Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells

MAO Qi-yuan; ZHANG Ying; LI Dao-rui; ZHENG Qi; ZHAO Zhi-zheng; LIN Hong-sheng; WANG Xue-qian

doi:10.16025/j.1674-1307.2023.07.021

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Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells

更新时间：2023-08-24

- Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 7, Pages: 782-785(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院肿瘤科，北京 100053
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.07.021
  CLC：
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毛启远，张英，李道睿，等.基于肿瘤干细胞诱导多核型髓源抑制性细胞形成介导免疫逃逸探讨中医扶正解毒法防治肿瘤转移的可能机制［J］.北京中医药，2023，42（7）：782-785.

MAO Qi-yuan,ZHANG Ying,LI Dao-rui,et al.Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(07):782-785.
毛启远，张英，李道睿，等.基于肿瘤干细胞诱导多核型髓源抑制性细胞形成介导免疫逃逸探讨中医扶正解毒法防治肿瘤转移的可能机制［J］.北京中医药，2023，42（7）：782-785. DOI： 10.16025/j.1674-1307.2023.07.021.

MAO Qi-yuan,ZHANG Ying,LI Dao-rui,et al.Exploration of possible mechanism of preventing and treating tumor metastasis by strengthening the body resistance and detoxifying in traditional Chinese medicine based on immune escape mediated by the formation of multi-nuclear myeloid inhibitory cells induced by tumor stem cells[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(07):782-785. DOI： 10.16025/j.1674-1307.2023.07.021.

摘要

多核型髓源抑制性细胞（PMN-MDSCs）在肿瘤的免疫逃逸中扮演重要角色，尤其体现在逃逸T淋巴细胞免疫监视方面。肿瘤干细胞具有病理性活化中性粒细胞（PMNs）诱导PMN-MDSCs形成的能力，进而在PMN-MDSCs的帮助下实现免疫逃逸发生转移。中医扶正解毒法对PMN-MDSCs的活化形成及肿瘤干细胞的生物学行为均具有一定的调控作用，这可能为中医药防治肿瘤转移提供了新的依据。基于肿瘤干细胞诱导PMN-MDSCs形成而逃避免疫监视，探讨中医扶正解毒法干预肿瘤转移的可能机制，以期为中医药防治肿瘤转移提供新思路。

Abstract

关键词

肿瘤干细胞多核型髓源抑制性细胞免疫逃逸肿瘤转移中医扶正解毒

Keywords

references

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