Objective

2

To observe the clinical efficacy of modified Buyang Huanwu Decoction combined with anticoagulant therapy in the early treatment of acute stage of deep vein thrombosis （DVT） in the lower limbs.

Methods

2

A total of 45 patients with acute lower limb DVT treated at the Vascular Surgery Department of Wangjing Hospital， China Academy of Chinese Medical Sciences， from October 2021 to July 2023 were randomly divided into an observation group （

n

=23） and a control group （

n

=22） using a random number table method. The observation group received oral modified Buyang Huanwu Decoction granules combined

with basic anticoagulant therapy， while the control group received basic anticoagulant therapy alone. The treatment course lasted for 3 months. The Villalta score， bilateral leg circumference differences， coagulation function indicators ［serum D-dimer（D-D）， prothrombin time （PT）， and activated partial thromboplastin time （APTT）］ at baseline （before treatment） and at 1，3， and 6 months after treatment， and lower limb venous recanalization at 6 months were compared between the two groups.

Results

2

After 1 month of treatment， there were no statistically significant differences between the two groups in terms of symptoms， signs， or total Villalta score（

P

>

0.05）. After 3 and 6 months of treatment， the symptoms， signs， and total Villalta scores of both groups had decreased compared with those before treatment， with the observation group showing significantly lower scores than the control group（

P

<

0.05）. At 1，3， and 6 months after treatment， the thigh and calf circumference differences in both groups were reduced compared with those before treatment， with the observation group showing significantly greater reductions than the control group（

P

<

0.05）. After 1，3， and 6 months of treatment， serum D-D levels in both groups were reduced， while APTT and PT were prolonged compared with those before treatment， with the observation group showing significantly better results than the control group（

P

<

0.05）. The complete recanalization rate in the observation group was significantly higher than that in the control group （

χ

2

=1.463，

P

<

0.05）.

Conclusion

2

Modifed Buyang Huanwu Decoction combined with early anticoagulant therapy can significantly improve the clinical symptoms of patients with PTS of lower limb DVT， and its efficacy is superior to anticoagulant therapy alone.