Study on the central network mechanism of Shugan Jieyu therapy in the treatment of psychogenic erectile dysfunction with liver Qi stagnation type

MA Ziyang; YU Maobin; REN Feiqiang; ZHANG Peihai

doi:10.16025/j.1674-1307.2025.01.002

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Study on the central network mechanism of Shugan Jieyu therapy in the treatment of psychogenic erectile dysfunction with liver Qi stagnation type

更新时间：2025-01-24

- Study on the central network mechanism of Shugan Jieyu therapy in the treatment of psychogenic erectile dysfunction with liver Qi stagnation type
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 1, Pages: 6-11(2025)
- 作者机构：
  
  1.成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室，成都 610072
  2.重庆市中医院泌尿外科，重庆 400021
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.01.002
  CLC：
- Published：25 January 2025，
  
  Received：13 November 2024，
- 稿件说明：
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MA ZIYANG, YU MAOBIN, REN FEIQIANG, et al. Study on the central network mechanism of Shugan Jieyu therapy in the treatment of psychogenic erectile dysfunction with liver Qi stagnation type. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 6-11.
DOI：

MA ZIYANG, YU MAOBIN, REN FEIQIANG, et al. Study on the central network mechanism of Shugan Jieyu therapy in the treatment of psychogenic erectile dysfunction with liver Qi stagnation type. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 6-11. DOI： 10.16025/j.1674-1307.2025.01.002.

摘要

目的

运用功能性磁共振（fMRI）技术和脑功能网络分析方法，观察疏肝解郁法治疗肝气郁结型心因性勃起功能障碍的临床疗效。

方法

选择2018年10月—2019年9月就诊于成都中医药大学附属医院男科门诊的肝气郁结型心因性ED患者42例，将患者按随机数字表法分为观察组和对照组。观察组予柴胡疏肝散胶囊，对照组予安慰剂胶囊，均5 粒/次，3 次/d，餐后服，4周为1个疗程。对比2组治疗前后平均国际勃起功能问卷-5（IIEF-5）评分、自信心与性关系问卷（SEAR）评分、焦虑自评量表（SAS）与抑郁自评量表（SDS）、勃起功能质量量表（QEQ）评分、平均勃起硬度量表（EHS）、中医证候评分及脑区中枢网络指标［前扣带皮层静息态功能连接（ACC rsFC）、受试者感兴趣区域功能连接（ROI-FC）］。

结果

与治疗前比较，观察组治疗后IIEF-5、SEAR、QEQ评分及EHS分级高（

0.05），SAS、SDS及中医证候评分低（

0.05），且SAS及中医证候评分低于对照组（

0.05）。治疗后，观察组ACC rsFC在以边缘系统为主的脑区较对照组具有相应的增高和减弱变化；观察组右侧前脑岛的ROI-FC在相应脑区较治疗前降低或升高，而对照组ROI-FC未发生显著变化。

结论

以柴胡疏肝散为主方的疏肝解郁法可调节肝气郁结型心因性ED患者脑区的中枢网络功能活动，从而改善阴茎勃起功能。

Abstract

关键词

疏肝解郁法柴胡疏肝散心因性勃起功能障碍磁共振脑中枢网络

Keywords

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