Research review on prevention and treatment of bronchiectasis by traditional Chinese medicine

MIAO Qing; JIANG Gan; YUAN Sha-sha; SHI Xia; WANG Bing; FAN Mao-rong

doi:10.16025/j.1674-1307.2023.08.001

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Research review on prevention and treatment of bronchiectasis by traditional Chinese medicine

更新时间：2023-09-18

- Research review on prevention and treatment of bronchiectasis by traditional Chinese medicine
- Beijing Journal of Traditional Chinese Medicine Vol. 42, Issue 8, Pages: 814-818(2023)
- 作者机构：
  
  1.中国中医科学院西苑医院肺病科，北京 100091
  2.北京中医药大学，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2023.08.001
  CLC：
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苗青，姜甘，袁沙沙，等.中医药防治支气管扩张症研究述评［J］.北京中医药，2023，42（8）：814-818.

MIAO Qing,JIANG Gan,YUAN Sha-sha,et al.Research review on prevention and treatment of bronchiectasis by traditional Chinese medicine[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(08):814-818.
苗青，姜甘，袁沙沙，等.中医药防治支气管扩张症研究述评［J］.北京中医药，2023，42（8）：814-818. DOI： 10.16025/j.1674-1307.2023.08.001.

MIAO Qing,JIANG Gan,YUAN Sha-sha,et al.Research review on prevention and treatment of bronchiectasis by traditional Chinese medicine[J]. Beijing Journal of Traditional Chinese Medicine,2023,42(08):814-818. DOI： 10.16025/j.1674-1307.2023.08.001.

摘要

支气管扩张症（简称“支扩”）是我国常见且治疗困难的慢性呼吸道疾病，黏液高分泌、肺功能受损、细菌定植所致感染、反复咯血等问题是支扩发病和进展的关键问题，也是目前治疗的瓶颈。针对恶性“涡旋”机制的多个环节发挥中医药辨证论治的优势显得极为重要。但目前为止，中医药治疗支扩尚缺乏多中心、大样本的临床研究和高质量的循证证据。结合目前研究进展，对于黏液高分泌，应深入挖掘中医化痰药物和方案，以提高支扩患者的治疗水平；对于细菌感染与定植问题，在寻求抗耐药中草药的同时，更重要的是改善患者的免疫状态，减少感染的发生；对伴有气流受限的支扩患者，在使用支气管扩张剂的同时，探讨“肺痈兼喘”的中医方药，以化痰为基础的肃肺平喘法值得进一步研究；对于反复发生的支扩急性加重，应用中医药补肺、健脾、益肾等法，可提高患者的免疫功能。

Abstract

关键词

支气管扩张症“涡旋”假说中医药

Keywords

references

周玉民,王辰,姚婉贞,等.我国7省市城区40岁及以上居民支气管扩张症的患病情况及危险因素调查[J].中华内科杂志,2013,52(5):379-382.

FlUME PA, CHALMERS JD, OLIVIER KN. Advances in bronchiectasis: endotyping, genetics,microbiome,and disease heterogeneity[J].Lancet,2018,392(10150):880-890.

SPAGNOLO P, FABBRI LM, BUSH A. Long-term macrolide treatment for chronic respiratory disease[J]. Eur Respir J,2013,42(1):239-251.

王莉影,桂吟哲,仝润芍.清金化痰汤加减治疗支气管扩张合并肺部感染临床观察[J].中医药临床杂志,2023,35(1):147-151.

谭廉清,周美琴,曾剑澜.清金化痰汤联合氨溴索治疗痰热壅肺型支气管扩张的临床疗效及其安全性[J].临床合理用药杂志,2021,14(7):155-158.

孟林林.清金化痰汤治疗支气管扩张症合并感染（痰热壅肺证）临床疗效观察[D].沈阳:辽宁中医药大学,2021.

袁沙沙,石霞,王冰,等.清补苇茎汤治疗稳定期支气管扩张症伴气道黏液高分泌患者的临床疗效[J].中国实验方剂学杂志,2023,29(1):97-104.

马家驹,陈明,王玉光.小剂量苍麻丸对支气管扩张症稳定期气道黏液高分泌状态的影响[J].中国临床医生杂志,2019,47(6):742-745.

程铄雯.补肺健脾化痰法对非囊性纤维化型支气管扩张症患者气道清除作用的临床观察[D].天津:天津中医药大学,2022.

ANGRILLJ, AGUSTI C, DE CELIS R, et al. Bacterial colonisation in patients with bronchiectasis： microbiological pattern and risk factors[J]. Thorax, 2002,57(1)：15-19.

田欣伦,吴翔,徐凯峰,等. 成人支气管扩张患者的病因及临床特点分析[J].中国呼吸与危重监护杂志,2013,12（06）:576-580.

