Clinical study of supplementing Qi and Hemostasis Formula in the treatment of upper gastrointestinal bleeding after percutaneous coronary intervention in acute coronary syndrome

XU Yue; LIU Yi-ying; HUANG Dong-lin; LIN Long; WANG Yin-chun; LI Xiao-dong; ZHANG Chen-hao

doi:10.16025/j.1674-1307.2023.05.010

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Clinical study of supplementing Qi and Hemostasis Formula in the treatment of upper gastrointestinal bleeding after percutaneous coronary intervention in acute coronary syndrome

更新时间：2023-06-25

- Clinical study of supplementing Qi and Hemostasis Formula in the treatment of upper gastrointestinal bleeding after percutaneous coronary intervention in acute coronary syndrome
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 5, Pages: 508-512(2023)
- 作者机构：
  
  1.中国中医科学院望京医院急诊科，北京 100102
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.05.010
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徐玥，刘一颖，黄冬林，等.益气止血方治疗急性冠脉综合征患者经皮冠状动脉介入术术后上消化道出血临床研究［J］.北京中医药，2023，42（5）：508-512.

XU Yue,LIU Yi-ying,HUANG Dong-lin,et al.Clinical study of supplementing Qi and Hemostasis Formula in the treatment of upper gastrointestinal bleeding after percutaneous coronary intervention in acute coronary syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(05):508-512.
徐玥，刘一颖，黄冬林，等.益气止血方治疗急性冠脉综合征患者经皮冠状动脉介入术术后上消化道出血临床研究［J］.北京中医药，2023，42（5）：508-512. DOI： 10.16025/j.1674-1307.2023.05.010.

XU Yue,LIU Yi-ying,HUANG Dong-lin,et al.Clinical study of supplementing Qi and Hemostasis Formula in the treatment of upper gastrointestinal bleeding after percutaneous coronary intervention in acute coronary syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(05):508-512. DOI： 10.16025/j.1674-1307.2023.05.010.

摘要

目的,2,观察益气止血方改善急性冠脉综合征患者经皮冠状动脉介入术（PCI）术后消化道出血的临床疗效。,方法,2,选择2020年12月—2022年1月PCI术后发生上消化道出血的患者88例，来自中国中医科学院望京医院、中国中医科学院广安门医院、首都医科大学附属北京朝阳医院，将其用随机数字表法分为观察组和对照组。观察组45例、对照组43例。观察组给予基础治疗+中药益气止血颗粒，对照组给予基础治疗+中药益气止血颗粒模拟剂，疗程均为7 d。对比2组治疗3、7、30 d的出血情况，治疗前后血栓弹力图（TEG）中二磷酸腺苷（ADP）抑制率最大振幅（MA）值及血瘀证评分，治疗期间发生的主要不良心脏事件（MACE）、药物不良事件及肝肾功能。,结果,2,治疗7 d观察组出血率低于对照组（,P,<,0.05），治疗3、30 d观察组出血率与对照组比较差异无统计学意义（,P,>,0.05）。治疗7 d观察组MA值较治疗前下降，对照组较治疗前升高，2组比较差异有统计学意义（,P,<,0.05）。治疗后2组血瘀证评分均呈下降趋势，观察组改善情况显著优于对照组（,P,<,0.05）。观察组发生不稳定性心绞痛1例，恶心、呕吐3例；对照组发生不稳定性心绞痛3例，恶心、呕吐4例。2组肝肾功检查未见异常，无严重药物不良事件发生。2组不良反应发生率比较差异无统计学意义（,P,>,0.05）。,结论,2,益气止血方对于急性冠脉综合征患者PCI术后上消化道出血的治疗，止血效果佳，可显著改善患者血瘀证证候，起到了一定的抗栓作用。

Abstract

Objective,2,To observe the clinical efficacy of supplementing Qi and Hemostasis Formula in the treatment of the PCI postoperative upper gastrointestinal bleeding in acute coronary syndrome.,Methods,2,88 patients with upper gastrointestinal bleeding after PCI from Wangjing Hospital， China Academy of Chinese Medical Sciences， Guang 'anmen Hospital of China Academy of Chinese Medical Sciences and Beijing Chaoyang Hospital affiliated to the Capital Medical University from December 2020 to January 2022 were selected and divided into treatment group of 45 cases and control group of 43 cases according to random number table method. The treatment group was given basic treatment plus Supplementing Qi and Hemostasis Granula，and the control group was given basic treatment plus Supplementing Qi and Hemostasis Granule mock-up. The course of treatment was 7 days. The bleeding rate at 3 days，at 7 days，and within 30 days， the MA value of thrombus elastic graph and the efficacy score of blood stasis evidence in Chinese medicine were observed in both groups.,Results,2,After 7 days of treatment， the bleeding rate in the observation group was lower than that in the control group （,P,<,0.05）. After 7 days of treatment， the MA value in the observation group was decreased compared with that before treatment， while that in the control group increased compared with that before treatment， and the difference between the two groups was statistically significant （,P,<,0.05）.,Conclusion,2,Basic treatment combined with supplementing Qi and Hemostasis Formula can effectively treat upper gastrointestinal bleeding after PCI for acute coronary syndrome， significantly improve the TCM blood stasis syndrome of patients，without affecting the antiplatelet activity of clopidogrel， and so it can play a certain antithrombotic effect.

