This study uses three prescriptions from different periods written by the Beijing-Tianjin physician GAO Zifen as primary historical materials to explore his medical journey and the related social and historical background from the late Qing Dynasty to the Republic of China. It also details historical facts such as the official medical system and medical research societies in the Beijing-Tianjin region during the late Qing Dynasty， the physician evaluation system under the Beiyang government， and the correspondence-based teaching of traditional Chinese medicine （TCM） during the Republic of China. The study finds that GAO Zifen is not recorded in history， but by examining his surviving prescriptions， it is evident that he was an official doctor in the Southern District of Beijing during the late Qing Dynasty. He later joined the Medical Research Institute to study and engage in clinical teaching. During the Beiyang government， GAO Zifen participated in the Police Department's first medical doctor qualification examination and passed successfully. In the mid-Republic of China， he moved from Beijing to Tianjin to teach at the Correspondence School. Using GAO Zifen's prescriptions as an example， this paper demonstrates the significant historical value of these documents for reference in related research.