SERISIER DJ,MARTIN ML,MCGUCKIN MA,et al. Effect of longterm, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis[J].JAMA,2013,309(12):1260.

ALTENBURG J,DE GRAAF C,VAN DER WERF T,et al.Long term Azithromycin treatment: A randomised placebo-controlled trial in non-CF bronchiectasis; results from the BAT trial[J].Eur Respir J,2011,38:1924.

WONG C, JAYARAM L, KARALUS N, et al.Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial[J]. Lancet,2012,380(9842):660-667.

赵世巧,戚世娟,陈丹,等.中药对多重耐药铜绿假单胞菌的抗菌作用研究[J].中国中医急症,2019，28(7):1226-1228，1231.

庞载元,吴贤丽,华毅.4种中药对30株广泛耐药铜绿假单胞菌的抑菌作用[J].中国执业药师,2015,12(2):25-27,45.

黄晓辉,高贵阳,黄志昂.12种中药对20株广泛耐药铜绿假单胞菌的体外抑菌作用研究[J].中国实用医药,2018,13(31):196-198.

丁永娟,谢芬,刘晓媛,等.双黄连注射液对多药耐药铜绿假单胞菌的体外抑制作用[J].华西药学杂志,2014,29(5):547-549.

李亚楠,岑艳灵,孔晋亮,等.黄芩素联合头孢他啶对小鼠腹腔铜绿假单胞菌早期生物被膜感染的体内影响[J].中华医院感染学杂志,2017,27(2):247-250.

樊长征.补中柴前连梅煎减少支气管扩张患者急性加重次数的临床疗效研究[D].北京:中国中医科学院,2016.

樊长征,张文江,任培忠,等.补中柴前连梅煎对支气管扩张症大鼠模型肺气管组织病理学的影响[J].世界中医药,2016,11(11):2370-2374.

樊长征,张文江,张燕萍,等.千金苇茎汤对支气管扩张症中铜绿假单胞菌群体感应系统影响的可行性[J].光明中医,2016,31(2):279-280.

QI Q, WANG W, LI T, et al. Aetiology and clinical characteristics of patients with bronchiectasis in a Chinese Han population: A prospective study[J]. Respirology, 2015,20(6):917-924.

李杰,焦瑞,温林芳,等．支气管扩张症急性加重风险分层评分系统的构建及验证[J].中华结核和呼吸杂志,2016,39(8):598-602.

JAYARAM L, VANDAL AC, CHANG CL, et al.Tiotropium treatment for bronchiectasis: a randomised, placebo-controlled, crossover trial[J]. Eur Respir J, 2022,59(6):2102184.

HAKANSSON KEJ, FJAELLEGAARD K, BROWATAKI A, et al. Inhaled corticosteroid therapy in bronchiectasis is associated with all-cause mortality: a prospective cohort study[J]. Int J Chron Obstruct Pulmon Dis, 2021,16:2119-2127.

钟云青.款冬花散治疗慢性阻塞性肺疾病急性加重期(痰热郁肺证)临床观察[J].中国中医急症,2017,26(1),149-151.

苗青.肃肺平喘方改善支气管扩张症合并气流受限的临床研究ChiCTR2200057025[EB/OL].(2022-02-26)[2023-08-09].https://www.chictr.org.cn /showproj.html? Proj=155633https://www.chictr.org.cn/showproj.html?Proj=155633.

CHALMERS JD, ALIBERTI S, FILONENKO A, et al. Characterization of the "Frequent Exacerbator Phenotype" in Bronchiectasis[J]. Am J Respir Crit Care Med, 2018,197(11):1410-1420.

陈学习,张英杰,李美霞,等.脾虚证与免疫系统关系研究概况与思考[J].中国当代医药,2010,17(34):6-8.

舒晴,喻松仁,白洋,等.脾虚证的免疫学机制研究进展[J].江西中医药大学学报,2018,30(6):116-120.

温庆祥,古颖.四君子汤对脾虚患者免疫功能影响[J].北京中医,2006,25(4):239-240.

季兴祖,刘忠达,李权刘,等.培土生金方对支气管扩张稳定期患者营养状况和免疫功能的影响[J].浙江中医杂志,2020,55(1):26.

周建军,陈建建,吴吉锋,等.补中益气汤治疗支气管扩张稳定期25例[J].江西中医药,2013,44(8):34-35.

李雪,祝勇,郭亚丽,等.升阳益胃汤加减治疗支气管扩张症稳定期脾肺气虚、痰热蕴肺证临床疗效研究[J].辽宁中医杂志,2021,48(6):118-121.

HU M, DING P, MA J, et al. Cost-Effectiveness analysis of the TCM “Yupingfeng Granules” in the treatment of acute exacerbations of COPD based on a randomized clinical trial[J]. Int J Chron Obstruct Pulmon Dis,2022, 17:2369-2379.

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