关键词

益气止血方经皮冠状动脉介入术上消化道出血临床研究

Keywords

Supplementing Qi and Hemostasis Formulapercutaneous coronary interventionupper gastrointestinal hemorrhageclinical research

references

GENEREUX P, giustino G, WITZENBICHLER B, et al. Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention[J]. J Am Col Cardiol，2015,66(9):1036-1045.

FLORIAN K, MATTHIAS W, VIKTOR KK, et al. Real-World Dual Antiplatelet Therapy Following Polymer-Free Sirolimus-Eluting Stent Implantations to Treat Coronary Artery Disease[J]. Cardiovasc Drugs and Ther, 2020,34(3):335-344.

SAITO Y, KOBAYASHI Y. Update on Antithrombotic Therapy after Percutaneous Coronary Intervention[J]. Intern Med, 2020,59(3):311-321.

中华医学会心血管病学分会动脉粥样硬化与冠心病学组,中华医学会心血管病学分会介入心脏病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,等.冠心病双联抗血小板治疗中国专家共识[J].中华心血管病杂志,2021,49(5):432-454.

《中华内科杂志》编辑委员会,《中华医学杂志》编辑委员会,《中华消化杂志》编辑委员会,等.急性非静脉曲张性上消化道出血诊治指南(2018年,杭州)[J].中华内科杂志,2019,58(3):173-180.

郑筱萸.中药新药临床研究指导原则[M].北京：中国医药科技出版社,2002:379-380,383-385.

芦瑞霞,张敏,陈鑫,等.基于文献探讨冠心病介入术前后证候要素演变规律[J].北京中医药,2021,40(11):1262-1266.

李岩,钱真真,翁维良.基于数据挖掘探讨翁维良治疗冠状动脉介入术后再狭窄经验[J].北京中医药,2021,40(11):1212-1214.

张小鸿,徐先祥,汪宁卿.黄芪保护血管内皮细胞作用机制研究进展[J].中国药学杂志,2013,48(18):1526-1530.

米红,李燕舞,王晓燕.黄芪总苷对脾虚大鼠胃黏膜保护机制探讨[J].中药药理与临床,2012,28(05):61-63.

狄亚维,康安,狄留庆,等.三七蒸制前后主要活性成分体内药动学及其抗血小板聚集活性比较研究[J].中草药,2016,47(1):95-100.

冯晓异,赵微,何朋伦,等.三七总皂苷调节iNOS-NO-NF-κB信号通路抑制LPS诱导的RAW246.7细胞炎症研究[J].药物评价研究,2020,43(4):670-675.

国家中医心血管病临床医学研究中心,中国医师协会中西医结合医师分会,中国中西医结合学会活血化瘀专业委员会,等.三七总皂苷制剂临床应用中国专家共识[J].中国中西医结合杂志,2021,41(10):1157-1167.

孙学勤,梁笑,桂双英.冲服水温对三七粉散瘀止血作用的影响[J].安徽农业大学学报,2021,48(5):790-795.

洒晓亮,高之苑,张兰.基于网络药理学探讨太子参、赤芍治疗糖尿病合并冠心病的作用机制[J].中西医结合心脑血管病杂志,2020,18(13):2017-2023.

王玉,杨雪,夏鹏飞,等.大黄化学成分、药理作用研究进展及质量标志物的预测分析[J].中草药,2019,50(19):4821-4837.

刘麟,李京生,鞠海.海螵蛸在制酸止痛应用中不同服药方式验案举隅[J].中国民族民间医药,2018,27(2):82-84.

郭一峰,周文丽,张建鹏,等.海螵蛸多糖对小鼠胃黏膜保护作用的研究[J].第二军医大学学报,2008,29(11):1328-1332.

郑红.海螵蛸对胃粘膜损伤保护及其凝血、止血功效研究[D].福建：福建农林大学,2015.

吕灿利.复方海螵蛸散治疗皮肤溃烂282例疗效观察[J].中医临床研究,2015,7(20):115-116.

CHENG S, ZHANG X, FENG Q, et al. Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway[J]. Life Sci, 2019,15(227):82-93.

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