Mechanism and effect of acupuncture combined with Tongyou Decoction on recovery of postoperative patients with esophageal cancer of binding of phlegm and blood stasis

HAN Xue; LIU Lei; FAN Zhi-wei

doi:10.16025/j.1674-1307.2024.01.010

您当前的位置：

首页 >

文章列表页 >

Mechanism and effect of acupuncture combined with Tongyou Decoction on recovery of postoperative patients with esophageal cancer of binding of phlegm and blood stasis

更新时间：2024-03-04

- Mechanism and effect of acupuncture combined with Tongyou Decoction on recovery of postoperative patients with esophageal cancer of binding of phlegm and blood stasis
- Beijing Journal of Traditional Chinese Medicine Vol. 43, Issue 1, Pages: 48-52(2024)
- 作者机构：
  
  1.安徽中医药大学附属太和中医院针灸科，太和 236600
  2.安徽中医药大学附属太和中医院外三科，太和 236600
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2024.01.010
  CLC：
- Published：25 January 2024，
  
  Received：20 June 2023，
扫描看全文
韩雪，刘磊，樊志伟.针刺联合通幽汤对痰瘀互结型食管癌术后患者康复的影响及机制［J］.北京中医药，2024，43（1）：48-52.

HAN Xue,LIU Lei,FAN Zhi-wei.Mechanism and effect of acupuncture combined with Tongyou Decoction on recovery of postoperative patients with esophageal cancer of binding of phlegm and blood stasis[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(01):48-52.
韩雪，刘磊，樊志伟.针刺联合通幽汤对痰瘀互结型食管癌术后患者康复的影响及机制［J］.北京中医药，2024，43（1）：48-52. DOI： 10.16025/j.1674-1307.2024.01.010.

HAN Xue,LIU Lei,FAN Zhi-wei.Mechanism and effect of acupuncture combined with Tongyou Decoction on recovery of postoperative patients with esophageal cancer of binding of phlegm and blood stasis[J]. Beijing Journal of Traditional Chinese Medicine,2024,43(01):48-52. DOI： 10.16025/j.1674-1307.2024.01.010.

摘要

目的

观察针刺联合通幽汤对食管癌术后患者康复的影响，并探讨其可能的作用机制。

方法

采用前瞻性研究方法，选取2021年1月—2023年1月太和县中医院收治的痰瘀互结型食管癌患者80例，采用随机数字表法分为对照组和观察组。2组均给予常规手术治疗，对照组术后给予常规对症支持治疗，同时给予抗感染治疗。观察组术后常规治疗方法同对照组，加针刺联合通幽汤治疗。均连续治疗7 d。对比2组首次肛门排气时间、疼痛消失时间、胸管拔除时间、首次进流质饮食时间、引流管拔除时间、住院时间；术前和术后第8天中医证候积分、血清炎症因子（IL-6、TNF-α、CRP）、氧化应激指标（SOD、MDA和GSH-Px）、免疫指标（Th17、Treg细胞比例，Th17/Treg）。

结果

观察组首次肛门排气时间、疼痛消失时间、胸管拔除时间、首次进流质饮食时间、住院时间均较对照组短（

0.05）；2组引流管拔除时间比较差异无统计学意义（

0.05）。术后第8天，2组各项症状中医证候积分均较术前降低（

0.05），且观察组食欲不振、胸胁疼痛评分低于对照组（

0.05）；2组血清IL-6、TNF-α、CRP、MDA、Treg细胞比例均较术后第1天下降（

0.05），2组SOD、GSH-Px、Th17细胞比例、Th17/Treg较术后第1天上升（

0.05），且观察组以上指标变化较对照组明显（

0.05）。

结论

针灸联合通幽汤加减可通过减轻炎症、氧化应激和调节免疫平衡等促进食管癌患者术后快速康复。

Abstract

Objective

To investigate the mechanism and therapeutic effect of acupuncture combined with Tongyou Decoction in promoting postoperative recovery with esophageal cancer.

Objective

Using prospective research methods

a total of 80 patients admitted to the Taihe County Hospital of Traditional Chinese Medicine for esophageal cancer surgery from January 2021 to January 2023 were selected and divided into observation group and control group by random number table method.Both groups were operated.The control group was given conventional symptomatic support treatment after operation and anti-infection treatment at the same time

and the observation group was treated with the same method as the control group after operation and plus acupuncture in combination with Tongyou Decoction. Both groups were treated for 7 days continuously.The first anal exhaust time， the pain resolution time， the chest tube removal time， the first feeding time，drainage tube pull-out time and hospitalization time;scores of TCM syndromes before and 8 days after operation

and the levels of serum inflammatory factors （IL-6， TNF-α， CRP)， oxidative stress indexes (SOD

MDA and GSH-Px)and immune index (Th17

Treg cell ratio

Th17/Treg) were compared before and after treatment.

