Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism

TIAN Tian; ZHAO Hui; ZHANG Qiu-yun; CHE Nian-cong

doi:10.16025/j.1674-1307.2023.06.011

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Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism

更新时间：2023-07-18

- Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 6, Pages: 630-635(2023)
- 作者机构：
  
  1.首都医科大学附属北京友谊医院医务处，北京 100050
  2.首都医科大学中医药学院，北京 100069
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.06.011
  CLC：
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田甜，赵晖，张秋云，等.菖蒲郁金汤化裁方对慢加急性肝衰竭大鼠脑损伤所致神经功能障碍的影响及机制［J］.北京中医药，2023，42（6）：630-635.

TIAN Tian,ZHAO Hui,ZHANG Qiu-yun,et al.Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(06):630-635.
田甜，赵晖，张秋云，等.菖蒲郁金汤化裁方对慢加急性肝衰竭大鼠脑损伤所致神经功能障碍的影响及机制［J］.北京中医药，2023，42（6）：630-635. DOI： 10.16025/j.1674-1307.2023.06.011.

TIAN Tian,ZHAO Hui,ZHANG Qiu-yun,et al.Effect of modified Changpu Yujin Decoction on neural dysfunction due to brain injury in rats with acute-on-chronic liver failure and its mechanism[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(06):630-635. DOI： 10.16025/j.1674-1307.2023.06.011.

摘要

目的,2,观察菖蒲郁金汤化裁方对慢加急性肝衰竭（acute-on-chronic liver failure，ACLF）大鼠脑损伤所致精神障碍的影响及机制。,方法,2,30只Wistar大鼠随机分为对照组、模型组和中药组，采用人血清白蛋白免疫诱导大鼠肝纤维化，中药组予以菖蒲郁金汤化裁方灌胃5 d，对照组、模型组均予以0.9%氯化钠注射液灌胃5 d，再予D-氨基半乳糖（D-GalN）/脂多糖（LPS）联合腹腔注射急性攻击，建立ACLF大鼠模型。各组均在急性攻击8 h后麻醉处死。HE染色观察各组肝、脑组织病理变化，电镜观察各组脑组织超微结构变化，Western blotting法检测脑组织抗淀粉样前体蛋白（APP）、突触素（SYN）、生长相关蛋白-43（GAP-43）的表达。,结果,2,与模型组相比，中药组ACLF大鼠神经元及突触超微结构的损伤减轻，脑组织内APP表达降低（,P,<,0.05），SYN和GAP-43表达提高（,P,<,0.05）。,结论,2,通过抑制APP聚集，提高内源性突触相关蛋白表达，保护突触功能并提高其可塑性，可能是菖蒲郁金汤化裁方改善大鼠ACLF后脑损伤所致神经功能障碍的作用机制。

Abstract

关键词

慢加急性肝衰竭肝性脑病突触淀粉前体样蛋白大鼠

Keywords

references

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