Clinical observation of Qishen Yiqi Dropping Pills in the treatment of cancer therapeutics-related cardiac dysfunction

ZHANG Xiao-yu; ZHAO Hai-bin

doi:10.16025/j.1674-1307.2023.02.008

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Clinical observation of Qishen Yiqi Dropping Pills in the treatment of cancer therapeutics-related cardiac dysfunction

更新时间：2023-06-16

- Clinical observation of Qishen Yiqi Dropping Pills in the treatment of cancer therapeutics-related cardiac dysfunction
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 2, Pages: 156-161(2023)
- 作者机构：
  
  1.北京中医药大学附属护国寺中医医院针灸科，北京 100034
  2.北京中医药大学东方医院心内科，北京 100078
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.02.008
  CLC：
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张晓羽，赵海滨.芪参益气滴丸治疗抗肿瘤药物相关心功能不全的临床疗效观察［J］.北京中医药，2023，42（2）：156-161.

ZHANG Xiao-yu,ZHAO Hai-bin.Clinical observation of Qishen Yiqi Dropping Pills in the treatment of cancer therapeutics-related cardiac dysfunction[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(02):156-161.
张晓羽，赵海滨.芪参益气滴丸治疗抗肿瘤药物相关心功能不全的临床疗效观察［J］.北京中医药，2023，42（2）：156-161. DOI： 10.16025/j.1674-1307.2023.02.008.

ZHANG Xiao-yu,ZHAO Hai-bin.Clinical observation of Qishen Yiqi Dropping Pills in the treatment of cancer therapeutics-related cardiac dysfunction[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(02):156-161. DOI： 10.16025/j.1674-1307.2023.02.008.

摘要

目的,2,观察芪参益气滴丸治疗恶性肿瘤患者抗肿瘤药物相关心功能不全的临床疗效。,方法,2,选取2017年3月—2021年5月就诊于北京中医药大学附属护国寺中医医院的各种晚期恶性肿瘤合并心功能不全患者150例，采用随机数字表法分为观察组与对照组，各75例。对照组给予常规西药治疗；观察组在此基础上口服芪参益气滴丸，2组均以4周为1个疗程，连续治疗3个疗程。对比2组临床疗效及治疗前后6 min步行距离、血浆脑钠肽（BNP）、心率变异性（HRV）指标［全部窦性心搏RR间期的标准差（SDNN）、相邻RR间期差值的均方根（RMSSD）、RR间期平均值标准差（SDANN）、相邻NN之差>50 ms的个数占总窦性心搏个数的百分比（PNN50）］、心功能指标［左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV），并计算左心室射血分数（LVEF）］、心肌酶学指标［肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）］及血清高敏C-反应蛋白（hs-CRP）、白细胞介素6（IL-6）、用药安全性。,结果,2,观察组治疗后总有效率91.0%，高于对照组的74.2%（,P,<,0.05）；2组治疗后LVEDD、LVESD、CK-MB、LDH及BNP均较治疗前降低（,P,<,0.05），6 min步行距离、SDNN、SDANN、RMSDD、PNN50及LVEF均较治疗前升高（,P,<,0.05），且观察组治疗后6 min步行距离、BNP、HRV指标、心功能指标、血清hs-CRP、IL-6及心肌酶学指标改善情况均优于对照组（,P,<,0.05）。治疗期间2组均未发生药物相关不良反应。,结论,2,芪参益气滴丸配合西药治疗恶性肿瘤患者抗肿瘤药物相关心功能不全疗效优于单纯西药治疗，且安全性较高。

Abstract

Objective,2,To investigate the therapeutic effect of Qishen Yiqi （QSYQ） Dropping Pills on cancer therapeutics-related cardiac dysfunction（CTRCD）.,Methods,2,A total of 150 malignant tumor patients with CTRCD who visited Huguosi Hospital of Chinese Medicine， Beijing University of Chinese Medicine from March 2017 to May 2021 were selected， and according to random number table method，they were divided into control group and observation group，with 75 cases in each one．The control group was given conventional western medicine treatment，and the observation group was given QSYQ Dropping Pills on the basis of the control group．Both groups were treated for one course of 4 weeks，continuously for three courses.Clinical efficacy， 6-minute walking test，BNP， heart rate variability （HRV），including SDNN， RMSSD，SDANN，PNN50， cardiac function indicators including LVEDV， LVESV， myocardial enzymology indexes including CK-MB and LDH， Serum high sensitivity C- reactive protein （CRP）， IL-6 and safety in 2 groups before and after treatment were observed and evaluated.,Results,2,The total effective rate of the treatment group was 91.0%， which was significantly higher than that of the control group，that was 74.2% （,P,<,0.05）. 6-minute walking distance，SDNN，SDANN，RMSDD， PNN50 and LVEF were significantly increased after treatment（,P,<,0.05），The improvement of 6-minute walking distance， BNP， HRV， cardiac function， serum hs-CRP， IL-6 and myocardial enzymology in the observation group were better than those in the control group （,P,<,0.05）. During the treatment，there was no drug-related adverse reaction in both groups（,P,>,0.05）.,Conclusion,2,QSYQ Dropping Pills combined with conventional western medicine has better efficacy in the treatment of CTRCD than only western medicine treatment with high safety.

关键词

芪参益气滴丸抗肿瘤药物相关心功能不全炎性因子

Keywords

Qishen Yiqi Dropping Pillscancer therapeutics-related cardiac dysfunctioninflammatory factor

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