Objective,2,To observe the clinical effect of meridian flow timing acupoint application in the treatment of senile heart and kidney disharmony type of insomnia.,Methods,2,A total of 60 elderly patients with heart and kidney disharmony type of insomnia who visited the Otpatient Department of Geriatrics and Respiratory Fever in Dongfang Hospital of Beijing University of Chinese Medicine from January 2019 to March 2021 were selected and divided into 2 groups with 30 patients in each group by random envelope method.The control group was given routine treatment and nursing；on the basis of the treatment method of the control group， the observation group was given meridian flow timing acupoint applicatononce d， 4h/time.Both 2 groups were treated with 10 days as one course of treatment for 2 consecutive courses.The effects of the two groups were compared， including Pittsburgh Sleep Quality Index （PSQI） score， TCM syndrome score， Quality of life score （SF-36）and Hamilton Anxiety Scale （HAMA） before and after treatment.,Results,2,The total effective rate was 96.6% in the observation group and 72.4% in the control group， the difference was statistically significant （,P,<,0.05）.After treatment， PSQI scores， TCM syndrome scores and HAMA scores of 2 groups were lower than that before treatment， while SF-36 scores were higher than that before treatment， with statistical significance （,P,<,0.05）.In addition， PSQI scores， TCM syndrome scores and HAMA scores in the observation group were lower than those in the control group （,P,<,0.05）， and SF-36 scores were higher than those in the control group， with statistical significance （,P,<,0.05）.,Conclusion,2,The treatment of senile cardio-renal disharmony with meiridian flow timing acupoint application has remarkable effect， and it can improve sleep quality and quality of life， and relieve anxiety.