Objective,2,To explore the effect of diabetes mellitus （DM） complicated with non-alcoholic fatty liver disease （NAFLD） from deficiency， depression， phlegm and blood stagnation.,Methods,2,A total of 95 patients with DM complicated with NAFLD admitted to our hospital from July 2019 to March 2021 were selected and divided into control group （,n,=47） and traditional Chinese medicine group （,n,=48） according to the random number table method.The two groups were given routine intervention such as diet control and exercise program.The control group was given basic treatment，while the traditional Chinese medicine group was treated with Lipi Huatan Quyu Prescription from the perspective of deficiency，depression， phlegm and blood stagnation on this basis of basic treatment.The treatment was given for four months in both groups.The clinical efficacy，liver fat content including FLI and FVF，APN，TNF⁃α，NF⁃κB of two groups were observed；reverse transcription fluorescence quantitative PCR was used to determine serum miR⁃126.The adverse reactions of two groups were recorded.,Results,2,After four months at the end of treatment，the total effective rate of TCM group was higher than that of control group （,P,<,0.05）.The levels of fatty liver index （FLI） and fat volume fraction （FVF） in the two groups after treatment were lower than those before treatment，and those in the TCM group were lower than those in the control group （,P,<,0.05）.The levels of adiponectin （APN） and Mir-126 in the two groups were higher than those before treatment，and those in the TCM group were higher than those in the control group.The levels of tumor necrosis factor-α （TNF-α） and NF-κB in the TCM group were significantly lower than those in the control group （,P,<,0.05）.There were 3 cases of nausea and vomiting and 1 case of rash occurred in the control group，and 1 case of nausea and vomiting in the observation group.The incidence of adverse reactions in the observation group was lower than that in the control group，but the difference was not statistically significant.,Conclusion,2,Treatment of DM combined with non-NAFLD from deficiency，depression，phlegm and blood stagnation based on the intestinal microecology can reduce liver fat accumulation，regulate liver fat content，improve right upper abdominal pain，thirst and polydipsia and other symptoms，and regulate liver fat content，improve the level of intestinal flora and serum related factors.