40(11):1285-1289.

杨睿,陈炫好,李晋,等.薄荷化学成分及药理活性研究进展[J].天津中医药大学学报,2022,41(1):4-13.

赵悦佳,王彦刚,周平平,等.王彦刚基于核心病机观论治胃食管反流病经验撷英[J].中国医药导报,2022,19(2):152-155.

宋庆增,谢胜,戴文杰,等.督脉经针刺及穴位埋线治疗胃食管反流病的Meta分析[J].中国中医基础医学杂志,2020,26(7):959-962.

高慧,战俊邑,曲夷,等.曹志群教授治疗难治性胃食管反流病的经验[J].中国医药导报,2021,18(35):142-145,166.

王雨玉,张勇.针刺对寒热错杂型胃食管反流病患者临床症状、胃食管动力及生活质量的影响[J].临床医学研究与实践,2021,6(9):133-135.

张伟,奚肇宏,刘梦茹,等.胆胃方对十二指肠食管反流模型大鼠蛋白酶激活受体-2及E-钙黏蛋白的影响[J].中国医药导报,2021,18(32):13-17,197.

唐丽明,宋宁,熊鹰,等.旋覆代赭汤加味治疗肝胃不和型难治性胃食管反流病的临床疗效及对胃肠激素的影响[J].辽宁中医杂志,2020,47(11):109-112.

韩英.胃食管反流病的生物标志物[J].临床荟萃,2017,32(1):5-8,12.

李榕萍,曹雯,张靖娟,等.疏肝健脾和胃方对难治性胃食管反流病患者食管黏膜PAR2及TRPV1蛋白表达的影响[J].福建医药杂志,2017,39(2):80-82.

WINKELSETT L, MALFERTHEINER P, WEX T, et al. Mucosal two-step pathogenesis in gastroesophageal reflux disease: repeated weakly acidic stimulation and activation of protease-activated receptor-2 on mucosal interleukin-8 secretion[J]. Digestion,2018,98(1):19-25.

王勇冲,楼忠泽,徐磊,等.瞬时感受器电位香草酸受体1在胃食管反流病中的研究进展[J].浙江医学,2019,41(11):1232-1236.

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