Effect of Chinese herbal medicines for tonifying lung and activating blood circulation on lung function and inflammatory reaction in mice with chronic obstructive pulmonary disease

JING Yue; ZHANG Hong-chun; JIN jin; TANG Shi-huan; CAO Nai-qin; LIAO Qiang; WANG Yue-qi

doi:10.16025/j.1674-1307.2023.03.012

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Effect of Chinese herbal medicines for tonifying lung and activating blood circulation on lung function and inflammatory reaction in mice with chronic obstructive pulmonary disease

更新时间：2023-06-16

- Effect of Chinese herbal medicines for tonifying lung and activating blood circulation on lung function and inflammatory reaction in mice with chronic obstructive pulmonary disease
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 3, Pages: 281-284(2023)
- 作者机构：
  
  1.中国中医科学院望京医院呼吸科，北京 100102
  2.中日友好医院呼吸中心中医肺病科，北京 100029
  3.北京中医药大学东直门医院男科，北京 100027
  4.北京中医医院延庆医院呼吸科，北京 102199
  5.潍坊市中医院呼吸科，潍坊 261000
  6.皖南医学院弋矶山医院中医科，芜湖 241001
  7.中日友好医院中医外科，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.03.012
  CLC：
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敬岳，张洪春，金津，等.补肺活血中药对慢性阻塞性肺疾病小鼠肺功能及炎症反应的影响［J］.北京中医药，2023，42（3）：281-284.

JING Yue,ZHANG Hong-chun,JIN jin,et al.Effect of Chinese herbal medicines for tonifying lung and activating blood circulation on lung function and inflammatory reaction in mice with chronic obstructive pulmonary disease[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(03):281-284.
敬岳，张洪春，金津，等.补肺活血中药对慢性阻塞性肺疾病小鼠肺功能及炎症反应的影响［J］.北京中医药，2023，42（3）：281-284. DOI： 10.16025/j.1674-1307.2023.03.012.

JING Yue,ZHANG Hong-chun,JIN jin,et al.Effect of Chinese herbal medicines for tonifying lung and activating blood circulation on lung function and inflammatory reaction in mice with chronic obstructive pulmonary disease[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(03):281-284. DOI： 10.16025/j.1674-1307.2023.03.012.

摘要

目的,2,观察补肺活血中药对慢性阻塞性肺疾病（COPD）小鼠肺功能、炎症反应的影响。,方法,2,用随机数字表法将60只小鼠分为空白对照组、模型组、补肺活血中药组，每组20只。模型组、补肺活血中药组采用鼻腔滴入LPS加熏香烟的方法建立COPD小鼠动物模型，空白对照组经鼻腔滴入等量生理盐水。空白对照组、模型组于建立模型第1~22天灌服生理盐水0.2 mL/d；补肺活血中药组于建立模型第1~22天灌服补肺活血中药溶液0.82 g/kg，0.2 mL/d。对比各组肺功能指标［呼吸系统阻力（R）、主气道阻力（Rn）、呼吸系统弹力（E）、呼吸系统顺应性（C）］，肺组织病理学变化，肺组织上清液中肿瘤坏死因子α（TNF-α），肺组织中免疫球蛋白A（IgA）、角质细胞生长因子（KGF）基因表达。,结果,2,补肺活血中药组与模型组相比毛发较有光泽，躁动程度减轻，呼吸较均匀。与空白对照组比较，模型组R、Rn高，E、C低，差异有统计学意义（,P,<,0.05）。与模型组比较，补肺活血中药组R、Rn低，E、C高，差异有统计学意义（,P,<,0.05）。补肺活血中药组肺组织病理损伤较模型组减轻。与空白对照组比较，模型组肺组织上清液中TNF-α高，肺组织中IgA、KGF表达高，差异有统计学意义（,P,<,0.05）。与模型对照组比较，补肺活血中药组肺组织上清液中TNF-α低，肺组织中IgA、KGF表达低，差异有统计学意义（,P,<,0.05）。,结论,2,补肺活血中药可改善COPD小鼠肺功能，减轻炎症反应。

Abstract

关键词

慢性阻塞性肺疾病补肺活血肺功能炎症反应免疫球蛋白A肿瘤坏死因子α角质细胞生长因子小鼠

Keywords

references

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