Results

The observation group showed less time of first anal exhaust， disappearance of pain， removal of thoracic drainage tube， and time of first oral intake of liguid diet and hospitalization compared to the control group （

0.05）. There was no significant difference in the time of pulling out the drainage tube between the two groups (

0.05).On the 8th day after operation

the scores of TCM syndrome in both groups were reduced compared with that before the treatment （

0.05）

and the improvement of loss of appetite and chest pain in the observation group was better than that in the control group （

0.05）.The proportion of serum IL-6

TNF-α

CRP

MDA and Treg cells in the two groups decreased compared with the first day after operation (P

0.05)

while the proportion of SOD

GSH-Px

Th17 cells and Th17/Treg in the two groups increased compared with the first day after operation (

0.05)

and the changes of the above indexes in the observation group were more obvious than those in the control group (

0.05).

Conclusion

Acupuncture combined with modified Tongyou Decoction can promote rapid postoperative recovery in patients with esophageal cancer through its multiple effects of alleviating inflammation， oxidative stress， and regulating immune balance.

关键词

食管癌针刺通幽汤快速康复机制

Keywords

Esophageal canceracupunctureTongyou Decoctionrapid postoperative recoverymechanism

references

THRIFT AP. Global burden and epidemiology of Barrett oesophagus and oesophageal cancer[J]. Nat Rev Gastroenterol Hepatol, 2021,18(6):432-443.

HE S, XU J, LIU X, et al. Advances and challenges in the treatment of esophageal cancer[J]. Acta Pharm Sin B, 2021,11(11):3379-3392.

付佳丽, 仕丽, 杨扬. 浅谈中医药对食管癌术后胃肠功能紊乱的治疗[J]. 中西医结合心血管病电子杂志,2020,8(21):140.

刘磊, 丁昊旻, 于庆生,等. 通幽导滞汤对食管癌患者术后胃肠动力和分泌功能恢复的影响[J]. 广西医学,2020,42(17):2194-2198.

中华人民共和国国家卫生健康委员会医政医管局. 食管癌诊疗指南（2022年版）[J]. 中华消化外科杂志,2022,21(10):1247-1268.

国家药品监督管理局.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002:99-104.

商洪才, 王保和, 张伯礼. 中药新药证候及疗效评价[J]. 中药新药与临床药理,2004,15(5):365-368.

刘泳锌, 李凯, 施心贤,等. 明清时期新安医家诊治噎膈病经验探讨[J]. 中医药临床杂志,2021,33(11):2076-2080.

薛玉玲.电针双侧足三里对腹腔镜结直肠癌根治术后快速康复的临床研究 [D].广州:广州中医药大学,2020.

骆紫燕, 卿德刚, 孙宇,等. 管花肉苁蓉苯乙醇苷的巨噬细胞激活作用及其与当归、黄芪在调节免疫方面的协同作用[J]. 食品工业科技,2020,41(21):311-316.

袁冲, 吴和珍, 刘博,等. 基于网络药理学的半夏抗炎活性成分及作用机制研究[J]. 中华中医药学刊,2020,38(9):150-153,后插17-18.

夏秀丽, 赵树山, 李云,等. 黄芪多糖对小鼠食管癌前病变的影响及机制研究[J]. 陕西中医,2022,43(8):1003-1008.

曹文洁, 黄林生, 刘丽,等. 甘草黄酮醇降尿酸及抑制氧化应激作用及其机制研究[J]. 中国现代应用药学,2023,40(4):448-454.

KUBO N, SAKURAI K, TAMURA T, et al. The duration of systemic inflammatory response syndrome is a reliable indicator of long-term survival after curative esophagectomy for esophageal squamous cell carcinoma[J]. Esophagus, 2021,18(3):548-558.

何芸, 张卫卫, 孔祥云. 血清白细胞介素-6、肿瘤坏死因子-α、活性氧在食管癌术后并发心房颤动患者体内表达水平及检测意义[J]. 陕西医学杂志,2022,51(7):816-819.

谭玉成, 徐建庆. 腹腔镜根治术对胃癌患者肿瘤标志物及氧化应激水平的影响[J]. 陕西医学杂志,2021,50(8):969-972.

YE X, LU Q, YANG A, et al. MiR-206 regulates the Th17/Treg ratio during osteoarthritis[J]. Mol Med, 2021,27(1):64.

KNOCHELMANN HM, DWYER CJ, BAILEY SR, et al. When worlds collide: Th17 and Treg cells in cancer and autoimmunity[J]. Cell Mol Immunol, 2018,15(5):458-469.

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Therapeutic effect and mechanism of combination of acupuncture and Chinese herbal medicine on gastroesophageal reflux disease with syndrome of heat stagnation in liver and stomach

Effect of Jieyu Decoction Combined with Acupuncture in the Treatment of Post-stroke depression:A Randomized Clinical Trial

Assessment about domestic trials of acupuncture for cancer patients’ quality of life in the past five years

The immediate sustained effects of acupuncture at Fengchi（GB20） correlated with visual cortex function:an fMRI study

Improvement ofSchisandrin B for H₂O₂ induced human retinal pigment epithelial cells injury through up-regulation of miR-374a

Related Author

No data

Related Institution

Department of Gastroenterology， Wenzhou Hospital of Traditional Chinese Medicine

Department of Encephalopathy，Shanghai TCM-intergrated Hospital Affiliated to Shanghai University of TCM

Department of Neurology，Shanghai Jiading District Nanxiang Hospital

Emergency department of LongHua Hospital Affiliated to Shanghai University of TCM

Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine

⁰